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Dr. McClain: Many thanks for taking time to answer questions on this forum. Very rare for a MD of your expertise to do this freely and openly. Very unselfish on your part! Also thanks to Nelson for putting this together for all of us members with some very good questions that we can't find...

Here is a good link to blood test needed before and during testosterone treatment. Estradiol Sensitive test should be included at least to have a starting point. https://www.excelmale.com/forum/showthread.php?5040-Blood-Tests-Needed-Before-and-During-Testosterone-Replacement-Therapy

Are you taking an AI?

Only way to know for sure if its the HCG causing your symptoms is to quit taking it for 2-3 weeks, then see how you feel. I am a patient at Defy as well and any MD or nurse will tell you if you are having severe side effects since beginning a new protocol, then cease taking the meds and see how...

You can discontinue the HCG for 2-3 weeks and see if you feel better. If not, then its not the HCG causing your symptoms. I had similar symptoms and discontinued HCG and after 2-3 weeks symptoms started to improve so, no longer on HCG. You can check out some of the side effects of HCG here...

Try getting an appointment with a urologist or endrocrinologist. I waited 3 mos to see an Endo and he didn't have a clue. Be patient. Defy's staff & care well worth the wait.

HCG did nothing for me. As a matter of fact I felt worse while taking it, allergy symptoms, fatigue, nothing for the boys that I could tell. I was on 250IU EOD for about 2 years. Decided to stop and see how I felt and started have a little more energy and allergies decreased. It may work...

You can wait until your refill but, if symptoms persist and are taking a toll on you, you can request Defy to send you a return envelope, you put your remaining TCyp bottle in it and send it back to Defy. Once it is received, they will order a new vial with sesame oil. Since Testosterone is a...

Could be the cottonseed oil in the Sun Pharma TCyp. Checked the drug label and it is showing each 1 ml has 736 mg of cottonseed oil. Hallandale Pharmacy most likely compounded with grapeseed oil. Compounding pharmacies cannot use same oil as big pharma uses so, they compound with either...

Could it be the HCG? According to WEB MD, side effects are headaches, tiredness, restlessness are the common ones with swelling in ankles/feet, mental/mood changes i.e. depression are listed as serious side effects. I too have had good numbers but, just didn't feel right with fatigue...

Campo email Sam or Melissa at Defy and they can get you a script for a phelebotomy. They will not prescribe any refills until you donate blood. Been there done that and the wait can be a pain! They can also get you a prescription for Metformin that you can take to your local pharmacy to have...

How long have you been on T therapy? Water retention and bloating are common side effects at beginning but, slowly decreases as your body adjusts. Here is a good sticky by Nelson that explains water retention has nothing to do with estrogen...

Why not get your policy and read the section on blood test coverage? It should be spelled out

Absolute you make a valid point. His symptoms started at week 7 if I understand the post correctly. I was originally on pellets compounded with grapeseed oil. The first couple months, was fine. Then started having severe sinus congestion, and other allergy symptoms. Its like an Allergist...

Clicker you may have an allergy to the grapeseed oil itself. Since it has been 7 weeks and you are still having side effects, I doubt if it will get any better. I myself have been on TCyp with grapeseed oil, sesame seed oil and finally cottonseed oil and had allergic reactions to all 3...

You are applying correctly however, Defy's website list 4 areas to apply creams to. Here is the link: http://defymedical.com/component/content/article/services/288

Pacman Defy has some pretty good instructions on how to use the Top-Click, where to apply and other important questions answered. Check this out: http://defymedical.com/component/content/article/services/288. They state to wait 40 minutes after applying to shower.

I have a degenerative disc at L4-L5 and a bulging disc at L5-S1. Was in severe lower back pain for a long time until I did these 3 things: 1. Purchased a Sleep Number mattress and set it as firm as I could. 2. Found an excellent massage therapist and a chiropractor. 3. Sleep on a heating...

choppa: .15ml or 60 mg 2 x week... I have high SHBG so need lower dose and I am still tweaking dosage. Going to up it to .17 ml or 68mg 2 x week since 60 mg week only got my T levels up to 831... I need to be in the 1100 range to have functional free T.

You can always use a money order for exact amount. Routing number and account number pretty much same as a check and, very safe.

I also took too much anastrozole and my E2 tanked to 8.4 on a 1/30/17 blood test. It rose to 14.9 on 2/28 and to 20.6 on 4/14 so by now I'm thinking I'm around 25-30 which is perfect for me. So took about 3 months. Hang in there - it is quicker than you think but it will follow T as CW said.

I would hope so but with several medical websites listing "blood clots" as a serious side effect so maybe there is a connection. Hopefully Dr Saya or Nelson can add to this. IMHO, blood clots is a thickening of the blood and that is what elevated HCT is I think.

giannid - Many of us here feel your pain. My HCT has spiked and have already had 3 donations this year so far. Very weird to me since I was on pellets from Nov 2014 with another mens clinic before moving to Defy in June 2015. I started TCyp shots in Sept 2015 when my T levels dropped to 591...

I was with another T clinic before finding this site and Defy. Took me 9 months to finally get started with them and have been very very pleased with service and medical advice. From your blood work, your free T is low at 7.9 and your VitD is on the lower end. The suggested 250mg of...

It would be interesting to hear from the experts here at EM their views on hematocrit levels published in this study. LabCorp ranges are 37.5 - 51.0. With Defy, if your hematocrit rises above 51, you are to immediately have a phlebotomy where this study states "phlebotomy maybe necessary to...

Re-Ride just now saw your post about NAC and blood pressure. Did stopping NAC improve your BP levels? I'm also taking NAC and my BP has jumped. Many Thanks!

Jake I would give it a couple more weeks. It could be just a reaction to the T itself or, you could have a flu bug. If problems persist and do not get better, it may be an allergy to the oil used in the compounded T. If from Defy, it is probably compounded with grapeseed oil. Do you know...

Dr Rotman what disease state contributes to high SHBG? I always thought this was mostly hereditary.

Dr Rotman what disease state contributes to high SHBG? I always thought this was mostly hereditary.

Furry it may be an allergy to the type of oil your T is compounded with. I originally started on pellets with grapeseed oil and after about the 4th month began to have flu like symptoms - head colds, sinus infections, chest congestion, body aches, etc... This continued after I switched to Defy...

That makes sense CW. Thanks for the info!