EMPOWER PHARMACY - Personalizing Testosterone Therapy: Exploring Oral Solutions (Kyzatrex)

madman · Apr 13, 2025

It was inevitable.....you knew this was coming LOL!

As always Nelson's house is where it's at!

Testosterone Undecanoate (Kyzatrex®) Capsules

Choose Empower Pharmacy for compounded Kyzatrex capsules. The leading accredited 503A and FDA-registered 503B compounding pharmacy.

www.empowerpharmacy.com

Go big or go home we say!

Kyzatrex Webinar with Dr. Mohit Khera [April 2025]

Join our free webinar on April 10 2025, at 6:30 PM CST with Dr. Mohit Khera board-certified urologist, as we explore testosterone therapy.

www.empowerpharmacy.com

Hosted by Dr. Mohit Khera, a board-certified urologist and leading expert in testosterone optimization.

Empower is thrilled to host a free educational webinar on KYZATREX®, an FDA-approved oral testosterone treatment designed for men with low testosterone. It’s been shown to be up to 96% effective in helping men restore testosterone to normal levels.1,2* This informative session will provide prescribers with key insights into this innovative treatment option and how it can benefit their patients.

In this engaging session, "Personalizing Testosterone Therapy: Exploring Oral Solutions" you’ll learn:

* The history and need for Testosterone Replacement Therapy (TRT)

* Benefits and clinical considerations of KYZATREX® as an oral testosterone replacement therapy.

Discover how Empower can support your practice by providing compounded, brand-name, and generic medications all-in-one place. Our nationwide shipping capabilities, ensuring seamless patient access across all 50 states.

madman · Apr 13, 2025

Thread 'KYZATREX (oral testosterone undecanoate) Updates'

Oct 16, 2022

KYZATREX™ (testosterone undecanoate capsules)

The Power of Hormonal Balance | Restore your T- levels with Two KYZATREX capsules a day. | Discover KYZATREX Rediscover CONFIDENCE | A solution sans needles, gels, or creams

www.kyzatrex.com

KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic hypogonadism 11 12. Here is detailed information regarding its dosage, usage, side effects, price, and efficacy:

Dosage

KYZATREX is available in capsule form in three dosage strengths: 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg...

Thread 'Oral Arguments: Getting the Word Out About Oral TRT'

Oct 11, 2024

Oral Arguments: Getting the Word Out About Oral TRT - Endocrine News

Injectable and gel versions of testosterone replacement therapy have long been considered cumbersome by both patients and providers, for a litany of reasons from being difficult to administer to an overwhelming insurance burden. However, research from ENDO 2024 revealed that a new oral therapy...

endocrinenews.endocrine.org

Injectable and gel versions of testosterone replacement therapy have long been considered cumbersome by both patients and providers, for a litany of reasons from being difficult to administer to an overwhelming insurance burden. However, research from ENDO 2024 revealed that a new oral therapy could potentially eliminate these barriers and be a safer option.

Although testosterone replacement therapy (TRT) has been around for decades, a recent survey jointly...

post #10 (Go nuts!)

Thread 'Oral Testosterone Therapy in Men with Low Testosterone: A Comprehensive Review'

Nov 17, 2024

Introduction

Background and significance

Hypogonadism, characterized by low testosterone levels, is a significant clinical condition affecting a substantial proportion of the male population, particularly older men. The management of hypogonadism often involves testosterone replacement therapy (TRT), which can be administered through various routes, including intramuscular injections, transdermal patches, and oral formulations. While injectable and transdermal options have been extensively studied, oral testosterone therapy, particularly using testosterone undecanoate (TU)...

madman · Apr 18, 2025

Thread 'Shifting the Testosterone Treatment Paradigm with Oral Testosterone (Kyzatrex)'

Apr 18, 2025

Again you heard it here first!

Nelson's domain the one and only!

Very informative webinar on the use of the newer oral TU formulations.

Testosterone therapy has long been dominated by injectable and topical formulations, but the landscape is evolving. This webinar explores how oral testosterone is redefining treatment protocols, offering a convenient and effective alternative. With recent clinical insights and real-world data, we’ll discuss why practitioners should reconsider their approach to testosterone replacement therapy (TRT)....

madman · Apr 18, 2025

7:55-13:42

Thread 'Oral TU (Kyzatrex) - Breakfast + Lunch Dosing Protocol/PKs'

Apr 18, 2025

* Just to be clear when it comes to the Breakfast + Lunch Dosing Protocol/PK as Dr. Sun stated: and although this is obviously not real pharmacokinetics I just basically superimposed the two graphs on eacth other and I think that this is roughly what's happening because I've checked labs on hundreds of patients at all different time frames

7:55-13:42

ignition · Apr 19, 2025

Note: I am not a noob, have a 9 year history here under a different username changed due to online security issues.

