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Good to hear that our suggestions worked !

https://www.ema.europa.eu/en/news/measures-minimise-risk-suicidal-thoughts-finasteride-dutasteride-medicines

First of all, make sure you are using LC/MS when testing for progesterone and pregnenolone if you want accurate numbers. Scraping Excelmale : Testosterone replacement therapy (TRT) lowers upstream hormones like progesterone and pregnenolone primarily due to its suppression of luteinizing...

You may want to read this post: https://www.excelmale.com/threads/fixes-for-joint-issues-a-list-of-some-basics.17543/

On the other hand … https://www.healio.com/news/womens-health-ob-gyn/20250507/for-some-women-with-infertility-glp1s-may-hold-an-unexpected-benefit-pregnancy

Your hematocrit is probably 54 and you are taking a relatively lower dose. I would not worry too much. Make sure next time you get blood drawn that you are well hydrated. Some guys say narigin supplements help. https://www.discountedlabs.com/blog/lower-high-hematocrit-strategies

The most effective and fast way to decrease hematocrit without blood donation is taking an ARB like losartan or others. https://www.excelmale.com/threads/can-losartan-decrease-high-hematocrit-caused-by-testosterone-replacement.3667/

In New Zealand, men on testosterone replacement therapy (TRT) who develop elevated hematocrit and require therapeutic phlebotomy face significant restrictions: New Zealand Blood Service (NZBS) Policy: Therapeutic venesection (phlebotomy) is generally only provided for specific conditions such...

Tell them you want to pay cash. From perplexity: Men on testosterone replacement therapy (TRT) can develop elevated hematocrit (erythrocytosis), which increases the risk of blood clots and other complications. In many countries, therapeutic phlebotomy (removal of blood to reduce hematocrit)...

https://www.excelmale.com/threads/trimix-while-on-blood-thinners-like-apixaban.32003/

TRT & Fertility: The Basics Exogenous testosterone or AAS can shut down gonadotropins, leading to azoospermia in ~10 weeks¹Excel Male TRT Forum. After stopping, half of men regain fertile sperm counts (~20 million/mL) in a median 3.7 months²PMC. Start Smart: Pre-TRT Checklist Obtain...

Latest data https://www.contagionlive.com/view/pneumonia-antibiotic-cures-lyme-disease-at-doses-100-times-lower-than-standard-treatment

On TRT: "In all cases, bioavailable testosterone levels should also be monitored as testosterone therapy lowers SHBG". https://pmc.ncbi.nlm.nih.gov/articles/PMC2701485/#ref-list1

The references were inbedded in the content: NO TRT (normal physiology): Sex hormone-binding globulin profoundly influences the distribution of testosterone between bound (inactive) and free (active) forms. Under normal physiological conditions, SHBG helps determine an individual’s total...

To be honest, I do not see how Grok 3 would disagree that rules that apply to "normal physiology" not necessarily apply to men on TRT. From Perplexity: ChatGPT-3 vs Grok 3 for Deep Medical Research Summary Table Feature/Capability ChatGPT-3 (o3) Grok 3 Depth & Technical Rigor Superior...

The above statement is only true under "normal physiology." TRT does not represent "normal physiology". Also, TRT does not lead to "normal physiology" when talking about "high estradiol". Example: The use of "normal" estradiol ranges that were derived from normal physiology (TRT-free) are...

Many people feel like not drinking alcohol or smoking. There is enrfung data on curbing addictions. All dopamine rushes.

https://www.excelmale.com/threads/glp-1-medications-semaglutide-etc-decrease-sex-drive.32261/

Study at a Glance Title: “Assessing the Impact of GLP-1 Receptor Agonists on Sexual Desire: A Qualitative Review” Authors: H. Quaile & R. Horwitz Journal: Journal of Sexual Medicine — published 1 April 2025 Why This Matters Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as...

He mentions it here: https://www.excelmale.com/threads/empower-pharmacy-ceo-shaun-noorian-challenges-big-pharma-over-glp-1-drug-access-and-pricing.32218/

Thanks, Vince. I did not know! I pulled some more info from Deep Research. In short: Yes—several well-designed observational studies (including two meta-analyses) report a statistically significant but generally modest positive association between higher circulating vitamin B12 (cobalamin) and...

Sex Hormone Binding Globulin (SHBG): Appreciating Its Function in Men's Hormone Health Overview Sex hormone binding globulin (SHBG) is a protein frequently discussed in conversations about testosterone, libido, and muscle gain. If you’re on a testosterone treatment journey or active in...

I just found out that Belmar got approved.

What is the maximum (toxic) dose of B-12? No formal toxic (lethal) ceiling has ever been identified for injectable vitamin B-12. Because cobalamins are water-soluble and the kidneys excrete the excess, the U.S. National Academies declined to set a Tolerable Upper Intake Level (UL) for the...

https://www.excelmale.com/threads/what-type-of-b-12-vitamin-is-best.32256/

“Best” depends on what problem you’re solving, how often you want to inject, and what your pharmacy/insurer will actually supply. Below is a head-to-head snapshot followed by practical guidance. FeatureHydroxocobalaminCyanocobalaminMethylcobalamin Regulatory status (U S.)FDA-approved...

Could you please explain why GLP-1 medications are so popular and what they are? A class of drugs known as GLP-1s (glucagon-like peptide-1) has become very well-liked, especially because of how well they work to help people lose weight. This class of drugs, which includes tirzepatide and...

Vitamin D Status Shapes the Cardiometabolic Pay-Off of Testosterone Therapy in Late-Onset Hypogonadism Abstract Late-onset hypogonadism (LOH) is common in aging males and is frequently accompanied by features that drive cardiovascular and metabolic disease. Separately, vitamin D insufficiency...

Listen to this summary podcast: Empower Pharmacy vs. Big Pharma: GLP-1 Access Fight

Will check it out. Thank you.

That's awesome! I have been taking 5,000-10,000 IU per day for over 4 years and my PTH/calcium are OK. I will give 20K IUs a try and retest my PTH.