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  1. C

    TRT+ other medications

    Because virtually nobody is producing 12 mg of testosterone per day naturally. This mischaracterizes what I said. It may not be optimal for a slight majority, but in divided doses it would resolve some of the worst symptoms of hypogonadism. The reason for the low-and-slow approach is that many...
  2. C

    TRT+ other medications

    Wrong. Virtually nobody is naturally producing 12.5 mg T per day, so 125 mg TC/week is decidedly non-physiological for anybody. People like you can tolerate it, but that doesn't change my position that it's foolish to start "TRT" with such doses, and it's unlikely that such doses are optimal for...
  3. C

    TRT+ other medications

    Yet this phrase seems to come up when people want to skip directly to high doses without bothering to explore the physiological range first, which ironically is treating by numbers anyway. Yes, there are plenty of testimonials about the harm done in trying to make bigger doses work, as with...
  4. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    In theory, though it could be overstated. It would imply that a 1 mg dose would raise TT by around 2,000 ng/dL. I might use this dose for testing next time—in order to improve the signal-to-noise ratio. I'm not even going to attempt HPTA suppression, but if TT levels really hit well over 1,000...
  5. C

    TRT+ other medications

    This is highly misleading due to using trough values on weekly injections. That 125 mg dose is supraphysiological except near the end of each injection cycle.
  6. C

    TRT+ other medications

    Unfortunately your priorities are likely at cross-purposes. Some nontrivial fraction of men must choose between overall health—and sexual health in particular—and high-level physical performance. You can read about the experiences of others in this post. I would argue that your doses are above...
  7. C

    Pharmacokinetic Profile of Testosterone Suspension: A Case Study

    Here's an interim update on this research. It had become clear that if I wanted to continue using small-gauge needles, e.g. 31 gauge, then I needed to create an aqueous solution; the particle sizes in even partial suspensions were too large to get a predictable dose. A new formulation that...
  8. C

    How can I regain my libido without side effects?

    There is a possible middle ground, which is topical finasteride, along with topical and/or oral minoxidil. I had unpleasant side effects from oral finasteride, and it took some time to make the connection and then recover. But as hair loss resumed I eventually gambled on going the topical route...
  9. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    As the point-by-point rebuttal has gotten repetitive, I'll skip to this, which I agree is the crux of the matter. In the end you've provided no evidence that there are advantages to starting TRT with this higher, non-physiological dose. In contrast, I have shown that lower starting doses can be...
  10. C

    TRT Dose question

    Trough levels on testosterone cypionate do tend to rise with a higher injection frequency—and variation decreases. A propionate blend given daily is a different animal. You would adjust the dose to give you an appropriate peak level, which you get within a few hours of the injection. The...
  11. C

    TRT Dose question

    If you're sufficiently motivated then a logical progression in the experimentation is daily injections of a cypionate/propionate blend. Then you remove the variation across different days and you can focus on how each day should be. With a blend you can control how much daily variation you want...
  12. C

    Experiences and Questions: Personal Experiments with Oral Native Testosterone Base & Enclomiphene (TRT+), Testosterone Propionate, HCG and more