4 points:

1- Glad Empower is on board. After having to stop injections after 8 years because of erythrocytosis, I left Dr Saya last year because there was no good connection to fill a Kyzatrex script from him. He wrote it for Defy's standard fee, but I was not able to get it filled through the other mail order pharmacies that say they carry it. (Due to my comprehensive medical history, there was no way I'd go though Marius partners like vitamin shoppe.)

I had terrible trouble trying to get Kyzatrex until they listed a local Uro who did his fellowship with Lipshulz. Took months to get a script filled, but finally on Kyzatrex,

2- Glad to see they compiled the breakfast/lunch kinetic graph. I've had trouble with the peaks/troughs. I have taken that idea a step further, and evened things out a bit taking 200mg breakfast, 100mg lunch. It isn't part of their standard Rx plan to issue two different strength pills, but my uro supplies the Kyzatrex from their office which works out to the same cost as taking two of the same dose pills/day. Doing better on this plan so far.

3-My erythrocytosis is resolved, and I am happy enough, but not feeling as well as on a Cataceous type of Prop/Enanthate blend daily.

4-My trough is too low, and the morning dose of Kyzatrex has a strong stimulant effect, it is a daily roller coaster, but my veins are happier.

I think I would do better on three 100mg doses/day, but doesn't work well with feeding times and remembering to take that may doses a day. And the cost basis is per pill not the dose per pill, so it would cost 1/2 again as much.

madman · Apr 19, 2025

ignition said:
Note: I am not a noob, have a 9 year history here under a different username changed due to online security issues.

4 points:

1- Glad Empower is on board. After having to stop injections after 8 years because of erythrocytosis, I left Dr Saya last year because there was no good connection to fill a Kyzatrex script from him. He wrote it for Defy's standard fee, but I was not able to get it filled through the other mail order pharmacies that say they carry it. (Due to my comprehensive medical history, there was no way I'd go though Marius partners like vitamin shoppe.)

I had terrible trouble trying to get Kyzatrex until they listed a local Uro who did his fellowship with Lipshulz. Took months to get a script filled, but finally on Kyzatrex,

2- Glad to see they compiled the breakfast/lunch kinetic graph. I've had trouble with the peaks/troughs. I have taken that idea a step further, and evened things out a bit taking 200mg breakfast, 100mg lunch. It isn't part of their standard Rx plan to issue two different strength pills, but my uro supplies the Kyzatrex from their office which works out to the same cost as taking two of the same dose pills/day. Doing better on this plan so far.

3-My erythrocytosis is resolved, and I am happy enough, but not feeling as well as on a Cataceous type of Prop/Enanthate blend daily.

4-My trough is too low, and the morning dose of Kyzatrex has a strong stimulant effect, it is a daily roller coaster, but my veins are happier.

I think I would do better on three 100mg doses/day, but doesn't work well with feeding times and remembering to take that may doses a day. And the cost basis is per pill not the dose per pill, so it would cost 1/2 again as much.

BH I remember you!

Uro from where you reside?

Daniel J. Mazur, MD | Urology Associates | Denver, CO

Dr. Daniel Mazur is a Denver Metro urology doctor at Urology Associates. He specializes in male infertility, vasectomy reversal, erectile dysfunction, microscopic surgery, andrology & men’s sexual health, testosterone therapy, BPH (prostate enlargement), and stone disease.

www.denverurology.com

Yes the downfall here for some would be the daily swings in peak/trough let alone trough levels will always end up near/back to baseline which can have a negative impact on overall well-being.

Fine line here especially for those reaping the beneficial effects when it comes to preventing/minimizing elevated RBCs, hemoglobin and hematocrit which is a given when running too high a trough/steady-state FT level as any of the oral TU formulations (Jatenzom Tlando or Kyzaterx) will have the least impact on one of the most common side effect when using exogenous T.

Just to be clear when it comes to the Breakfast + Lunch Dosing Protocol/PK as Dr. Sun stated: and although this is obviously not real pharmacokinetics I just basically superimposed the two graphs on eacth other and I think that this is roughly what's happening because I've checked labs on hundreds of patients at all different time frames

madman · Apr 19, 2025

Thread 'CDC STANDARDIZED TOTAL T and ESTRADIOL ASSAYS and soon to be FREE TESTOSTERONE!'

