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  1. Seagal

    About to Start a New Protocol

    I would only add the dhea and observe if there is an improvement in symptoms. Imho this is reasonable because your dhea-s tested deficient twice.
  2. Seagal

    Is Fiber Really Essential?

    If “essential” means absolutely required in the same way as some amino acids or certain vitamins, then fiber isn’t considered "essential" in that strict biochemical sense because the body doesn’t require it to perform basic metabolic functions or synthesize essential compounds.
  3. Seagal

    Fat loss diet optimization ++

    Had anyone tried MOTS-C or SLU-PP 332?
  4. Seagal

    Starting TRT Soon

    I think that one can avoid mood swings and other initial side effects if one slowly increases the blood serum T and avoids overshooting. The baseline natural T level then matters because natural production decreases after TRT initialization. E.g. starting at 150 or 450 and aiming at 800 would...
  5. Seagal

    Fainting, High HCT, Low Ferritin — TRT Vet of 15+ Years Needs Help ASAP

    You could donate blood to calm your mind. I would also take an iron supplement as well as the psych meds if they help with the symptoms, and also talk to the psychiatrist. Edit: I'm not sure about the iron supplement after reading @Guided_by_Voices post. Edit2: Reading up on TIBC, saturation. I...
  6. Seagal

    Fainting, High HCT, Low Ferritin — TRT Vet of 15+ Years Needs Help ASAP

    Imho you should compare the current lab report with previous ones in order to identify significant changes. Compare the hematocrit and estrogen values. PCP's reaction is typical... Question is what would be next on the list of possible causes. Your ferritin is further off range than the hct. I...
  7. Seagal

    Why do most say other hormones deplete while on TRT?

    Exactly that has been the problem here. It sounds like it's damn sure that something is broken "this suppression disrupts the entire steroidogenesis pathway[1][3][4]."
  8. Seagal

    Why do most say other hormones deplete while on TRT?

    This theory was popular at excelmale Regarding dhea, pregnenolone (the majority doesn't need to supplement it): Post in thread 'Supraphysiologic testosterone (350 mg weekly)' Supraphysiologic testosterone (350 mg weekly) - Page 3 - Excel Male TRT Forum I believe most issues occur only if men...
  9. Seagal

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    @Cataceous I meant if we had example cases it would be easier to comprehend. We both had a bit discussion about the topic and I think you are right. The details are hard to evaluate. E.g. some TRT clinics prescribe a dht derivative in order to increase free T by lowering shbg. They claim that is...
  10. Seagal

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    @Nelson Vergel and @Cataceous Can you find evidence for both theories/explanations (shbg on TRT etc)?
  11. Seagal

    10 Years on TRT and Only Recent Libido Issues

    Rule out overtraining: 1-2 weeks no weight training.
  12. Seagal

    Re use the individual Cypionate vials or throw away?

    Could keep the remainder in another syringe.
  13. Seagal

    Re use the individual Cypionate vials or throw away?

    Do you mean the 1ml ampoules?
  14. Seagal

    Help w 50mg dosage

    That's correct.
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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