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Defy Medical TRT clinic doctor
  1. C

    Less than 50 mg of T per week

    Those are the gold-standard tests. Did you happen to have SHBG measured prior to TRT? If it used to be higher then it's another sign that this testosterone dosing is high for you, as androgens drive down SHBG. However, it's also possible that you are genetically predisposed to low SHBG. Such...
  2. C

    How to decrease SHBG and increase free testosterone

    What do your tests show? Lowering SHBG, either the actual levels, or virtually by tying it up with Proviron, does not affect free testosterone after stabilization, assuming an unchanged TRT dose. The original article should be updated to reflect this. It's covered in detail here...
  3. C

    New Hair Loss Treatment Safer than Finasteride?: Clascoterone 5% Topical Solution

    As I recall, the nightly dose was added to a PG-free Minoxidil Max product, while the morning dose was in ethyl alcohol and cyclomethicone.
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    New Hair Loss Treatment Safer than Finasteride?: Clascoterone 5% Topical Solution

    The dose was 1 mL. 50 mg/mL ~ 5% 25 mg/mL ~ 2.5%
  5. C

    Less than 50 mg of T per week

    Unless you have some other health issue this is suggesting that your dose is still too high for you. Although having total testosterone of 500 ng/dL may not seem excessive, with your daily injections you are probably maintaining this level 24 hours a day. This is an unnatural pattern, as...
  6. C

    New Hair Loss Treatment Safer than Finasteride?: Clascoterone 5% Topical Solution

    I tried clascoterone a few years back and could not tolerate it. At the time I noted a pounding heart and anxiety during two separate trials. The first trial was with 50 mg applied topically twice a day. The second was with half that dose, 25 mg. I asked the Grok AI if excess cortexolone could...
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    TRT Review - Low SHBG, High E2, Crashing Libido

    Any way you look at it the your dosing is excessive—basically double natural production. But regardless, before you head down other rabbit holes consider trying a more sensible initial strategy for treating primary hypogonadism, which I assume is what you have with one or both of the "boys"...
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    Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene

    Here's the complete answer from the AI, for what it's worth: The claim that “your FSH-producing mRNA will decay” during an 8–12-hour overnight break from pulsatile gonadorelin injections is heavily overstated and essentially false in the context of real-world manual pulsatile gonadorelin...
  9. C

    Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene

    @KNDyMan: Your contributions are welcome. A few comments: I am also skeptical of the weekly, high-dose gonadorelin protocols. I have not seen reports on what the subjective results are like. Royal Medical Center did demonstrate high levels of the gonadotropins shortly after the injections...
  10. C

    Lowering trt dose/ increasing frequency of injections question

    I think 65 mg is a reasonable start. Be aware that dose reductions can trigger temporary symptoms of hypogonadism even when levels are adequate. Using proportionality does put total testosterone at weekly troughs in the mid 400s ng/dL with this protocol. As an aside, it is technically more...
  11. C

    Lowering trt dose/ increasing frequency of injections question

    Looking back at your posts I see that you use Testoviron. This includes benzyl benzoate, which does have anti-microbial properties, though it's not as effective as benzyl alcohol. It would not be difficult to purchase some benzyl alcohol and sterile vials to convert the ampules to multi-dose...
  12. C

    GHK-cu and DHT

    I'm not sure about rapid, acute effects. However, I'm now wondering if the ostensible improvements in cognition I experienced are attributable to the GHK-Cu rather than the exogenous GnRH, as I had originally supposed. Or perhaps a synergy. What makes me consider the possibility is that an AI...
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    Lowering trt dose/ increasing frequency of injections question

    With the caveat that these are very crude estimates based on typical absorption rates and should only be used to get a general sense of things: Your trough testosterone of 525 ng/dL with once-weekly injections means we might estimate your weekly peak total testosterone (TT) as 1,300 ng/dL and...
  14. C

    My Father is 70 years old and we just got his labs done. I'd like your advice

    His Vermeulen calculated free testosterone is 9.8 ng/dL. It's considered borderline, but not really into hypogonadal territory. I would not be looking at that first as a cause of his issues, particularly if sexual function is ok. Of course being diabetic harms sexual function on its own. Having...
  15. C

    Second Opinion on Restarting TRT (Primary Hypogandism)

    Was this at 31 days on TRT, or further along? If only a month then suppression would likely progress. Three months would be harder to explain, though it sounds like reduced levels of LH/FSH/GnRH/kisspeptin were still taking a toll on sexual function. I personally have found that restoring some...
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    Second Opinion on Restarting TRT (Primary Hypogandism)

    Unfortunately it seems your doctor did not end up targeting normal LH/FSH as discussed in your previous thread: https://www.excelmale.com/threads/hesitating-on-trt-does-anyone-have-regrets.32140/post-296567 This guy perhaps has a more savvy doctor...
  17. C

    TRT vs Clomiphene: Effect on IGF-1

    The problem is that estrogen measurements have less meaning when one is using a SERM such as enclomiphene or Clomid. SERM's are reducing estrogenic activity without necessarily affecting levels of estradiol. It's also complicated by the fact that SERMs are by definition supposed to be...
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    Peptides for arthritis?

