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If you had to guess, do you think enclomiphene treatment would increase the amount of aromatase? During my 5 months of enclomiphene for fertility, I gained 25lbs of fat that I'm having trouble losing. I wasn't sure if it was the enclomiphene, or the fact that I had low testosterone levels for...

How quickly does aromatization occur? The reason I ask is, lately I've been feeling worse sexually (low libido, ed, dick turtling, etc) the day after my injection. Can aromatization occur this quickly? Or is that I'm throwing off my test/E2 ratio? I've been told by my clinic that estrogen...

Which of these gave you the best resolution of the fatigue, in your opinion? The one thing TRT has never done for me is resolve fatigue issues. I recently experimented with T3 (cytomel) for higher Reverse T3, but it did nothing for me. I did not experience increased energy, nor any fat loss...

If you're still on enclomiphene, stick with it. My fertility Dr told me it would take 12 weeks to see results. He said it takes 12 weeks for a complete sperm cycle. I was impatient and got tested at 11 weeks, and my sperm count was really high. Unfortunately, enclo wasn't able to boost my...

I'm just starting back on 200mg/week (100mg 2x/week) with hcg. I started TRT at this dosage (Dr supervised), and I guess ignorance was bliss because I have way more issues now that I started trying to tweak things. I'll keep you posted in a few weeks. In the last year I've tried drastically...

I'll have to dig to find the tests from a few years ago, however I just noticed that even a week after a smaller (50mg) injection, my levels were still elevated. Of course they were lower than peak, but not as low as I would expect having a lower shbg (16). My trough is definitely lower, just...

I have low shbg, and my exogenous testosterone seems to stick around a while in my serum blood tests. I don't know if it's a difference between what's happening in the cells vs in the serum, for low shbg guys? I've also read that shbg is also the transport means for testosterone, so with less...

Have you noticed fat loss, or just total weight loss (i.e. some muscle loss as well)? I'm curious because my Doc will write the script. I've read one of the ways it aids weight loss is via appetite suppressant. I would love to/need to lose a few pounds of fat, but already have a low appetite...

I just went through this, so I can tell you what I did, however I'm 46 and have been on TRT for 8 years. I wish I did a fertility test at the beginning, because that would've determined if I stayed on TRT plus HCG, or switch to Clomiphene or Enclomiphene. After 8 years on TRT and HCG, I...

@JimGainz and @Gman86 When you do (or have done) every day dosing, are you injecting subq, or IM? I'm a low shbg guy, and considering doing the same, but 365 IM injections a year sounds rough.

Very frustrating. I've heard someone else refer to it feeling like injecting water, which sounds about right. I've also read opinions that low shbg guys possibly "hyper metabolize", or "burn" though their TRT quickly which is why they suggest more frequent dosing. However, even after a week...

My creatinine has been high and eGFR has been low for several years. My doctor said that it was from eating a lot of protein and having more muscle mass/muscle metabolism, and he said I shouldn't be concerned. But now I'm seriously second guessing his opinion. Are there supplements for aiding...

@ERO Have you found anything that works for you yet? I found it interesting what Dr Mariano states, from @Okian post above: He states that high shbg guys need lower doses of testosterone, because SHBG prolongs testosterone's action. Would this imply low SHBG guys actually need higher doses...

@MIP1950 Any luck with the L-Histidine?

Did you ever try adding the clomid to your TRT? I have low shbg as well, so I was just curious.

My endo discussed possibly prescribing semaglutide, but I've read that there is a risk of thyroid tumors and/or thyroid cancer. I know you said you considered if very safe, so I was wondering if you have any insight on this?

Do you know the dosages/frequency RMC uses of Gonadorelin? Also, how much is too much, as I've heard it can have the opposite effect in very high dosages? I could be wrong on that though. I believe you use 20mcg of gonadorelin 5x/day, with 12.5mg of enclomiphene per day, along with your TRT...

Yeah, I mentioned above somewhere that my clinic first prescribed 200mg in one weekly dose, and I definitely seemed better on it. However, my hematocrit and hemoglobin were always high. That huge dose may have overcome any other issues...who knows? Now that I'm older, and supposedly wiser, I'm...

I too had some recent weight gain, brain fog, terrible libido, etc, so I had my thyroid labs done. All the numbers looked good, and close to optimal, except for my reverse T3, which was slightly higher than the top range. This could be due to stress, inflammation, or poor thyroid function. My...

Both were way better than they are now. I was also taking anastrozole sporadically, as I could never remember to take it on a schedule. Now I'm taking 100mg per week (50mg Mon/50mg Thur), 250iu HCG 2X/week, and I'm trying both approaches of taking minimal ai and no ai.

Haha, so true! Low shbg seems to make things very complicated. Before I knew any better, when I started TRT 8 years ago, I was prescribed 200mg once per week, with hcg, and anastrozole as needed. I definitely felt better than I do now, but had high rbc/hematocrit. Now I'm trying to do the...

Interesting! Have you found anything that works for you? I think options for me to try could include exogenous E2, as you suggested. Or increasing my TRT dose, or adding low dose nandrolone.

If this is true, then someone with low shbg would show symptoms of Low E2 (since dht opposes E2), rather than high free E2 as many others have suggested? Since the Test only dose (without ai) doesn't work for me, the only way to truly know for myself would be to try my typical TRT dose with...

I'd like to know the same, if anyone can answer. I know I've read (possibly a theory) that low shbg reduces androgen action without reducing estrogen action...meaning a skewed higher estrogen to testosterone ratio. I've also read (possible theory) that shbg transports the androgens, and if it's...

@Cataceous, would this possibly mean that low shbg guys would either need higher T levels, or lower estradiol levels than we previously thought? To make up for the skewed E/T ratio? I've been told that lower shbg guys need lower doses, more frequently, due to the higher free hormone levels...

@Guided_by_Voices That's great info, thank you!

@grayiron Have you experienced any noticeable effects, good or bad?

Thanks Guided_by_Voices! I'm glad the lab rat is doing well...hahaha. I'll definitely check out the aging matters blog! My TRT clinic PA said the exact same thing regarding hgh. They stated that at low dosages, all the negatives I was concerned with shouldn't be a problem. However, I take...

It seems like it's quality of life over quantity of life...and apparently everything has a negative. I didn't know rapamycin could possibly kickstart tumors? I also didn't know simply inhibiting mtor sacrificed quality of life, but I'm also no scientist. Have you/do you take any of the above?

I agree, as it seems like everything has its downside. I have tried a brief trial of HGH via my TRT clinic, and it definitely worked well. In just 3 months of a minimal dosage, I noticed reduced wrinkles, fat loss, better mood and outlook...but the idea of enlarged organs, cost, possible...

Hello All, I know Rapamycin has been mentioned in other threads, but I haven't read any threads with personal experiences. Is this still being considered as an anti-aging drug? From what I understand, the best options available for anti-aging are Rapamycin, HGH, Metformin, or Peptides (in...