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Low dose enclomiphene combined with Low dose TRT
It doesn't really support the assertion by @aneuman of no suppression below 5 mg exogenous T per day. FSH levels in 17 of 18 individuals receiving at least 5 mg testosterone per day were at or below prepubertal levels (4.59± 0.17) (13) ... At no time were levels of LH and FSH higher after...- Cataceous
- Post #43
- Forum: Testosterone Basics & Questions
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Androgel Failed and rose PSA
Due to individual variation there's no fixed answer. In switching to injections you will likely produce less DHT, which could be helpful. But it's also easier to attain very high testosterone levels with injections, which could be counterproductive. Your best bet is to start injections with a...- Cataceous
- Post #2
- Forum: Testosterone Basics & Questions
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Bigger testicle size, LH vs HCG?
It seems likely to be true, especially if you stipulate similar LH/hCG activity. But a comparison between endogenous LH and exogenous hCG isn't exactly straightforward.- Cataceous
- Post #2
- Forum: Testosterone Basics & Questions
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Progesterone Dose for Men
Is this figure based on any rigorous accounting? But assuming it is correct, perhaps it matches the fraction who didn't bother to monitor serum levels and titrate the dose accordingly. The supposedly low topical progesterone dose of 10 mg per day yields 1 mg absorbed per day at 10% efficiency...- Cataceous
- Post #537
- Forum: Thyroid, DHEA, Pregnenolone, Progesterone, etc
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Progesterone Dose for Men
On the plus side, I think the article helps to emphasize the importance of achieving and maintaining a good balance between progesterone, testosterone, DHT and estradiol. On the minus side, promoting a progesterone product on the same page does somewhat diminish its credibility.- Cataceous
- Post #535
- Forum: Thyroid, DHEA, Pregnenolone, Progesterone, etc
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Testosterone dosing amounts in postmenopausal women?
Thanks for the added information. In my understanding, progesterone isn't essential for her both because there's no uterus to respond to estradiol and because the vaginal cream has limited systemic activity. It's different for women with a uterus starting systemic HRT, and I'm curious about how...- Cataceous
- Post #8
- Forum: HRT in Women
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Testosterone dosing amounts in postmenopausal women?
Yes, 5 mg per week isn't a bad starting point, ideally in divided doses. That translates to 0.5 mg of testosterone per day, which is perhaps a little high relative to natural production, with various sources suggesting 0.1-0.4 mg. It's possible that adding testosterone will also increase...- Cataceous
- Post #4
- Forum: HRT in Women
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Test Prop / Test Cyp?
Blending propionate with a longer ester such as cypionate or enanthate is a good choice if you're going to inject daily. Propionate alone causes an unnaturally large variation in serum testosterone, while a longer ester usually leads to an unnaturally low variation. There's a long thread here...- Cataceous
- Post #2
- Forum: Testosterone Basics & Questions
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SERM to Increase SHBG
If you're US-based and in the right state then you can support the site sponsor: https://www.discountedlabs.com/free-estradiol-sensitive Alternatively, free estradiol can be estimated with a calculator: https://www.excelmale.com/threads/spreadsheet-for-calculating-free-t-e2.17216/- Cataceous
- Post #8
- Forum: Testosterone Side Effect Management
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How to raise free T
That's not what he said. He said that changing SHBG is not going to change free testosterone, only total. It's great to see a doctor who understands this.- Cataceous
- Post #10
- Forum: When TRT Is Not Enough (ED, Libido, & More)
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Minimizing Erythrocytosis during TRT (Daily injectable Testosterone vs. Gels vs. Kyzatrex)
Disagree. I counter your anecdote with my own. I do better on lower doses and I have actually tried a wide range of physiological doses..- Cataceous
- Post #15
- Forum: Testosterone Side Effect Management
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TNE (test base) once daily timing to preserve HPTA function
It would be very helpful to the TRT community to have a better understanding of the pharmacokinetics of TNE. Our best guess is that TNE is not as fast acting as nasal gels and buccal troches. This could make it comparable to some of the oral formulations. In any case, it would be great to have...- Cataceous
- Post #4
- Forum: Testosterone Basics & Questions
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Normal Total Testosterone, Low Free T and E2 - Would you start TRT?
The direct free testosterone test correlates poorly with better methods and should not be used. Nonetheless, the Vermeulen free testosterone calculation also points to lowish numbers. Your total testosterone is artificially boosted by your highish SHBG, and therefore is not useful as an...- Cataceous
- Post #4
- Forum: Testosterone Basics & Questions
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Advice of Lab Results-High Estradiol
Evidence? For what it's worth, ChatGPT agrees with me. Reference ranges are supposed to be representative of the healthy portion of the subject population, not the entire population. Identifying who is healthy is the tricky part. 4. Challenges in Establishing Normal Ranges: Finding a truly...- Cataceous
- Post #23
- Forum: Blood Test Discussion
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