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  1. J

    Metformin as an Aromatase Inhibitor?

    The use of HGH causes glycemic issues to occur in certain individuals, particularly if one were taking it at dosages well above recommended for anti aging, so I was taking it for both reasons mentioned.
  2. J

    Metformin as an Aromatase Inhibitor?

    To add to your statement, I have a corollary: I am running HGH as well on top of testosterone. I use the Metformin to keep glucose issues associated with HGH in check and to keep my estradiol in range. The deficits associated with Metformin arguably won't apply to someone running HGH given...
  3. J

    Metformin as an Aromatase Inhibitor?

    I get the same symptoms of fatigue when running Metformin. I find that taking my dose before bed eliminates the problem entirely.
  4. J

    Metformin as an Aromatase Inhibitor?

    Yes, but only in natural men who are not on TRT, and it does so via the same mechanism as the manner by which it reduces hyperandrogenic symptoms in PCOS patients (hyperinsulinemia causes a spike in FSH which causes androgen producing cells to increase their production). In cases where a man's...
  5. J

    Metformin as an Aromatase Inhibitor?

    Well, yes. Hyperinsulinemia is a factor in excessive aromatization. The production of insulin stimulates aromatase. Metformin reduces insulin, thereby curbing the activity of aromatase via the aforementioned downstream mechanism. Do note that I am not advocating the use of Metformin as an...
  6. J

    Metformin as an Aromatase Inhibitor?

    Getting right to the point, study upon study has shown that Metformin appears to be an efficacious aromatase inhibitor. For those of you taking it with TRT, have you noticed any low E2 related symptoms associated with its use? On a side note, this might just solve the myriad of E2 related...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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