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  1. Seagal

    Testosterone Cypionate vs Testosterone Undecanoate

    I use TU once per week. I suggest you first try once per week TC to achieve a more stable T level.
  2. Seagal

    Giving up on TRT after 5 years

    Thank you for sharing your experience. Seems like you got all the possible side effects of (super physiological testosterone) TRT.
  3. Seagal

    Building a TRT protocol around hCG

    DeepSeek voodoo **Important Nuances:** * **Lower Brain Concentration than Testosterone:** Despite crossing the BBB, DHT generally achieves lower concentrations in the brain *from the bloodstream* compared to testosterone. This is partly because: * **High Plasma Protein Binding:**...
  4. Seagal

    Building a TRT protocol around hCG

    How do we know that (for sure)? It will do something. Fingers crossed
  5. Seagal

    Building a TRT protocol around hCG

    Have to add that I'm skeptical about the prediction graphs. It looked appealing to me because of my recent speculation about E2 clearance and the role of it in the regulation of LH peaks. E2 regulated to be in physiological range and T being secondary. E2 'control' and/or addition of DHT is...
  6. Seagal

    Building a TRT protocol around hCG

    Estradiol non-linearity DHT up and E2 down seems a direction to explore. What you pointed out, your DHT to E2 ratio. No new information to you however nice plots https://pmc.ncbi.nlm.nih.gov/articles/PMC9016457/
  7. Seagal

    Building a TRT protocol around hCG

    Great experiment. Thank you for sharing!
  8. Seagal

    Building a TRT protocol around hCG

    ChatGPT imitates MDs With deepseek deep thinking activated I can follow the internal reasoning and ask critical follow-up questions. After few follow-up questions the output seems reasonable to me whether it's then accurate and unbiased is another problem.
  9. Seagal

    TRT+ other medications

    I remember this. Sparse data above 800. After what time? Thanks for also posting the scatterplot. The origin is not zero, could draw the blue line closer to the red. However it nicely visualizes what is meant by saturation in this context. I measured after about 10 months. I'm the blue . Maybe...
  10. Seagal

    TRT+ other medications

    I thought you wanted to try the HCG-base protocol You are right, 500-1000IU per week seems standard on top of TRT I understand.
  11. Seagal

    TRT+ other medications

    Your protocol had no chance of success. Two options? Option 1) Carefully sprinkle T on top of hcg. Option 2) Carefully sprinkle hcg on top of T. Add: Considering the impact of E2 on your libido and the significant physique benefits you experienced on TRT.... ,ust a peer-reviewer thought: how...
  12. Seagal

    TRT+ other medications

    I just found it interesting and wanted to share it, and luckily you guys can think for yourself. Thank you for the peer review. Appreciated!
  13. Seagal

    TRT+ other medications

    While writing the first post I recalled your story of im vs sq. Maybe it's less the aromatization in your fat tissue and more the higher variation of your T level that balance T influx vs W2 clearance. And yes, thanks for clarifying my super brief speculation. TRT without hcg i.e. no...
  14. Seagal

    TRT+ other medications

    I think this aromatase saturation happens far outside the physiological range. For me on TU, double dosis resulted in double max reference range levels of fT and fE2 (250mg vs 125mg). We humans trying to make sense of biological systems. Many traps because they are not by design...
  15. Seagal

    TRT+ other medications

    Deep seek: Even when hCG is used to achieve *physiological* testosterone levels, there is **still a significant risk of excessive estrogen (estradiol) conversion** in men. Here’s why and how it happens: --- ### **The Science: Why Estrogen Rises with hCG** 1. **Aromatization Overdrive**: -...
  16. Seagal

    TRT+ other medications

    DeepSeek * **United States:** Estimates suggest **4-5 million men** are prescribed testosterone therapy in the US. Usage has increased significantly over the last decade. * **Worldwide:** Global figures are harder to pin down precisely due to varying regulations and...
  17. Seagal

    TRT+ other medications

    I laid out the ground work and was waiting for such comments.
  18. Seagal

    TRT+ other medications

    Oh, nothing personal! Was wondering, if all men on trt would take hcg, how many pregnant women would we need to harvest for hcg per year. The whole pee aspect makes me feel uncomfortable. Luckily we have India I'm hoping for an esterified version of lh
  19. Seagal

    TRT+ other medications

    Happy hunting my friend
  20. Seagal

    TRT+ other medications

    According to DeepSeek you need about one pregnant woman per year to harvest your hcg. 80L of trimester urine for 52k IU ### The Standard Yield - **1 liter (L) of first-trimester pregnant urine** → Yields **≈1 mg of purified hCG** after industrial processing. - Since **1 mg hCG ≈ 650 IU**, this...
  21. Seagal

    TRT+ other medications

    If I knew what my normal healthy level was before it crushed to about 150, that would be the reference value of my natural physiological T level. Unfortunately most of us do not have this datum. What can we do? We use the population normal distribution as reference. I would use the population...
  22. Seagal

    TRT+ other medications

    Yes, it works for you. Perfect. I'm not judging, how could I based on the scarce scientific data. Table 2 baseline T levels: mean +- SE. There is variation between individual baseline levels. There is no need trying to justify your dose. At least not from my perspective. It's not about the...
  23. Seagal

    TRT+ other medications

    My comment was about the (mis)interpretation of the study. Sticking to science and not making up things and jumping to conclusions that are not supported by the data. Everyone is obviously allowed to share his opinion and encouraged to share his experience. Everyone is free to experiment and...
  24. Seagal

    TRT+ other medications

    Exactly that. If anyone cares, look at the baseline peak levels. Table 2 and table 7 for hemoglobin and hdl. This work did not aim to find the TRT dose for the study population. Read the discussion, limitations etc.
  25. Seagal

    Neurobeachin (NBEA) is a novel gene associated with GLP-1 receptor agonist associated weight loss

    https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.16612 Abstract Aims Nearly 42% of adults in the United States have obesity, a significant risk factor for many cardiometabolic diseases and cancers. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are promising...
  26. Seagal

    TRT+ other medications

    I give up! AI succeeded humans in reasoning... I apologize for being rude. It's just so frustrating.
  27. Seagal

    TRT+ other medications

    "My priorities are I want to keep the ability to perform in the bedroom, at the gym and not go through life having zero energy, brain fog, 2nd guessing and able to make a decision on anything." = TRT But that's not what you want: "Compared to where I was. 500ng/dl is amazing. But I don’t have...
  28. Seagal

    Erythritol adversely affects brain microvascular endothelial cell function

    Especially if one aims to prioritizes brain/mental health.
  29. Seagal

    Erythritol adversely affects brain microvascular endothelial cell function

    https://journals.physiology.org/doi/full/10.1152/japplphysiol.00276.2025
  30. Seagal

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    This comment was financially supported by The FunkOdyssey Makeover Clinic
  31. Seagal

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    I should have written that this comment is not related to your discussion (more to Vince's post and in general there is often a bias towards physique). I was amazed how long you both discussed in a civilized manner. Bravo Yes, I think to know that there is dose relation to symptom relief...
Buy Lab Tests Online
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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