    I post this occasionally to remind people to be careful with making inferences from LH measurements. Overall there's going to be a correlation with testosterone. But with any single measurement you don't know where you are with respect to the pulses. Endogenous testosterone is going to be like a...
  13. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    They are, but that should read "high starting dose". You added a "majority of men" qualifier. I'm not claiming to have quantified the rate at which men have problems at this dose. My point is that a midrange dose, say 50-80 mg TC/week, is less likely to cause side effects. While the general...
  14. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/209863Orig1s000SumR.pdf Nonetheless, it makes sense to titrate to the center of the healthy normal distribution for initial dosing. That's not a claim I have made, though it would undoubtedly be true if out-of-range free testosterone...
  15. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    That's patently false. I called the 60-70% figure a rough guess initially and then provided the statistics to back it up, showing a more accurate number was only 5% outside of my estimated range. And speaking of prevarication, as long as we're letting AI do the heavy lifting for us: - However...
  16. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    Some interesting stuff there, but I suspect it's far from complete. More discussion of testosterone's link to antisocial effects is needed. A small point, but I have to somewhat question the statement that "even modest increases in lethal cancer late in life would select against chronically...
  17. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    Cite at least three of the "numerous studies" showing people doing "really well" long-term at these doses. A few months of dose-response testing doesn't count. What is really telling is the high churn rates for the standard forms of TRT, including injections, which at least prior to Xyosted were...
  18. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    I do recognize that my preferred strategy of starting at the lower end is unlikely to be adopted. If you read my posts you'll see that my actual recommendations are for starting with mid levels, 60-70 mg TC/week or so. Anything to get away from the stupidity of starting at 100+ mg. If you insist...
  19. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    We could debate ad nauseam where such a cutoff should be. But you're just trying to evade my main argument, which is that there's no justification for starting TRT at high-end doses. You haven't even attempted to refute this in any serious, science-based fashion. Using excessive amounts of...
  20. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    I noted that one reference range for daily testosterone production is about 3-9 mg. That translates to 30-90 mg TC per week. If you want to go by anecdotes then there are a "TON" of guys who suffer from supraphysiological and even high-normal dosing. I've already linked to the list twice in...
  21. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    No, according to me, 50 mg TC/week (5 mg T/day) is a mid-level physiological dose. This is in the context of typical production for healthy young men of 6-7 mg/day, and an overall reference range of something like 3-9 mg/day. I have used as little as 3.7 mg T/day in the form of a TP/TE blend and...
  22. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    The main problem I have with this is that you have no idea what physiological doses are like. What you haven't demonstrated is that one can compensate for the differences between endogenous and exogenous testosterone simply by giving more exogenous testosterone. I would argue that such...
  23. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    Stop to think about this. There's no reasonable basis for ruling out most of the physiological range for dosing. Don't succumb to pressure from those who are simply rationalizing their excessive doses. Suppose you would feel the best at 60-70 mg per week in divided doses? We haven't emphasized...
  24. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    The usual more-is-better thinking that leads to a total loss of objectivity and harms many. Not sure why you say this when: the dose is more testosterone than all but a small fraction of men could produce naturally; it's probably on the order of double what the OP would have produced at his...
  25. C

    AI & E2 rebound effect?

    There's minimal, if any, research on this. I asked Grok to speculate on the time frame, assuming the effect exists. It was guessing from a few days to a week for any significant effects, with full equilibrium returning within two weeks.
  26. C

    First set of Follow Up Labs since Starting TRT. Looking for Feedback

    You already know the answer. https://www.excelmale.com/threads/starting-trt-soon.32170/post-296946
  27. C

    Lithium

    This isn't necessarily relevant and could get people into trouble. Some of these products contain 450 mg of lithium carbonate per tablet. Lithium carbonate is about 19% lithium, so you're talking about 85 mg of lithium. In contrast, this thread is talking about doses ranging from around 0.3 mg...
  28. C

    Lithium

    I've been getting about a milligram daily of elemental lithium via lithium orotate for some years now. I can't claim any very noticeable effects, but it seems worthwhile to take due to the positive associations and claimed protective effects.
  29. C

    Blood panel, how's mine look?

    Wrong on both counts. Follow the links. https://pmc.ncbi.nlm.nih.gov/articles/PMC8631164/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11070513/
  30. C

    Blood panel, how's mine look?

    Coincidentally the main forum page currently has threads by @madman highlighting research with cautionary statements about the effects of androgens on the brain. It might be argued that a lot of this applies only to doses well in excess of the 100-200 mg TC per week that I complain about...
  31. C

    Blood panel, how's mine look?

    I'd say it's better to use them concurrently, at least as adjuncts to TRT; they should be strictly complementary. The reasoning is that kisspeptin provides both kisspeptin and GnRH signaling. Negative HPTA feedback affects kisspeptin production more than its action, meaning exogenous kisspeptin...
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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