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  1. Reason

    Recent labs: HIGH Estradiol. Causing sleep issues?

    I will discuss this in my consult. I am 37 and although I know HCG doesn't totally preserve fertility on TRT, I like the insurance.
  2. Reason

    Recent labs: HIGH Estradiol. Causing sleep issues?

    Are you saying that the sleep symptoms are not T or E2 related? The posts you shared have seemingly every single possible symptom low-t, most of which I do not have anymore since treatment, and therefore I'm not sure I've gained much from reading them.
  3. Reason

    Recent labs: HIGH Estradiol. Causing sleep issues?

    Only 5mg/day. Defy originally prescribed 15mg with 15mg Pregnenolone but I decided to stop for a few weeks to eliminate them as cause of the sleep issues. Nothing changed, so I'm re-introducing DHEA first, 5mg at a time, and wanted to try the Preg after.
  4. Reason

    Recent labs: HIGH Estradiol. Causing sleep issues?

    If it helps at all, my pre-TRT numbers: Total T: 366 ng/dL (264-916) Free T: 7.5 pg/mL (8.7-25.1) E2, sensitive: 16 pg/mL (8-35) SHBG: 34.3 nmol/L (16.5-55.9)
  5. Reason

    Recent labs: HIGH Estradiol. Causing sleep issues?

    I forgot to add it! SHBG included in the OP now.
  6. Reason

    Recent labs: HIGH Estradiol. Causing sleep issues?

    These are labs from mid Week 7: Total T: 957 ng/dL (264-916 range) Free T: 25.6 pg/mL (8.7-25.1) E2 Sensitive: 60.6 pg/mL (8.0-35.0) SHBG: 27.1 nmol/L (16.5-55.9) This is really high, right? I've also ordered a complete follow-up panel but because of Defy's scheduling quirks, I had to wait...
  7. Reason

    Upcoming Defy appt - feeling tired

    Sounds totally reasonable. I am on TRT because I tried everything else for most of my life and nothing made a big enough difference. I'm also 37 years old. Keto was magical for me for about 6 months and then things got worse again. I still want to go back on it for a few months of the year...
  8. Reason

    Blackhawk's journey with TRT

    Good luck, Blackhawk. I'd strongly consider taking a look at the metabolic theory of cancer if you're concerned. There's a great book on it and the history of cancer research by Travis Christofferson called "Tripping Over the Truth" and quite interesting new papers on the topic if you do a...
  9. Reason

    Upcoming Defy appt - feeling tired

    Looks like you're not getting enough sleep. But sleep quality (as opposed to quantity) could be a bigger factor. You say you struggle when your alarm goes off. Your usual 7-7.5hrs could be enough, but that's only if they're quality hours. On weekends (or whenever you can sleep in), how do you...
  10. Reason

    Article: How to Increase Muscle Pump /Strength at the Gym

    I wanted to add this article by Menno Hanselmanns to this discussion. https://bayesianbodybuilding.com/optimal-program-design/ Pump does not equal gains in size or strength. If you’re chasing the pump because it feels good, by all means. Otherwise, stop worrying.
  11. Reason

    Started my journey. Thank you.

    Week 6 Update: No major changes to report: mood/energy/libido still good. Doing really well even with lots of work-related stress. Sleep is a bit better, but not great. I'm injecting SubQ exclusively. Injection sites with shallow IM get VERY sore for a couple days. I've come to really...
  12. Reason

    Started my journey. Thank you.

    Defy does not request follow-up labs until 3 months into treatment. Should I get my own after 6 weeks (in a week or so)?
  13. Reason

    Started my journey. Thank you.

    Thanks for the replies, everyone. Apologies for not updating this thread on week 4, very busy at work. Week 4-5 Update: TL;DR: Feeling very good (when I sleep OK), best I've felt since starting treatment. Libido great. Starting to notice body composition changes in response to diet/exercise...
  14. Reason

    Insomnia on TRT

    Same here. Not finding much help and not sure what else to do.
  15. Reason

    Started my journey. Thank you.

    My insomnia is starting to take a toll on me. I'm not sure if the treatment has exacerbated the issue or not. I've been through worse, but 2+ months of bad sleep is rough on the mind and body... I've been combing through the forum and other reference material and it seems like TRT often...
  16. Reason

    Newbie protocol.