Jan 5, 2019

How the CDC Clinical Standardization Programs Are Improving Hormone Tests - AACC.org

WHAT PROGRESS HAS CDC MADE WITH STANDARDIZING TOTAL TESTOSTERONE AND ESTRADIOL TESTS?

Since HoSt began in 2010, CDC has had more than 350 participants in 15 countries. Participants have shown measurable improvements for both total testosterone (TT) and estradiol (E2). Specifically, the among-laboratory bias has decreased from 16.5% in 2007 to 2.8% in 2017 for TT and from 54.8% in 2012 to 13.9% in 2017 for E2. Not only has bias improved, but data...

ignition · Apr 19, 2025

madman said:
Uro from where?

Abram McBride Colorado Springs

madman · Apr 20, 2025

Thread 'Dr. Mohit Khera - Personalizing Testosterone Therapy: Exploring Oral Solutions (Kyzatrex)'

Apr 20, 2025

Kyzatrex (oral TU)

* FDA approved cash only oral testosterone

madman · Apr 28, 2025

Thread 'Updates in testosterone therapy - Oral T combination Therapy'

Apr 28, 2025

* Sun explains how oral testosterone formulations—thanks to their short-acting pharmacokinetics—can preserve some endogenous testosterone production, unlike traditional injections that often completely suppress it.

* He details how he customizes treatment plans by blending oral testosterone with agents like Clomiphene to boost hormonal levels without fully shutting down the body's own system, offering a more physiologically balanced solution for men who may want children in the future.

* Later, they delve into combination therapy strategies, including using oral...

madman · May 9, 2025

Thread 'Oral Testosterone for All: Why Diet Alone Won’t Fix Your Health'

May 9, 2025

In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to break through the testosterone misinformation that’s kept millions suffering. They unpack the real causes of the global testosterone crisis—including endocrine disruptors, poor sleep, processed food, and outdated fears around steroids and toxic masculinity. You’ll learn why testosterone matters for both men and women, how it powers dopamine, mitochondrial health, sleep, libido, and mood—and why “natural” testosterone boost methods usually...

madman · Jun 25, 2025

Thread 'Rethinking Oral TRT with KYZATREX®'

Jun 25, 2025

Modern patients want simple, effective treatment options.

KYZATREX® offers oral testosterone therapy with proven efficacy—and none of the mess, pain, or liver strain of older options.

.Join Dr. John Mulhall for a deep dive into the science and patient selection for KYZATREX®.

John P. Mulhall (Andrologist/Urologist)

madman · Jul 10, 2025

Thread 'Oral Testosterone For Better Health'

Jul 10, 2025

Dr. Sun has treated over 1000 men with oral TU!

Most men do better 300-400 mg BID.

His breakfast/lunch dosing protocol is the most popular!

Curious about the real power of testosterone beyond the realm of bodybuilding? Join us as we sit down with Dr Andrew Sun, a fellowship-trained andrology specialist, who unpacks the diverse roles this crucial hormone plays in men's health. Discover the surprising factors, like poor sleep and metabolic syndrome, that can lower testosterone levels even in younger men. Andrew guides us through the significance of...

madman · Jul 18, 2025

Thread 'Reimagining Testosterone Therapy: KYZATREX® (Oral TU)'

Jul 18, 2025

* We discuss KYZATREX, a cutting-edge oral therapy that employs lymphatic absorption to preserve liver health and supports fertility, making it ideal for younger men. We also examine its ability to maintain hormone balance without the need for aromatase inhibitors

Shalin Shah is a distinguished leader in the field of metabolic health, specializing in testosterone replacement therapy. As the Chief Executive Officer of Marius Pharmaceuticals, he was instrumental in the development and FDA approval of KYZATREX® (testosterone undecanoate) CIII...

madman · Jul 24, 2025

Thread 'How Oral Pills Testosterone (TRT) Work, Link to TRT & Prostate Cancer'

Jul 24, 2025

In this episode, Dr. Geo sits down with renowned urologist and men’s health expert Dr. Mohit Khera—professor at Baylor College of Medicine with over 160 peer-reviewed publications—to unpack the facts, myths, and future of testosterone treatment. They cover oral options, including Kyzatrex, how to interpret labs like SHBG and estradiol, and why testosterone could actually be protective—not harmful—for prostate health.This episode is packed with clarity, not hype. If you or someone you love is navigating testosterone therapy or prostate cancer recovery...