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Last point. To be clear I am not suggesting one should artificially lower estrogen. I am referring only to exogenous estrogen supplementation. I hope your spouse knows why it is being prescribed. If it is to treat symptoms of menopause or osteoporosis respectfully I believe that is a huge...

I have a bias, but one based on experience. I give weight to the bioenergetics / Ray Peat perspective. https://www.jayfeldmanwellness.com/ep-40-why-estrogen-and-birth-control-are-not-the-solution-womens-hormonal-health-part-1/

What is the reason for taking estrogen other than the doctor is terrible? Have her find the doctor who will advise her to stop the exogenous estrogen and start taking progesterone.

From Jay Feldman

That makes sense because propranolol and metaprolol are known for impairing melatonin production.

The conclusion seems axiomatic. In patients diagnosed with heart failure with preserved ejection fraction (a distinct subset of heart failure patients), withdrawing beta blockers resulted in short term increased exercise tolerance. I can't see the underlying study design to discern what...

Supposedly co-administration of oral GABA and vitamin B (B6?) increases ability of the GABA to cross the BBB.

It kind of makes sense. Think of the options. 1. normal sunlight; 2. synthetic sunlight; and 3. synthetic hormones. You're doing #3, but SHOCKED that a person would do the second option. The problem with just supplementing D3 is that you're going for balance. It's not all upside. The...

I have found it much easier to control Vitamin D with a UVB lamp rather than supplements. That would be the Sperti Vit D lamp. Alternatively you could build your own.

More evidence that increasing omega-3 increases inflammation. http://haidut.me/?p=2520 https://bmjmedicine.bmj.com/content/3/1/e000451

One other option is magnesium bicarbonate. Dr. William Davis explains how to make Magnesium Bicarbonate which is easily absorbed. Unfortunately almost all Milk of Magnesia now contains sodium hypochlorite. The solution is to buy magnesium hydroxide (I buy from Bulk Supplements) and just add the...

So Vitamin C increases absorption of non-heme iron. Therefore supplementation of Vitamin C with a high carnivore diet would not be the issue. But I ate vegetables too, so the Vitamin C could have been a factor. Here's Chris Masterjohn again. The link gets paywalled in about 36 hours...

Chris Masterjohn PhD just wrote a piece about ferritin in his Substack. Am posting below, but I'm not 100% sure it is not behind a paywall. The gist of what he writes is there's still much we don't understand about serum ferritin. Seems a bit of an understatement...

How can drawing labs at the same time as donation NOT affect the results if the samples follow the phlebotomy? At a minimum it adds a potential confounder.

My suspicion was that I was taking fairly high dose Vitamin C amid the Covid madness. High dose vitamin C, high carnivore-based Keto, and low ceruloplasmin primed me for iron overload. Taking Vitamin C with food increases iron levels. My Iron saturation was 29%, so it was fine. My...

And if you're forced to eat pork or chicken fed a high PUFA diet, it's best to eat the lean cuts. But the fattier cuts and the skin are the best parts of those animals. It's a tragedy.

I realize this wasn't directed at me, but my understanding is that that fat in avocados is mostly monounsaturated fat, with about 10% polyunsaturated fat. In a person who hasn't eaten a heavy PUFA diet, it would be fine. It's on par with olive oil. If a person is looking to lower PUFA stores...

On Bezos, we know he is on Testosterone Optimization Therapy of some kind. So he has some insight into the unfortunate reality of modern living immersed in endocrine disrupting hormones.

You don't think there is a political, climate-based initiative to get people to eat a plant-based diet? That seems like sophistry to me. A person can't consume any mainstream news without being inundated with propaganda about the dangers of eating animals. Here's an example of the propaganda...

Gman86, I think you know where I stand on this. Yes, IMO avoid all fish oil supplements. But not all seafood. Shrimp, crab, lobster, clams, oysters, squid, mussels and other shellfish are low PUFA. They are fine. I do believe cold-weather fatty fish (high in Omega 3s) should be avoided. Cod...

Episode 107

Episode 106

I hear you. If your triglycerides are low and HbA1c is low, you're doing lots of things right, which is most important. Of course there could be confounders involved. That said, the video is really one of three, and it's a fairly deep dive. Certainly the anti-Omega 3 and 6 view is by far a...

I don't intend to push my views on anyone, but I am now in the camp that there are no benefits to consuming Omega 3s or Omega 6s at all, whether in fish or fish oil supplements. For more on that view, I can suggest three episodes from Jay Feldman's Energy Balance podcast, starting at Ep. 105.

If you haven't already you should get genetic testing and run the results through NutraHacker and Prometheas. At this stage, i would suggest you consider going for whole genome sequencing. Prices are under $500. We're entering a revolution for whole genome testing and it's taking about 10-12...

Agree. I stopped supplementing zinc a long time ago, except as with an acute viral infection maybe once a year. My zinc levels are consistently within normal range, with copper and ceruloplasmin being low, as in very low normal or out of range low. Of course that is serum concentration vs...

@Cado, you are an interesting guy. Clearly knowledgeable. I realize blood serum copper levels don't speak to tissue saturations. But what about low serum copper levels combined with low ceruloplasmin levels? I ask because that's my situation. And full gene sequencing reveals I am...

I was a long time user of Metoprolol Succinate in the 100 to 150 mg range. Metoprolol is a cardioselective beta blocker, so it is definitely a positive for those concerned about more systemic effects (relaxing of the smooth muscle, causing breathing difficulties in those who have asthma or...

Research regarding the connection between NO and Autism Spectrum Disorder (in mice): Summary Article: https://www.advancedsciencenews.com/scientists-identify-a-new-molecular-mechanism-for-autism/ Full Study: https://onlinelibrary.wiley.com/doi/10.1002/advs.202205783

You just abstracted the abstract! Even shorter.