    Happy for you. Keep us posted. I also got a bit freaked out by the bubbles but don't care anymore. With the gym stuff, find a solid strength program like 5x5 or Starting Strength and stay consistent. I wasted a lot of time with broscience programs that had me doing a trillion isolation...
  17. Reason

    Started my journey. Thank you.

    Week 3 Update: TL;DR: Still feel good, little change from last week. Sleep still an issue. The Good: Mood still vastly improved from pre-TRT. That feeling of patience and optimism is the biggest change brought on by the treatment so far, and week after week it has been there for me. It sounds...
  18. Reason

    Different slant on why you wake up @ 0300 wide awake

    I’m very very skeptical of an influx of liquid fructose and glucose having any benefits at all to glycogen regulation, unless the addition of cream of tartar does some magic I’m not aware of. I’m going through this issue right now as well and I do wake up wired, I can almost feel the cortisol...
  19. Reason

    Started my journey. Thank you.

    Week 2 Update: TL;DR: Feeling really good. Noticeable improvements slowed down a bit. Still struggling with staying asleep. The Good: Symptom relief from week 1 are still here: better mood, more energy, just happier and generally more "alive." Feeling great the last couple days (start of...
  20. Reason

    E3.5D vs M W F injections

    This makes sense from a mathematical standpoint, but I wonder if it makes sense physiologically? Our natural T is supposed to peak in the morning, so wouldn't it make sense to follow this natural biorhythm? I'm new to this and trying to learn. I just started MWF and I'm injecting in the...
  21. Reason

    First injection 2 hours ago now I feel lightheaded?

    Yes. But I’m not needlephobic. I’ve been looking forward to injection day but since this is new there could be mixed adrenaline and anxiety that I’m perceiving as excitement. However, the lightheadedness kicks in right after injection, it builds like a slow wave.
  22. Reason

    Started my journey. Thank you.

    Thank you, Dr. Saya. I’ll try it in the morning.
  23. Reason

    First injection 2 hours ago now I feel lightheaded?

    I've just started this, only injected 4 times, 50mg Test-Cyp, but also feel a bit lightheaded every time. 25g, 5/8", tried 3 sites: belly fat, shoulder, quads. Same results, lightheadedness lasts a couple hours.
  24. Reason

    Started my journey. Thank you.

    I know this is early for most positive and potential side-effects, but I thought I'd log these weekly in case it is helpful to others. Just to recap, I'm injecting 50mg T and 300IU HCG MWF. 25mg Pregnenolone/DHEA nightly. TL;DR: After 1 week, I've felt a clear improvement in overall energy and...
  25. Reason

    My journey with TRT

    I'm 37, had a very similar experience and just started my own journey (yesterday, in fact). Also spoke with Melissa and my protocol is identical to yours. Keep us updated, and good luck to both of us!
  26. Reason

    Started my journey. Thank you.

    Started my TRT journey yesterday. After spending most of my life in a rut, hitting a wall every time I tried to get better, I decided to take the plunge. I'm 37 and never thought I'd have to be on hormone replacement therapy at this young age. But here I am and I'm very excited for the future...
  27. Reason

    Guidance with Initial Labs (very low Free-T)

    Thank you, I hope you're right. :)
  28. Reason

    Guidance with Initial Labs (very low Free-T)

    No, not one of the tests in the Defy initial battery.
  29. Reason

    Guidance with Initial Labs (very low Free-T)

    I was VERY happy to get rid of it. I was never very overweight so there was no hiding the gyno. None of my doctors ever mentioned there could be a possible non-random non-genetic cause worth looking into. Puberty was late but I was active and healthy. Never an athlete and scrawny but nothing...
  30. Reason

    Guidance with Initial Labs (very low Free-T)

    @Vince: You're right, but I am looking to get better informed before my consultation, so besides reading all the info here, I was wondering if your (EM's members') trained eyes could spot something besides the low test I could look into. Not necessarily recommend care, which is why I sought...
  31. Reason

    Guidance with Initial Labs (very low Free-T)

    I'm wondering why I've received no replies yet. Did I make a mistake I'm not aware of?
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