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Advice on next steps - mid-low free T
I do believe that TRT in just about any form is preferable to hypogonadism. However, now that we have an increasing number of choices that are less disruptive of the overall hormonal milieu I would hope these eventually become the new standard of care.- Cataceous
- Post #40
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Advice on next steps - mid-low free T
These are all relatively short and with small N, as they acknowledge: "A large number of clinical trials with relatively small numbers of participants, have been conducted to investigate the effects of testosterone, for generally limited durations of intervention, on various cognitive function...- Cataceous
- Post #31
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Advice on next steps - mid-low free T
As noted, GnRH may play a role in adult neurogenesis. Also in the post I linked to: ”[1] Furthermore: “Multiple lines of evidence indicate that the expression of extrapituitary GnRH receptor is not limited to reproductive tissues. For instance, it has been demonstrated by RT-PCR and Southern...- Cataceous
- Post #23
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Advice on next steps - mid-low free T
Which studies evaluated the rates of dementia? Healthy controls or just untreated hypogonadal subjects? What's needed to answer this question more definitively is a study with large N that has matched eugonadal men as controls. The study needs to last long enough and/or have old enough subjects...- Cataceous
- Post #22
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Adding Anastrozole, how much should I lower dose?
Regardless of whether the testosterone is endogenous or exogenous, the fraction that is aromatized is trivial, and you'd be unable to detect such an increase, subjectively, or even with current lab tests. On the other hand, knocking down a big fraction of estradiol is what can cause significant...- Cataceous
- Post #8
- Forum: Testosterone Basics & Questions
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Advice on next steps - mid-low free T
That's good to know and nice work by Maximus. It sounds like I may be able to add it to the list of short-acting testosterone treatments. I still don't like the use of the term "bioidentical" to differentiate it from products that in the end also yield bioidentical testosterone. "Non-esterified"...- Cataceous
- Post #14
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Adding Anastrozole, how much should I lower dose?
DHT is created from free testosterone. The rate of creation is not expected to change with lower estradiol. This means free DHT should not change. But as with testosterone, if SHBG is driven down by the lower estradiol then total DHT may drop. I should add that I'm ignoring the tiny amount of...- Cataceous
- Post #6
- Forum: Testosterone Basics & Questions
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Adding Anastrozole, how much should I lower dose?
In this situation an aromatase inhibitor should not affect your free testosterone. It could indirectly affect total testosterone by reducing estradiol. Lower estradiol can lead to lower SHBG and therefore lower total testosterone as well. Your dose of testosterone has likely suppressed LH and...- Cataceous
- Post #2
- Forum: Testosterone Basics & Questions
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Advice on next steps - mid-low free T
As I recall, all of the oral forms of testosterone have considerably longer half-lives than the nasal gels. Something like a few hours versus less than an hour. This makes the difference between significant and possibly complete suppression of the HPTA, versus relatively minor suppression. Over...- Cataceous
- Post #4
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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Advice on next steps - mid-low free T
It's less common to have low-T symptoms with that level of free testosterone. I would steer you away from the three treatment options you're considering. They all come with some risk of doing more harm than good given that you're not firmly into hypogonadal territory. If you want to explore...- Cataceous
- Post #2
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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What affects free testosterone under TRT?
I’ve covered this issue in many posts, but I thought it would be helpful to put more information in one thread and expand on the topic. TL;DR: Under TRT, free testosterone is proportional to the dose rate and inversely proportional to the metabolic clearance rate. The liver accounts for most of...- Cataceous
- Thread
- free testosterone liver shbg trt
- Replies: 7
- Forum: Testosterone Basics & Questions
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Limited lab testing by endocrinologists
This is false. The ratio varies and is highly dependent on the SHBG level. For a fixed free testosterone, which occurs at a fixed dose rate, as SHBG goes higher so does total testosterone, and this lowers the ratio of FT to TT. Using measurements of SHBG, albumin and total testosterone you can...- Cataceous
- Post #6
- Forum: Testosterone Basics & Questions
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Modulation of circulating free testosterone fraction by T, DHT and estradiol during TRT
In the case of aromatization you're looking at converting 0.2 to 0.6% of testosterone. Even knocking it out entirely leads to a trivial increase in free testosterone. This myth that a decrease in SHBG leads to an increase in free testosterone may stem from a mistaken idea that total...- Cataceous
- Post #22
- Forum: Testosterone and Men's Health Articles
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Modulation of circulating free testosterone fraction by T, DHT and estradiol during TRT
They are fooling themselves and others. The quality anecdotal evidence I've seen shows that when such steroids are added, free testosterone does not change if the TRT dose remains the same. You can see reduced SHBG, both real and effective, and effects on aromatization. But there is not a...- Cataceous
- Post #20
- Forum: Testosterone and Men's Health Articles
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