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Why do most say other hormones deplete while on TRT?
While it's unequivocal that exogenous testosterone can affect a large number of other hormones/precursors by disrupting various feedback loops, the argument would be that it's statistical in nature, with substantial variation between individuals. It's more clear-cut with hormones such as LH and...- Cataceous
- Post #2
- Forum: Testosterone Basics & Questions
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Syringe Holder/Loader
Another simple option, a piece of stiff wire bent to hold the vial and hang it from something. A wood chip, syringe cap, etc. holds the plunger out:- Cataceous
- Post #9
- Forum: Testosterone Basics & Questions
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What it the purpose of Sex Hormone Binding Globulin (SHBG) ?
In fact I recall at least two or three examples posted over the years, though I'd be hard pressed to find them. I believe @Gman86 was one of them. The idea is that a guy on TRT maintains that dosing while adding some other androgenic steroid. The outcome is typically a double whammy for SHBG...- Cataceous
- Post #26
- Forum: Testosterone Basics & Questions
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What it the purpose of Sex Hormone Binding Globulin (SHBG) ?
Yes, and the AI misinterpreted them, as shown in detail above. That's not what's being said. In the specific case of free testosterone and SHBG the same rules do apply, because selecting the dose rate under TRT is analogous to the body's direct regulation of free testosterone by altering its...- Cataceous
- Post #24
- Forum: Testosterone Basics & Questions
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What it the purpose of Sex Hormone Binding Globulin (SHBG) ?
It also applies to TRT. Grok 3 again: Conclusion Given that testosterone metabolism follows first-order kinetics with respect to free testosterone, and at steady state the dose rate equals the elimination rate, the free testosterone level is indeed directly proportional to the dose rate. The...- Cataceous
- Post #19
- Forum: Testosterone Basics & Questions
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What it the purpose of Sex Hormone Binding Globulin (SHBG) ?
Battle of the AIs. This is Grok 3: I agree with your assessment that in normal physiology, it’s a misconception to think that the level of Sex Hormone-Binding Globulin (SHBG) directly affects the amount of free testosterone. Here’s why: Understanding SHBG and Testosterone SHBG is a protein...- Cataceous
- Post #17
- Forum: Testosterone Basics & Questions
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Re use the individual Cypionate vials or throw away?
If these are glass ampules that you break open then you need to transfer the contents to a normal stoppered vial to preserve sterility. I would also verify that a preservative is included in the formulation and ideally use a filter needle to remove possible glass fragments.- Cataceous
- Post #7
- Forum: Testosterone Basics & Questions
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Re use the individual Cypionate vials or throw away?
I and many of the guys here have been known to use such vials for many months. While there's no guarantee something bad won't happen, the odds of that are clearly small. From the standpoint of microbial contamination, you can be less concerned if you're injecting subcutaneously because a shallow...- Cataceous
- Post #2
- Forum: Testosterone Basics & Questions
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Starting TRT Soon
Allow me to offer an even more conservative perspective. That 100 mg per week of testosterone cypionate would already be giving you more testosterone than most men ever make naturally. The average testosterone production for healthy young men is equivalent to around 60-70 mg of testosterone...- Cataceous
- Post #8
- Forum: Testosterone Basics & Questions
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Ran out of wife's testosterone-can she use mine?
Short answer: It's fine. Long answer: Assuming you mean she takes 0.07 mL TC @ 50 mg/mL, this is 3.5 mg TC. So as you say, taking a quarter of the volume of your 200 mg/mL TC—0.0175 mL—does yield the same 3.5 mg dose of TC. I wouldn't hesitate to do it. Your only issue is the precision of the...- Cataceous
- Post #2
- Forum: Testosterone Basics & Questions
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Dosage recommendations when switching esters.
In my estimation, if you preserve daily peak testosterone then the transition should be relatively smooth. Using my own measurements I can give you a rough estimate of how much to lower the dose. Daily cypionate is assumed to give pretty flat serum testosterone. For me, at least, daily...- Cataceous
- Post #3
- Forum: Testosterone Basics & Questions
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Compounding Pharmacies and Test Raws and Tariffs
I wouldn't panic. Particularly for compounded testosterone, the price of the raw material has to be a fairly small fraction of the end product price. Only somewhat more so for UGL. For example, one AI puts the bulk price per kilogram of testosterone cypionate at $500-$2,000. Via Defy Medical...- Cataceous
- Post #3
- Forum: Compounding Pharmacy Product Reviews
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current protocol for preserving testicular function with TRT
HCG monotherapy is a reasonable choice given the concerns about fertility. Anecdotes tend to disfavor it with respect to subjective results. This may be due to the potential for excess aromatization. But some guys seem happy with it. Let me throw in Dr. Saya's fertility ranking to give you an...- Cataceous
- Post #6
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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current protocol for preserving testicular function with TRT
Usually there's a minimum of 250 IU hCG twice a week up to a maximum of maybe 500 IU three times a week. Around 750-1,000 IU per week in divided doses is typical.- Cataceous
- Post #4
- Forum: hCG, Clomid & Others for Fertility, PCT or Low T
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