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I don’t have the side effects I was experiencing with the injectable. This, as soon as I take it, it really feels calming and soon after when I go to bed I really lay down very still in bed, it is the first Pro I’m using that help me to get to sleep. Some good and bad side effects during the...

I don’t think so. Prog in vitamin E, especially when applied to the gums, will bypass first pass in the liver, like an injection. Pro itself has a very short half life in the blood though, but I heard Georgi Dinkov and Mercola saying that because Vit E has about 44hr half life, Pro when...

Quick update on the Progesterone dissolved in Vitamin E trial. two weeks after applying a drop (3mg) on my gums, it did not raise my Progesterone serum. However, I do feel it.

@Jim Marlowe have you ever tried the StressNon from Idealabs, the Pregnenolone dissolved in DMSO?

and here Cataceous comes as usual with some unbiased, fair and articulate comment backed up with actual science, I much appreciate you. To add to your comment, even while on ketosis, the brain and some other tissues, still require some glucose. In fact, I would think ketones as brain glucose...

it sounds like you have some solid biology here to argue with Ray Peat, too bad he is not longer with us.

What were the vitamin E dosages you recall he was recommending? As far as thyroid, I don’t think he ever recommended high doses of thyroid hormone. He based his thyroid work on Broda Barnes, who would pay attention to body temperature, heart rate and paid attention to TSH, which I do not think...

O I found in his work some "little personal discoveries" I found by digging in the medical literature my self, even before even stumbling into his work. It made me to connect some dots about health, that Peat put together many years ago already. Example of his work the importance of burning...

I have been doing the same since Monday, after about 30/45min I feel super relaxed. Some people also put the drops on the tongue then massage into the gums. I’m starting to think this is really the best way to get Progesterone in, I’ll do some labs in a week or so

I saw this video before. If I had learned about Ray Peat earlier, I would have probably saved allot of time. But when years ago I was exposed to his work, I thought he was a lunatic!

@Jim Marlowe how do you apply your drop of Progesterone on the gums? do you use just a finger and massage it in?

One day I swear I will read all.

currently comparing these two products: https://healthnatura.com/simply-progesterone-1-08-oz/ https://shop.forefronthealth.com/collections/all/products/molecular-progesterone-supplement

@Jim Marlowe have you ever checked Progesterone levels while on the 3mg applied to the gums?

Did you take this in the am or before bed?

Thanks for attaching this paper, good read. The only thing I may not agree with Mercola is the dosing for males, 25/30mg in a delivery method that by pass the liver is wow. Probably 1-3mg daily for a men would be more physiological, unless Pro is used pharmacologically short term. It took me...

this is true, in fact Progesterone can lower ACTH, which I would think Pro would more like reduce the stress response. However, Pro can also feed the pathways and increase cortisol. Individual variations, and possibly the mechanism is dose dependent as well, with little Pro "helping" to produce...

it just doesn't feel right, it feels like years ago when my E2 was uncontrolled, minus the erection quality benefit, plus feeling wired and like I'm on something. Just the opposite of what Pro is suppose to do, and the opposite of Pro is Estrogen, which is excitatory. I have switched to IM...

that is a good point, hypothyroidism people can have same issue with Progesterone

that is so interesting, I just increased the dose since Thursday from 1mg to 1,5mg and switched to abdomen, and I feel crazy again, erections and wild sex thoughts, I would say overly exited and feeling wired, which is just the opposite of Progesterone. I just think I may not doing well...

@FunkOdyssey where did you inject your Pro, and for how long you did you try it? It is interesting comparing my response to yours, typically you would expect your response from Pro. Was your Pro suspended in sesame oil as well?

I have been reading for the past several months the work of Ray Peat. He studied Progesterone and Estrogen extensively since the 70"s I believe. He understood the importance of Progesterone, and figured out that the best route of administration is micronized Pro dissolved in Vitamin E...

Hi Vince, I have been using the injectable since November. I'm sure it is not placebo, the benefits and sides are noticeable and dose dependent

Progesterone scrotal

thanks. I started to think about this possibility when I was reading an article that compared SC vs Transdermal administration of DHEA, with SC increasing more estrogens. I'm going to try to change injection site and check levels again, see if I get a better response from it in an area with...

I haven't, thanks for suggesting this.

thanks for reading and replying. I can live with more body hair growth, but not feeling overly emotional. When I was on the scrotal cream, I didn't experience these side effects, and Pro level rose to top of the range, so probably discarding the sensitizing effect of Pro to estrogen receptor...

@Cataceous @Gman86 @JA Battle I would like to know your opinion on this I noticed that when I was on the 1,5mg or even worse at 2.5mg dose of Progesterone SC, I would experience some side effects such as being emotional, and way too much on the 2.5mg, and also more body hair growth, crazy...

my doc suggested to move the injection from night to am since I was having some sleep issues, I thought at the beginning it helped with that, but I'm actually don't think it was the issue. I want to try to move it at night again, since I find doing the injection at that time is more convenient...

1mg daily SC in the AM

@FunkOdyssey @Gman86 Have you guys seen a noticeable difference in labs going from Empower CYP to Hikma Enanthate?