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This sounds a lot like the honeymoon period I had with propionate. It lasted a week or two. I had a similar experience with bremelanotide, though shorter. It will be interesting to see if your results are sustained for a longer period.

https://www.excelmale.com/threads/a-different-dosing-strategy-with-bremelanotide-pt-141-yields-dramatically-better-results.28542/

Making it seem even more likely to be a lab error or some dosing issue instead of a 50% increase in free testosterone caused by a very large change in liver metabolism.

Some of us have found this to be the case. When I dose such that testosterone is highish or rises early in the night, sleep quality and duration are degraded. Switching to—early morning—injections of the aforementioned TE/TP blend resolved the issue, giving me an extra hour of quality sleep, on...

With a longer ester such as cypionate, you can't come very close to a natural pattern of testosterone levels, regardless. With frequent injections, levels are almost flat, having minimal variation. With infrequent injections, there are relatively large variations taking place over days. In...

Contrary to popular perception, this is a mid-level dose, providing more testosterone than most healthy young men make naturally. Therefore it could easily be too much testosterone for your physiology. The low SHBG and high free testosterone are suggestive of excess. Ask yourself whether it...

That clause has to mean that you wouldn't simultaneously receive TRT from elsewhere. It would be extremely unreasonable to deny you other avenues of treatment. But in the worst case you would need to find a new PCP, which would surely nullify the agreement. However, I'm no lawyer, so if you want...

Testosterone overdose. E2/T ratio on the low side.

Here's one study for starters. You can also follow the references. In this case the dose range was 3-15 mcg every 90 minutes. Results compared favorably to hCG/hMG therapy.

Of course delivering GnRH (gonadorelin) in pulsatile fashion via pump is already an approved treatment option for hypogonadism. I'm not sure if kisspeptin delivery needs to be pulsatile as well. If so then it seems likely that the frequency should correspond to that of GnRH. One study found that...

I assume you mean to say you have secondary hypogonadism, which applies when there's dysfunction at the hypothalamus or pituitary. Primary refers to testicular dysfunction. If your problem is with the pituitary then kisspeptin or gonadorelin wouldn't be of much use. However, hypothalamic...

I see essentially no change in cFTV based on averages, using 4.3 g/dL for albumin. Order: Baseline -> KD SHBG: 25.0 -> 31.2 nMol/L TT: 18.2 -> 20.2 nMol/L cFTV: 0.449 -> 0.452 nMol/L FAI: 72.8 -> 64.7 Using FAI as a proxy for free testosterone seems like a poor choice in 2024.

You're probably operating under a misconception. Research so far supports the proposition that testosterone esters, e.g. testosterone cypionate, are essentially inert until they reach the bloodstream. Only there do they make contact with enzymes that cleave the testosterone from the ester to...

Thus far, testosterone nasal gel, e.g. Natesto, is the only form of exogenous testosterone proven to allow continued natural production and retention of fertility. There's speculation that buccally-applied testosterone may yield similar results.

Hardly. Too much time playing Wordscapes. I think "altodare" has a nice ring to it.

"oraldate" if you want to be a little risqué.

Hope it goes well and they let you go home tomorrow...

Clever. Still some left for next time, though hope you stay put instead. "tealroad", or maybe "roadtale"? Is "oatalder" against the rules?

When challenged, he either disappears or else ignores it. Credit to you for providing the references.

I agree with @BadassBlues and @Seagal. Commenters shouldn't be suggesting low free testosterone when they don't even bother to estimate it. With default albumin, your Vermeulen calculated free testosterone is 13.5 ng/dL. This is a robust midrange figure, which makes it unlikely that a lack of...

I don't know for sure, but this work says there are about four times as many Sertoli cells as Leydig cells. If the cellular volumes are similar then it would imply that Sertoli cells are the bigger contributor to total volume.

In controlled studies, no differences have been observed in total absorption. That is, total areas under the serum level response curves are similar for IM and SC. However, the response curves may have different shapes that vary with the delivery method, and also between individuals. In...

At least take a moment to read about Sertoli cells and Leydig cells so your posts on the subject have some redeeming value. You'll find that Sertoli cells respond to FSH, while Leydig cells respond to LH and hCG, which is presumably what Dr. Saya was alluding to. TRT-induced testicular atrophy...

Lately it's around the waist, 400 mcg/day.

Another nice find by @ajax31. GDF11 is attracting interest in the anti-aging community. Now it looks like it's a possible treatment for arthritis. Like FGF18, this is a protein rather than a peptide. Because of the anti-aging market, GDF11 is more accessible than FGF18. GDF11 protects against...

I'm not convinced by this explanation, though that leaves open the question of why your serum progesterone levels aren't higher. There's a two-step process to get to androstenedione, requiring a couple of enzymes. This is also described as a secondary pathway, with the primary being from DHEA...

Yes, this substitution is ok. The cypionate and enanthate testosterone esters are pretty much interchangeable; they have similar half-lives and similar fractions of testosterone by weight. If by "double strength" you are referring to the concentration in mg/mL then you are correct in planning to...

No side effects, everything is topical.

I use those topically (50 mg minoxidil, 0.2 mg finasteride) along with dutasteride (0.2 mg) and cetirizine (10 mg). No regrowth, but the rate of loss has become imperceptible.

I view it as malpractice to start someone on such a large dose of testosterone. This is not TRT. Replacement amounts would consist of 40-100 mg of testosterone cypionate per week in divided doses. Many guys do not fare well with such excess...

31 gauge, 5/16", subcutaneous, mostly around the waist.