Search results

Defy Medical TRT clinic doctor
  1. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    I don't know the practical limitations on particle size for testosterone suspension. Maybe there's a cost-benefit tradeoff? In addition, the interest in very fast-acting testosterone is more recent and still limited. Bear in mind that testosterone basically does not dissolve in water. However...
  2. C

    Blood panel, how's mine look?

    Your instincts are good with respect to dose frequency. With once-weekly doses of testosterone cypionate it's common to have peak levels that are two to three times trough levels. This is decidedly unnatural. Assuming your lab work is at trough then you are likely going from very high to mid-low...
  3. C

    How BMI Influences Testosterone Boosts: Up-Titration Results for Oral Testosterone Undecanoate

    Apparently this study did not track free testosterone, which makes the results considerably less useful. Higher BMI is expected to correlate with lower SHBG [R], which leads to lower total testosterone for the same level of free testosterone. Therefore these cohorts with different BMIs could...
  4. C

    Clomid for Testicular Shrinkage ?

    The most common cause of thyrotoxicosis in pregnancy is gestational transient thyrotoxicosis (GTT), which occurs from the stimulatory action of human chorionic gonadotropin (HCG) on the TSH receptor. https://pmc.ncbi.nlm.nih.gov/articles/PMC4166486/ Interesting. There's always something new...
  5. C

    The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)

    I can't say with certainty, but I think it's associated with improved mood and motivation. There are no side effects that I'm aware of.
  6. C

    The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)

    I do take it orally, on waking with an empty stomach.
  7. C

    The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)

    Yes, I've been taking 2.5 mg/day consistently.
  8. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    I've taken the first one, which is to investigate where the missing testosterone went. It appears likely that the filtering action of a small needle is part of the problem, along with wastage via particle deposition on the vials. The empty vial that had contained 1 mL of the TS and 1 mL of...
  9. C

    Testosterone no ester

    If you're including testosterone suspension in this then yes, I am using it as a form of TRT. As documented here, I recently tried measuring the response over time. My protocol has involved injecting a nominal 1.5 mg three times a day. But based on lab work I'm beginning to suspect the actual...
  10. C

    Building a TRT protocol around hCG

    This is very much in line with my thinking, particularly the part about a longer HTPA shutdown being more problematic. In my case the addition of hCG was an improvement, but it never led to consistent libido and/or sexual function, and things still went downhill over the years. Dropping the hCG...
  11. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    Lately I’ve been insinuating that some testosterone suspension products may qualify as fast-acting, and therefore be in the same league as testosterone nasal gels and buccal troches. The “fast-acting” quality is important if the goal is to retain HPTA function in the presence of exogenous...
  12. C

    Advice on next steps - mid-low free T

    I do believe that TRT in just about any form is preferable to hypogonadism. However, now that we have an increasing number of choices that are less disruptive of the overall hormonal milieu I would hope these eventually become the new standard of care.
  13. C

    Advice on next steps - mid-low free T

    These are all relatively short and with small N, as they acknowledge: "A large number of clinical trials with relatively small numbers of participants, have been conducted to investigate the effects of testosterone, for generally limited durations of intervention, on various cognitive function...
  14. C

    Advice on next steps - mid-low free T

    As noted, GnRH may play a role in adult neurogenesis. Also in the post I linked to: ”[1] Furthermore: “Multiple lines of evidence indicate that the expression of extrapituitary GnRH receptor is not limited to reproductive tissues. For instance, it has been demonstrated by RT-PCR and Southern...
  15. C

    Advice on next steps - mid-low free T

    Which studies evaluated the rates of dementia? Healthy controls or just untreated hypogonadal subjects? What's needed to answer this question more definitively is a study with large N that has matched eugonadal men as controls. The study needs to last long enough and/or have old enough subjects...
  16. C

    Adding Anastrozole, how much should I lower dose?

    Regardless of whether the testosterone is endogenous or exogenous, the fraction that is aromatized is trivial, and you'd be unable to detect such an increase, subjectively, or even with current lab tests. On the other hand, knocking down a big fraction of estradiol is what can cause significant...
  17. C

    Advice on next steps - mid-low free T

    That's good to know and nice work by Maximus. It sounds like I may be able to add it to the list of short-acting testosterone treatments. I still don't like the use of the term "bioidentical" to differentiate it from products that in the end also yield bioidentical testosterone. "Non-esterified"...
  18. C

    Adding Anastrozole, how much should I lower dose?

