Recent content by Vestpocket

The reason is that GSK actually paid prominent hosts and writers to say that. It isn't true, at all. GSK was fined in 2012, very quietly, 3 billion dollars for the stunt. Those assertions were not backed up by any science.

It didn't work, at all, for me. I also tried D2 agonists. Wellbutrin (XL) appeared to produce a paradoxical reaction, causing extreme fatigue. (Patients with this response are told to take it at night.) Apomorphine does work, but it induces only the blood flow response via stimulating the...

This is not true. There are zero studies that show antidepressants to be "very effective." At best, there are studies that can show that there is a minimal, marginal effect, when given enough time. A 2018 metastudy showed that the average placebo match for all third generation ADs is 74%...

I hate to chime in on this, given that I respect many of the posters and knowledge they provide, but there is a great deal of misinformation presented here. This is misleading. If the thermostat clicks on when estrogen (E) is too low, then men with an androgen deficiency would, from...

Low levels of SHBG can exponentially increase the metabolic clearance rate of testosterone, but do not significantly affect the MCR of estradiol. This leads to a potential FE2:FT imbalance. However, the idea that men with low SHBG are on a rollercoaster is wrong. When we talk about daily...

The free hormone hypothesis is indeed a myth and based on very old studies with limited in vitro tissue samples. However, that's true for most hormone research. In men on TRT, low SHBG will increase free diffusion through cell membranes, but accelerate hepatic metabolic clearance and reduce...

Actually, it can be raised. A moderator at PeakT brought his SHBG up from 13 to 30 nmol/L via intensive diet and exercise. An insurance researcher from Reddit demonstrated labs where his SHBG went from 14 to 28 nmol/L. This dropped his E2 by over half, with the same T dose. Dr. Crisler...

I agree with the bulk of the original poster's post, but one thing is not true. With low SHBG, testosterone will NOT lower SHBG further. In fact, for higher doses of testosterone, due to excess estradiol, SHBG will usually go up 1-3 nmol/L from the baseline. In my case, it will start...

Yeah, that's what I'm talking about. Not only that, but if you test your DHT, you'll find that even with midrange DHT, your free DHT is out of range. With low SHBG, every free hormone will be out of range at normal bound values. I've been doing a little research, and there actually might be...

Will, The difference is that you're dealing with men with impaired livers in this thread. Both Vince Carter and Bonetti Gianluca have naturally low SHBG. They're going to have supraphysiological free testosterone levels no matter what. They are going to have supraphysiological estradiol and...

Right, but your T and E2 both increased. SHBG is supposed to increase along with other hormones. There's no way it would just stay the same. So, the effect is not necessarily from tamoxifen. SHBG would have increased no matter how you increased T/E2.

The problem with SERMs is that the current offerings (tamoxifen/clomiphene) only increase SHBG by up to 30% in studies. For a guy suffering with SHBG between 8-13 nmol/L, we're talking about a difference of a paltry +3 nmol/L. That's essentially irrelevant. The kind of increase we're looking...

I would mirror ERO's assertion. If you have genetically low SHBG: T3 will absolutely not increase it, clomid will absolutely not increase it, diet will absolutely not increase it and estrogen will absolutely not increase it. Nothing will increase it. Production is genetically limited. It's...

That sounds insane to me. 5-10 lbs. of muscle in a single year? Jesus. It would take me 5-10 years to build 5-10 lbs. of muscle. I once had a trainer tell me that we were going to lose an inch off of my waist (not even starting out large) per week. Man, I've never laughed so hard in my...

Calories and effort shouldn't make that much ofa difference in sustained workout progress. If you're young, slim and lift weights in any generally proper way, you should gain muscle. Men in prison with very less than ideal conditions gain muscle. High stress, low sleep, no control over diet...