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  1. C

    Blood panel, how's mine look?

    The Androgel experience ended up being poor, primarily due to absorption issues. After that decent TT measurement the next one was 160 ng/dL. Even as a trough value that's not viable. Injections were an improvement, yet far from "the answer". Admittedly one of the few things I've haven't tried...
  2. C

    Blood panel, how's mine look?

    That smoking analogy is only meant to highlight that a possible risk factor should not be dismissed just because causality is not yet established. Testosterone levels are associated with a U-shaped mortality curve in some studies, particularly in men. Research indicates that both low and high...
  3. C

    Blood panel, how's mine look?

    A one-size-fits-all approach is a doctor who gives all his patients 140 mg TC per week right from the start. And from there his plan is bloodletting to control cases of high hematocrit and AIs to address symptoms of high estradiol. This results in unnecessary suffering by many of his patients...
  4. C

    Blood panel, how's mine look?

    There's this complexity, and probably even more. I have dabbled with anastrozole when my TRT dose was higher, and I also had a period with very low estradiol for some other reason. I don't recall that these had much effect on motivation. The anastrozole would dampen excessive emotionalism. Very...
  5. C

    Blood panel, how's mine look?

    Is the "one size" my counsel for moderation when starting out? If so you're acting as though the low-and-slow approach to hormone replacement—and often to meds/supplements in general—is some weird idea I came up with at random. Do you remember John Crisler?
  6. C

    Blood panel, how's mine look?

    It's absurd to characterize a normal range that encompasses at least 95% of the population as "one size". Furthermore, as a long-time resident here you should be well aware that being an outlier is problematic, and is associated with reduced longevity and other problems. You've convinced...
  7. C

    Blood panel, how's mine look?

    The usual straw-man nonsense. Let me fix that for you: "Physiological testosterone levels equal better health."
  8. C

    Blood panel, how's mine look?

    Actions speak louder than words. Even Defy Medical seems to routinely start guys with well over 100 mg TC/week. Yet the available evidence does not support this approach when overall good health is the goal. It's easily inferred that this is a result of more-is-better thinking specific to...
  9. C

    Blood panel, how's mine look?

    I think compared to hypogonadism even dated TRT protocols would provide some relief. But you must be aware that nobody around here is going to recommend taking 200 mg TC once every two weeks. It's not an assumption, but standard medical practice for just about any hormone other than...
  10. C

    Blood panel, how's mine look?

    That's a bit of a hit-and-run. I'm prepared to defend my hypotheses, particularly the one saying that a starting dose of 100 mg TC/week is excessive. The main caveat is that these high doses came about due to the assumption of infrequent injections—once or twice a month to once a week. Under...
  11. C

    Blood panel, how's mine look?

    For quite some time I was using 18 mg TE EOD, which resulted in TT of ~800 ng/dL, SHBG ~30 nMol/L. Vermeulen calculated free T was around 20 ng/dL, which puts it in the mid to lower part of the top quartile for healthy younger men. The worst symptom I'd link to this was a persistent headache. It...
  12. C

    Blood panel, how's mine look?

    By conventional standards I was never on high doses. But when I started out with 100 mg testosterone cypionate per week delivered EOD it put TT at about 1,250 ng/dL. Thanks to the influence of the late Curt Moyer I knew this was higher than I wanted, and titrated down to more like 65 mg/week...
  13. C

    Blood panel, how's mine look?

    I would guess at least 1,200-1,300 ng/dL for your peak. It is considered standard practice to test at trough, but then you do need to keep in mind that the peak is a lot higher with weekly injections. With twice-weekly injections peaks may be more like 50% over troughs. To some extent testing at...
  14. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    I don't know the practical limitations on particle size for testosterone suspension. Maybe there's a cost-benefit tradeoff? In addition, the interest in very fast-acting testosterone is more recent and still limited. Bear in mind that testosterone basically does not dissolve in water. However...
  15. C

    Blood panel, how's mine look?

