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Defy Medical TRT clinic doctor
  1. Seagal

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    HGH makes me tired. Some use it before bedtime for better sleep.
  2. Seagal

    Boswellia the "best" supplement for pain management in knee osteoarthritis

    Funny And probably no placebo effect with horses I took it 3 times per day. I think it reduced inflammation.
  3. Seagal

    Boswellia the "best" supplement for pain management in knee osteoarthritis

    It helped me with knee pain.
  4. Seagal

    Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis

    What supplements have helped you?
  5. Seagal

    Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis

    https://www.cambridge.org/core/journals/psychological-medicine/article/comparative-efficacy-and-tolerability-of-nutraceuticals-for-depressive-disorder-a-systematic-review-and-network-metaanalysis/5799A126D0B5677764562824C452D545 Abstract Background Nutraceuticals have been taken as an...
    • Seagal
    • Thread
    • depression nutraceuticals supplements
    • Replies: 5
    • Forum: Mental Health
  6. Seagal

    HCT and blood donation

    Imo your hct was still good. I do not recommend you do blood donation to reduce your hct. Did you have any symptoms possibly related to hct?
  7. Seagal

    Wild ride! Went from 120mg > 100mg > 80mg > 90mg. T is higher at 90mg 3x a week than 100mg 2x a week

    IMO you have a very good absorption with SC injections. Imo your shbg looked better with 80mg. Could do 3x/w SC to achieve a higher trough level. That would get you closer to your magic number... You should include hct in your labs!
  8. Seagal

    Inject hCG IM for better results?

    https://pmc.ncbi.nlm.nih.gov/articles/PMC6676071/ Figure 1
  9. Seagal

    Inject hCG IM for better results?

    So true. Had here discussions about androgel T level dropping to the end of the day. One member here kept on posting studies that show that levels are stable. Finally evidence accumulated and serum tests showed differently. It wasn't only me... That 10-20% 'outliers' often get 'averaged out' in...
  10. Seagal

    TRT in Canada if borderline Testosterone and Prolactin?

    Estrogen does increase prolactin and elevated estrogen can move balance towards less dopamine. @LookingForAnswers
  11. Seagal

    7.5mgs daily labs

    Could be bit higher or bit lower. If you want to know for sure you would need to take blood several times the day to get an estimate of the daily variation. It might differ slightly from day to day. It really doesn't matter. I'm afraid the question was initially asked with malign intend stemming...
  12. Seagal

    7.5mgs daily labs

    I noticed the timing too and thought about it. In my experience the SQ gives a delayed and flattened response. No idea when there would be a minor peak during the 24h window. Maybe we can agree that next time he measures before the injection. I really don't expect any relevant difference. Don't...
  13. Seagal

    7.5mgs daily labs

    It's SQ and daily. Would be nice to have a 24h graph of T level in general but that's not the purpose here.
  14. Seagal

    TRT in Canada if borderline Testosterone and Prolactin?

    You are right about your prolactin being only slightly above range. Also opinions vary about T optimization. Imo the information about your nutrition might be crucial. I recommend you try cyclic keto including 1-2 days per week where you eat 'normal' reloading on carbs. Did you get a test for...
  15. Seagal

    7.5mgs daily labs

    Good starting dose and good starting level achieved, good absorption with SQ. You could wait few more weeks and let things settle, you might start feeling better on that dose/level. Imo an increase of about 10mg per week would be a good choice.
  16. Seagal

    Thyroid Labs for Dixiewrecked

    No, never got the RT3 from my GP. I meant your mental symptoms. It felt like the benefits of the morning 6ug T3 phased out or I got used to it. Maybe I will try again. Partial cold shower in the morning after my normal shower has had positive effects. Eating a small breakfast instead of only...
  17. Seagal

    Updated Labs - Help Please

    If that's the goal, I would need about 250mg TU per week. One SQ injection at glute region. No problem. Oral or topical requires even much more T and money. That's not the point here, right? I thought only the sudden lower E2 is the problem. Now that I understand your intention, it makes sense...
  18. Seagal

    Updated Labs - Help Please

    Could just inject more SQ if it's not enough. I don't think that SQ is generally wrong or inferior.
  19. Seagal

    Updated Labs - Help Please

    It's strange that your e2 is suddenly at the low end. IMO it's not necessary to inject ed when injecting SQ. I would go with eod SQ. What's going on with your wbcc and bilirubin?
  20. Seagal

    Thyroid Labs for Dixiewrecked

    I felt like elevated e2 had these effects on me. I know, not the whole E2 discussion again. Just wanted to mention it to you. Adding a bit T3 in the morning helped for a while. I think the whole hype that TSH should be below 2.0 is nonsense.
  21. Seagal

    TRT in Canada if borderline Testosterone and Prolactin?

    High prolactin can cause your symptoms! Your testosterone is not borderline. Do you take any medications?
  22. Seagal

    New to TRT. Received first labs. Concerned and need help.

    Most interesting starting around 19 min Starting dose depends on baseline T level, age, health, shbg. Just another voice. Hope that distracts you both from your neverending debate ;) @Phil Goodman @Cataceous
  23. Seagal

    Pregnenolone pathways and outcomes

    IIRC oral converts through digestive pathway (much more) to preg sulfate which transports preg to the brain and servers as storage molecule. The dose matters, too much oral preg makes me tired. Which aspects of your life are improved by topical pregnenolone? What doses did you try (oral...
  24. Seagal

    Testosterone Cypionate vs Testosterone Undecanoate

    I use TU once per week. I suggest you first try once per week TC to achieve a more stable T level.
  25. Seagal

    Giving up on TRT after 5 years

    Thank you for sharing your experience. Seems like you got all the possible side effects of (super physiological testosterone) TRT.
  26. Seagal

    Building a TRT protocol around hCG

    DeepSeek voodoo **Important Nuances:** * **Lower Brain Concentration than Testosterone:** Despite crossing the BBB, DHT generally achieves lower concentrations in the brain *from the bloodstream* compared to testosterone. This is partly because: * **High Plasma Protein Binding:**...
  27. Seagal

    Building a TRT protocol around hCG

    How do we know that (for sure)? It will do something. Fingers crossed
  28. Seagal

    Building a TRT protocol around hCG

    Have to add that I'm skeptical about the prediction graphs. It looked appealing to me because of my recent speculation about E2 clearance and the role of it in the regulation of LH peaks. E2 regulated to be in physiological range and T being secondary. E2 'control' and/or addition of DHT is...
  29. Seagal

    Building a TRT protocol around hCG

    Estradiol non-linearity DHT up and E2 down seems a direction to explore. What you pointed out, your DHT to E2 ratio. No new information to you however nice plots https://pmc.ncbi.nlm.nih.gov/articles/PMC9016457/
  30. Seagal

    Building a TRT protocol around hCG

    Great experiment. Thank you for sharing!
  31. Seagal

    Building a TRT protocol around hCG

    ChatGPT imitates MDs With deepseek deep thinking activated I can follow the internal reasoning and ask critical follow-up questions. After few follow-up questions the output seems reasonable to me whether it's then accurate and unbiased is another problem.
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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