    Another update: Four months ago I administered another series of FGF-18 injections, this time exactly following the standard protocol of three weekly injections of 100 µg. I can't be sure about causality, but not long after that treatment I stopped having intense pain in the knee. This...
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    Kyzatrex vs Maximus Native T

    The improved DHT:T ratio has been below my radar. It's a selling point for me, given my general preference for staying in the confines of normal physiology. There may not be much specific evidence of harm in an elevated ratio, but I'd say the burden of proof should be on those defending the...
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    Kyzatrex vs Maximus Native T

    Let's ask a different question then. Aside from the possible GI link, have any clinically significant differences been found? If not then the whole "native T" thing still seems like marketing obfuscation to me.
  21. C

    Bloodwork results and opinions/advice

    Free testosterone is what's relevant here, not total. His is considered to be healthy and normal for an adult male, and further indicates that the chance of being overtly hypogonadal is quite small. You can argue that statistically it's likely to be somewhat below the average for his age...
  22. C

    Which clinics prescribe propionate?

    @madman has some excellent posts explaining the mechanics of honeymoon periods. When you read men's accounts of these periods you might think TRT is a panacea. The problem is that often the post-honeymoon let-downs are reported in different threads, so you might miss the reality of TRT. The...
  23. C

    Bloodwork results and opinions/advice

    Me: Grok, rewrite this sentence so that even a child can understand it: "Without an age-stratified reference range there's no evidence that your testosterone is particularly low for your age." Grok: We don't have a special chart for this test that shows the normal amounts of testosterone for...
  24. C

    Which clinics prescribe propionate?

    It's challenging to give advice while the story is shifting. The return of morning erections is significant and suggests you should continue with the oral testosterone. You're unlikely to do much better with propionate, although you might enjoy a short-lived honeymoon period. With respect to...
  25. C

    Which clinics prescribe propionate?

    The lab work you posted earlier and the lack of improvements from oral testosterone are suggesting that low testosterone is not your problem. It's not impossible that your elevated E2/T ratio is contributing to issues. If you can lose more weight then that is the preferred way to reduce the...
  26. C

    Bloodwork results and opinions/advice

    Unfortunately you are getting some dubious advice from Vince. Without an age-stratified reference range there's no evidence that your testosterone is particularly low for your age. TRT clinics have an inherent conflict of interest, so just because they might prescribe TRT doesn't mean it's...
  27. C

    Any other Prop blend options?

    Solution: A quick-and-dirty auto-loader. https://www.excelmale.com/threads/need-help-with-t-cypionate-vials-single-vs-multiple-what-do-you-guys-use.27794/post-255297 Yes. I had originally found that getting roughly the same amount of testosterone from each ester led to a diurnal variation in...
  28. C

    High hematocrit

    Not sure what you're looking for. Your doctor had previously prescribed the obvious solution: lowering your dose to a more physiological level. It sounds like you felt some withdrawal symptoms and gave up too quickly. Apparently you also donate blood without telling your doctor. I think you are...
  29. C

    Diminished sexual function after starting TRT

    You're being too charitable. His statement is just ignorance delivered with an air of authority. In the context of the overall hormonal disruption caused by starting TRT, the relatively low dose of hCG is a ways down the list of potential primary causes of sexual dysfunction. @radman: The main...
  30. C

    Any other Prop blend options?

    Unfortunately the DIY approach is likely the only option for getting a propionate blend with a higher fraction of propionate. Discussed in detail here: https://www.excelmale.com/threads/tips-on-how-to-blend-propionate-with-enanthate-or-cypionate.23485/ Obtaining pharma-grade propionate may be...
  31. C

    Primary Hypogonadism: Doctor wants to put me on 25mg of Testosterone enanthate per week

    Though I can't be definitive, I suspect low and steady exogenous testosterone may provide better results in these cases. The idea is to provide a fixed base level of testosterone and then let the HPTA do the fine-tuning. Faster-acting testosterone such as oral or nasal products produce high...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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