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Something i've noticed that seems fairly consistent with me - i always get morning wood, plus a stronger libido during the day, if i've had melatonin the night before. I didn't take any last night (i take it during the night if i wake up, rather than right before bed), and i didn't have morning...

https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02738-6?fbclid=IwQ0xDSwLN7BNjbGNrAs3r_GV4dG4DYWVtAjExAAEeDoUZK3-crAureufrldyGa317s2-88AuSe80E43lhe4eUq9zcxmKWaaRpTo8_aem_ZtYJUzUud24eprLKcq3f6w Quoting from the summary on Suppversity - "How does it work? The anti-obesity...

Melatonin Supplementation Enhances Next-Day High-Intensity Exercise Performance and Recovery in Trained Males: A Placebo-Controlled Crossover Study Background/Objectives: Sleep and recovery are critical for optimising exercise performance. However, the efficacy of melatonin supplementation in...

Bit odd the f/book link was censored?..

Interesting post on Suppversity f/book page - low sodium levels can cause anxiety behavior (at least in mice) due to reduced dopamine and serotonin https://www.********.com/share/p/1CzPKyUQwM/ Post links to this article -...

Ibutamoren is definitely not for me - i tried 5mg yesterday, in the morning this time. Within a couple of hours, i felt 'off' mood wise. That evening, i struggled to eat my dinner and ended up throwing most of it in the bin. My sleep last night was even worse than the night i tried 10mg -...

I'd totally forgotten about this discussion between you and i @Gman86 only a couple of months back - i was just doing a search here and on google about coming off ramipril, and this thread popped up. Very helpful, as once AGAIN my gp service has blocked me reordering my repeat prescriptions...

So, i tried my first dose of ibutamoren last night, 10mg, and was very much looking forward to the enhanced sleep i keep reading about. Ended up having the worst nights sleep in ages, totally 'tired but wired' type feeling. I gave up around 4:30am and got up. Not the sleep result i was expecting...

Thanks for the reply @Cataceous. I was considering giving it a try (same, low dose of 10mg) as i reacted badly to ipamorelin and mod grf 1-29 when i tried it. Someone in another thread mentioned that ibutamoren (somehow) helped with their shoulder impingement, which i have. Plus, it's potential...

Hi @Cataceous - curious about you adding the ibutamoren. How are you taking this, fasted, or with/near a meal? Is there any concern about it affecting blood sugar or causing insulin resistance at that dosage? If so, are you taking anything (metformin, berberine etc) to control that?

Was the blood test an at home, finger prick test? I've read they can be very off with results if that's what was used.

Brilliant, good luck with that! If you're interested, that Dr Somerville has his site with his blog on it - Home - Dr. Judson Somerville

Yes, i am (more 'was') also concerned about possible toxicity. I'd been taking 5000iu for many years, but in the past year my rheumatic thumb joints have been causing me a fair amount of trouble. I found out about a dr using 30000iu plus to treat autoimmune diseases, and started looking into it...

I had a similar 'conversation' with chatgpt yesterday, started by asking for any clinical evidence of the effectiveness of cissus quadrangularis for joint pain. Then got onto its evaluation of the high dose vitd3 i use to combat the rheumatism i get in my thumb joints. Here's a copy/paste if...

Ah yes, i can imagine. I was looking as i'd just ordered some *** flower to try in my dry vape. I usually have a small amount of regular, hybrib weed before bed. I've tried c*d before as oil caps, and wasn't impressed (this is the UK though, so not going to be the strength or quality you get in...

I find it odd that the letters 'c' 'b' & 'd' get edited/censored to '***', but THC doesn't!! Might explain why when i tried to search it on the site, i got no results, but searching the site through google gave results (as ***)

Thanks Nelson

Over the last week or so i get the accept/decline cookie pop up on every page i go to here. Even after i've selected 'accept' or 'decline', once i go to another page, i get it again. Is there any way to stop this?

The study above though is relating to people on trt - a reduction in LDL levels in those on trt only with higher vit d levels was one finding

https://www.mdpi.com/2072-6643/17/6/1013 Conclusions: The study results suggest that the cardiometabolic effects of exogenous testosterone in men with testosterone deficiency may be determined by vitamin D status.

Totally agree with you about serotonin. Years ago, my gp at the time prescribed me an ssri (paroxetine) when i said i was having trouble sleeping due to stress. "You'll feel great too" he told me..... Second worse med i've ever taken (i binned them after a few weeks) - only one worse than that...

Just realised the email info also opens up on the web - https://chrismasterjohnphd.substack.com/p/methylene-blue-on-the-airplane?utm_source=post-email-title&publication_id=752142&post_id=161243673&utm_campaign=email-post-title&isFreemail=true&r=1d69zf&triedRedirect=true&utm_medium=email

What a coincidence - i was reading this thread earlier today. @Guided_by_Voices mentioned Chris Masterjohn a couple of posts above, who i follow and get emails from. And just now, he's sent out a really long email all about methylene blue. I can copy/paste it if anyone's interested, it's long...

Blimey, that's a bit scary to be honest. It's great the way it comes back with answers in a conversational way, like chatting to a friend. Just it's one of those friends that aren't as bright as they think!!

I gave chatgpt the link to your site, asked it to read what's there, then give me an easy to understand summary instructing how to raise ferritin on trt. This is what it came back with..... ChatGPT said: Testosterone Replacement Therapy (TRT) can lead to erythrocytosis, a condition...

Thanks for that, some great info there. I actually already do some of it (been a supplement junkie since childhood) - i take around 600mg of magnesium a day (glycinate / malate / citrate combo), currently 10,000iu vit d3, vit k2 (mk7 plus mk4), 200iu mixed tocopherols, cod liver oil for vitA...

I'm actually having to go in tomorrow for a blood test and to have my blood pressure taken. They've been texting me for the past two weeks to book myself in, but because i ignored them, yesterdays text said they couldn't issue my next prescription until i've had it done (i'm on ramipril for...

No idea tbh, i don't think i'd take dietary advice from any of the doctors from my gp surgery though. For starters, most of them are obese. Recently, after trying to peddle their statins on me due to slightly elevated cholesterol (i refused them), i was asked about my diet. I mentioned i eat...

Having just read through (most of) this, i thought i'd ask chatgpt about ferritin levels and thyroid. Gotta say, it's good fun using AI, (although i do know the answers to questions aren't always right). You said: Do ferritin levels affect thyroid? ChatGPT said: Yes, ferritin levels can affect...

https://www.sciencedirect.com/science/article/abs/pii/S0899900722000867 Quote: Highlights • Improving magnesium and vitamin D status concomitantly in the overweight or obese population may lead to greater improvements in cardiometabolic outcomes than vitamin D supplements alone • Participants...

https://pmc.ncbi.nlm.nih.gov/articles/PMC7861592/#:~:text=Magnesium%20is%20Required%20to%20Activate%20vitamin%20d&text=Thus%2C%20optimal%20magnesium%20status%20is%20required%20for%20optimal%20vitamin%20D%20status.&text=Both%20magnesium%20and%20vitamin%20D,necessary%20to%20activate%20vitamin%20D...