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https://unrealsupps.co.uk/iconic-formulations/dermacrine/?srsltid=AfmBOooGfJ6heKOuFm2tAbA2C0bi_BGbnsserUOAiW3IvGEx-KXYMnvH Got dhea & pregnenolone in it, although i can't find out exactly how much. Also, not cheap. I've been debating getting some myself, but i'm not sure i want to spend that...

Just wondering if anyone on the forum has experience with topical androsterone? I'm looking at buying a product (Alpha Gains 1-Andro TD) that contains 100mg of androsterone per ml. I'm looking to try it for its purported mental benefits. Wikipedia claims androsterone acts as a PAM of the GABAA...

Update - since stopping the ipamorelin / mod grf injections, the swelling and itching in my toes has gone. Obviously not a suitable treatment for me.

Rather than start a new thread, i thought i'd put this here. I bought some ipamorelin and modified grf (1-29) just before Christmas, and have been injecting 100mcg of each once a day, monday to friday. Over the last couple of weeks though, i've been getting red, swollen toes. This seems to start...

https://chrismasterjohnphd.substack.com/p/the-ultimate-vitamin-k2-resource

I'm currently taking 12.5mg a day. The ones i have are 25mg tablets, and i just bite half off in the morning when i get up. I hold it under my tongue for a while and let it disolve before swallowing. I don't know where doing this puts my dhea-s levels as it's not included on the Medichecks...

@nippy Just looking at one of your older posts, you mentioned you've always had low e2 - "My last E2 result was march 23 and it was 57 pmol. Thats with me pinning so shows my E2 is always low . Don't know how I can boost my E2... If my blood comes back and my free t is low I'm going back on...

Lol, maybe. Have you ever tried tongkat ali? Just my personal experience here, but i find it significantly increases my libido (unfortunately for me though, it also seems to cause the rheumatism in my thumb joints to flare up so i've had to stop taking it) It's also supposed to lower shbg if...

I was showing that what you hoped you'd get by adjusting shbg in a free t calculator would give you the increase in free t number you were after. And that although in reality it's more complicated than that, it's one reason why people claim lowering shbg gives increased free t. That was all...

I dunno, for fun?

Hmm. If you take that free t calculator, put your numbers in but half the shbg, the free t value goes up, so......

Interesting interview on Dr Eric Berg's youtube channel with top vitamin D researcher Professor Bruce Hollis (spoiler alert, he takes 10,000iu vitd3 a day)

Does that help with RA?

Both files come back "page not found"?

FWIW, and to give a counter view, i take 5 grams of high strength fish oil a day (total 2,750mg combined EPA & DHA), and my libido is very high.

Any chance you could go into a bit more detail regarding how you modified the PSMF diet?

Nizoral (ketoconazole) shampoo might be worth looking into too. I've used it for years, originally due to scalp psoriasis i had as a kid, but later after reading how people were using it to try and prevent hair loss. All i can say is, i have two brothers - both have lost most of their hair...

Fwiw, i currently do 84mg/week, spread across two injections per week (42mg Sun AM, 42mg Wed PM). I don't use a clinic by the way. My last blood test, taken at a trough, so just before an injection came back at: Total T - 25.4nmol/l (732ng/dl) Free T - 0.517nmol/l (14.9ng/dl). So it was a...

Just my opinion as i have years of experience with both - kratom and modafinil. Obviously, see what your blood work shows first, but kratom (in my opinion) is a great mood booster, and modafinil (in my opinion) will wake you up without feeling jittery like too much caffeine can.

Not long back home from hip op #2, right hip (and already started back on the DHEA). I'd forgotten how stressful it felt being out of theatre and on the ward. I was there two nights, and you get no chance to sleep as you're woken every two hours to take blood pressure, oxygen saturation and...

Had a letter arrive in the post late yesterday - got the date for my other hip to be done. That means it'll be 10 weeks between surgeries, and not the 6 months i was originally told by the surgeon that i'd need to recover. I'm not sure if this is because he thinks i've recovered quickly like...

Me, left hip replacement in August. Getting the other one done in 3 weeks - i was originally told time between ops would be 4 to 6 months, but this will be 10 weeks.

'Self experimentation', yes, i've done a fair amount of that myself over the years too, lol. And i agree with you regarding the sun being a superior way to get your vit d (and according to Jack Kruse who i follow on IG, many other benefits too - i just wish i understood what the hell he's on...

Wow, 50k iu a day! What were your reasons for such a high dose, were you trying to resolve an autoimmune type issue? I have been tempted recently to increase my own to 30k iu, just to see what, if any, effect it has on my rheumatic thumb joint. But i'd want to do blood work to see where it puts...

Interesting, they sell allopregnanolone nasal spray too. https://russianstarpeptides.com/product/allopregnanolone-5mg-nasal-spray/

That's a fairly low dose to reach that level (and i'm assuming you meant ng/ml, not dl). I guess that's why blood work's always important - individual variation, plus, there's always the issue of supplement stated dosage accuracy, unless it's pharma grade.

Another vit D safety study from 2015 by Dr Michael Holick. https://www.mayoclinicproceedings.org/article/S0025-6196(15)00244-X/fulltext "The evidence is clear that vitamin D toxicity is one of the rarest medical conditions and is typically due to intentional or inadvertent intake of extremely...

As a follow on from above - it's apparently important when taking vitamin d3, especially higher dosages, to also take additional vitamin A, vitamin K2, and magnesium. The vit A increases vit d's effectiveness, and vit K2 directs calcium the right way.

I reckon i need to up my dose then. For years i took 5000 iu / day, but recently (month or so before hip hip replacement) i increased that to 10,000 iu. My last blood test on 5000 iu (and i was sunbathing too, but keep in mind i live in the UK) was 92 nmol/l (37ng/ml). I've read a lot about how...

Above link only showed the abstract, full version below - https://www.researchsquare.com/article/rs-4202165/v1

In mice, and not peer reviewed yet, but very interesting. https://pubmed.ncbi.nlm.nih.gov/38766160/