Recent content by wannabefan

I seem to convert T to DHT. At mild-moderate doses of 100-150mg T cream/day, my DHT levels run around 200. T levels range from 650-800, E2 30, SHBG 30. I have no clinical signs or symptoms to the negative whatsoever. What is the short and long term impact of running such “high” DHT levels? HCt...

It sounds like you may actually need a metabolic workup and a complete insulin resistance challenge test, some monitoring, etc. before you tackle TRT.

Intermittent fasting and a CGM would help.

It’s unclear if at the time of your serum labs if you had washed out prior TRT. You have LH so I assume you were either “coming down” from TRT or had fully washed out prior use. DHEA is upstream Testosterone, and feeds T. You have shown the metabolite “S” of DHEA. I would want a fuller picture...

You appear to be supplementing with DHEA. You might stop. You might get a Pregnenolone lab. You might get a urine metabolite (DUTCH) test, and see if you are a responder/converter. You might get a DHT lab.

FWIW after 6 weeks of 200mg QD cream, HCt went from 46 to 50, and back down after stopping. It’s not the cypionate.

Not knowing your baseline levels isn't ideal, but it would appear something is off with lab values and I would have redrawn. A Hct of only 48 would indicate T isn't being pumped as much as they go hand in hand. I assume your LH is 0.

Wow you are a hyperresponder to DHT conversion pathway. What are your E2 levels, baseline and post-cream application as measured? What has happened to your SHBG levels? Assume your LH went to 0?

My SHBG dropped in half after 6 weeks of cream, then measured at 4 weeks off. All other labs mostly came back, except DHT, so I will test again in 6 weeks or so.

I felt good on T cream, 6 weeks (didn't feel bad really prior, just wanted to optimize). I am off now, 4 weeks+. My levels returned for most part, although DHT and SHBG are below baseline. T back to within 90% and LH back 100% (happy for that). I will consider going back on again. PSA stable...

The peer reviewed data I have read showed PK for nasal is 40m-60m peak concentration, don't recall half life. Typically anything that peaks that soon, clears the body more slowly. I don't have either primary or secondary, per se, albeit my baseline T is 375-500, Free T 2% and LH 4.1.

FWIW, my E2, 18, did not change whatsoever, DHT up 250%, SHBG dropped 20%, and now that I am off, it is at 45% of what it was pre-T, too low.

Scrotal levels peak at 5 hours according to a PK study done in 2017 (tested 50 mg and 2 lower doses but curve to trough is similar). If I split doses, 7A and 4P, was thinking that could work, perhaps 150mg, 2 clicks scrotal, 1 arm as DHT was 95 at 4 clicks. 3 clicks may also work and keep my...

200mg Cream QD in AM. To your point, it appears, at 50mg, peak levels are within 5 hours, and we begin to see troughing down to 16 hours as measured. https://onlinelibrary.wiley.com/doi/10.1111/andr.12357

https://pubmed.ncbi.nlm.nih.gov/28334510/ PK levels for T and DHT via scrotal cream delivery.