    Your instincts are good with respect to dose frequency. With once-weekly doses of testosterone cypionate it's common to have peak levels that are two to three times trough levels. This is decidedly unnatural. Assuming your lab work is at trough then you are likely going from very high to mid-low...
  16. C

    How BMI Influences Testosterone Boosts: Up-Titration Results for Oral Testosterone Undecanoate

    Apparently this study did not track free testosterone, which makes the results considerably less useful. Higher BMI is expected to correlate with lower SHBG [R], which leads to lower total testosterone for the same level of free testosterone. Therefore these cohorts with different BMIs could...
  17. C

    Clomid for Testicular Shrinkage ?

    The most common cause of thyrotoxicosis in pregnancy is gestational transient thyrotoxicosis (GTT), which occurs from the stimulatory action of human chorionic gonadotropin (HCG) on the TSH receptor. https://pmc.ncbi.nlm.nih.gov/articles/PMC4166486/ Interesting. There's always something new...
  18. C

    The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)

    I can't say with certainty, but I think it's associated with improved mood and motivation. There are no side effects that I'm aware of.
  19. C

    The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)

    I do take it orally, on waking with an empty stomach.
  20. C

    The significance of selegiline/(-)-deprenyl after 50 years in research and therapy (1965-2015)

    Yes, I've been taking 2.5 mg/day consistently.
  21. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    I've taken the first one, which is to investigate where the missing testosterone went. It appears likely that the filtering action of a small needle is part of the problem, along with wastage via particle deposition on the vials. The empty vial that had contained 1 mL of the TS and 1 mL of...
  22. C

    Testosterone no ester

    If you're including testosterone suspension in this then yes, I am using it as a form of TRT. As documented here, I recently tried measuring the response over time. My protocol has involved injecting a nominal 1.5 mg three times a day. But based on lab work I'm beginning to suspect the actual...
  23. C

    Building a TRT protocol around hCG

    This is very much in line with my thinking, particularly the part about a longer HTPA shutdown being more problematic. In my case the addition of hCG was an improvement, but it never led to consistent libido and/or sexual function, and things still went downhill over the years. Dropping the hCG...
  24. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    Lately I’ve been insinuating that some testosterone suspension products may qualify as fast-acting, and therefore be in the same league as testosterone nasal gels and buccal troches. The “fast-acting” quality is important if the goal is to retain HPTA function in the presence of exogenous...
  25. C

    Advice on next steps - mid-low free T

    I do believe that TRT in just about any form is preferable to hypogonadism. However, now that we have an increasing number of choices that are less disruptive of the overall hormonal milieu I would hope these eventually become the new standard of care.
  26. C

    Advice on next steps - mid-low free T

    These are all relatively short and with small N, as they acknowledge: "A large number of clinical trials with relatively small numbers of participants, have been conducted to investigate the effects of testosterone, for generally limited durations of intervention, on various cognitive function...
  27. C

    Advice on next steps - mid-low free T

    As noted, GnRH may play a role in adult neurogenesis. Also in the post I linked to: ”[1] Furthermore: “Multiple lines of evidence indicate that the expression of extrapituitary GnRH receptor is not limited to reproductive tissues. For instance, it has been demonstrated by RT-PCR and Southern...
  28. C

    Advice on next steps - mid-low free T

    Which studies evaluated the rates of dementia? Healthy controls or just untreated hypogonadal subjects? What's needed to answer this question more definitively is a study with large N that has matched eugonadal men as controls. The study needs to last long enough and/or have old enough subjects...
  29. C

    Adding Anastrozole, how much should I lower dose?

    Regardless of whether the testosterone is endogenous or exogenous, the fraction that is aromatized is trivial, and you'd be unable to detect such an increase, subjectively, or even with current lab tests. On the other hand, knocking down a big fraction of estradiol is what can cause significant...
  30. C

    Advice on next steps - mid-low free T

    That's good to know and nice work by Maximus. It sounds like I may be able to add it to the list of short-acting testosterone treatments. I still don't like the use of the term "bioidentical" to differentiate it from products that in the end also yield bioidentical testosterone. "Non-esterified"...
  31. C

    Adding Anastrozole, how much should I lower dose?

    DHT is created from free testosterone. The rate of creation is not expected to change with lower estradiol. This means free DHT should not change. But as with testosterone, if SHBG is driven down by the lower estradiol then total DHT may drop. I should add that I'm ignoring the tiny amount of...
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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