    DHT is created from free testosterone. The rate of creation is not expected to change with lower estradiol. This means free DHT should not change. But as with testosterone, if SHBG is driven down by the lower estradiol then total DHT may drop. I should add that I'm ignoring the tiny amount of...
  19. C

    Adding Anastrozole, how much should I lower dose?

    In this situation an aromatase inhibitor should not affect your free testosterone. It could indirectly affect total testosterone by reducing estradiol. Lower estradiol can lead to lower SHBG and therefore lower total testosterone as well. Your dose of testosterone has likely suppressed LH and...
  20. C

    Advice on next steps - mid-low free T

    As I recall, all of the oral forms of testosterone have considerably longer half-lives than the nasal gels. Something like a few hours versus less than an hour. This makes the difference between significant and possibly complete suppression of the HPTA, versus relatively minor suppression. Over...
  21. C

    Advice on next steps - mid-low free T

    It's less common to have low-T symptoms with that level of free testosterone. I would steer you away from the three treatment options you're considering. They all come with some risk of doing more harm than good given that you're not firmly into hypogonadal territory. If you want to explore...
  22. C

    What affects free testosterone under TRT?

    I’ve covered this issue in many posts, but I thought it would be helpful to put more information in one thread and expand on the topic. TL;DR: Under TRT, free testosterone is proportional to the dose rate and inversely proportional to the metabolic clearance rate. The liver accounts for most of...
  23. C

    Limited lab testing by endocrinologists

    This is false. The ratio varies and is highly dependent on the SHBG level. For a fixed free testosterone, which occurs at a fixed dose rate, as SHBG goes higher so does total testosterone, and this lowers the ratio of FT to TT. Using measurements of SHBG, albumin and total testosterone you can...
  24. C

    Modulation of circulating free testosterone fraction by T, DHT and estradiol during TRT

    In the case of aromatization you're looking at converting 0.2 to 0.6% of testosterone. Even knocking it out entirely leads to a trivial increase in free testosterone. This myth that a decrease in SHBG leads to an increase in free testosterone may stem from a mistaken idea that total...
  25. C

    Modulation of circulating free testosterone fraction by T, DHT and estradiol during TRT

    They are fooling themselves and others. The quality anecdotal evidence I've seen shows that when such steroids are added, free testosterone does not change if the TRT dose remains the same. You can see reduced SHBG, both real and effective, and effects on aromatization. But there is not a...
  26. C

    Modulation of circulating free testosterone fraction by T, DHT and estradiol during TRT

    This highlights the confusion about whether total or free testosterone is the dependent variable. I've been arguing for years that total testosterone is the dependent variable, determined by free testosterone and the binding protein levels and other hormone levels. o The new data show that this...
  27. C

    Modulation of circulating free testosterone fraction by T, DHT and estradiol during TRT

    I believe they are making this more complicated than necessary, and potentially reversing causes and effects. Under TRT the dose rate and metabolic clearance rate directly and proportionally determine free testosterone. In turn, total testosterone is driven primarily by free testosterone, SHBG...
  28. C

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    We went through it again just last month, in this thread a few posts back. Being on TRT is not relevant. Free testosterone is driven by the rate of testosterone entering the system: https://www.excelmale.com/threads/what-it-the-purpose-of-sex-hormone-binding-globulin-shbg.24916/post-297524
  29. C

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    We've been discussing this for years now. SHBG has little influence on free testosterone. The shift to lower SHBG under TRT does not change free testosterone at steady state. Free testosterone is determined by the dose rate and the metabolic clearance rate constant. The same applies when SHBG...
  30. C

    9 years on Gel - Switch to Injection - Effect on HCT?

    It depends on your dose. The thing about injections is that it's much too easy to overdose, and most men do. For example, the common starting dose of 100 mg of testosterone cypionate per week is well above typical healthy natural production, which is equivalent to more like 50-70 mg. Regarding...
  31. C

    Are the creams less likely to raise hematocrit?

    The problem with HCT is still going to be primarily a function of dose. If you absorb a similar amount of testosterone via cream and serum levels are fairly steady then the results probably won't be much different. There is some complexity with respect to the pattern in serum testosterone. Based...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

Beyond Testosterone Podcast

Share this page

Sponsors

bodybuilder test discounted labs
buy enclomiphene
Discounted Labs
Testosterone Doctor Near Me
Register on ExcelMale.com
Trimix HCG Offer Excelmale
BUY HCG CIALIS
Beyond Testosterone Book by Nelson Vergel
Back
Top