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The reason is that GSK actually paid prominent hosts and writers to say that. It isn't true, at all. GSK was fined in 2012, very quietly, 3 billion dollars for the stunt. Those assertions were not backed up by any science.

It didn't work, at all, for me. I also tried D2 agonists. Wellbutrin (XL) appeared to produce a paradoxical reaction, causing extreme fatigue. (Patients with this response are told to take it at night.) Apomorphine does work, but it induces only the blood flow response via stimulating the...

This is not true. There are zero studies that show antidepressants to be "very effective." At best, there are studies that can show that there is a minimal, marginal effect, when given enough time. A 2018 metastudy showed that the average placebo match for all third generation ADs is 74%...

I hate to chime in on this, given that I respect many of the posters and knowledge they provide, but there is a great deal of misinformation presented here. This is misleading. If the thermostat clicks on when estrogen (E) is too low, then men with an androgen deficiency would, from...

Low levels of SHBG can exponentially increase the metabolic clearance rate of testosterone, but do not significantly affect the MCR of estradiol. This leads to a potential FE2:FT imbalance. However, the idea that men with low SHBG are on a rollercoaster is wrong. When we talk about daily...

The free hormone hypothesis is indeed a myth and based on very old studies with limited in vitro tissue samples. However, that's true for most hormone research. In men on TRT, low SHBG will increase free diffusion through cell membranes, but accelerate hepatic metabolic clearance and reduce...

Actually, it can be raised. A moderator at PeakT brought his SHBG up from 13 to 30 nmol/L via intensive diet and exercise. An insurance researcher from Reddit demonstrated labs where his SHBG went from 14 to 28 nmol/L. This dropped his E2 by over half, with the same T dose. Dr. Crisler...

I agree with the bulk of the original poster's post, but one thing is not true. With low SHBG, testosterone will NOT lower SHBG further. In fact, for higher doses of testosterone, due to excess estradiol, SHBG will usually go up 1-3 nmol/L from the baseline. In my case, it will start...

Yeah, that's what I'm talking about. Not only that, but if you test your DHT, you'll find that even with midrange DHT, your free DHT is out of range. With low SHBG, every free hormone will be out of range at normal bound values. I've been doing a little research, and there actually might be...

Will, The difference is that you're dealing with men with impaired livers in this thread. Both Vince Carter and Bonetti Gianluca have naturally low SHBG. They're going to have supraphysiological free testosterone levels no matter what. They are going to have supraphysiological estradiol and...

Right, but your T and E2 both increased. SHBG is supposed to increase along with other hormones. There's no way it would just stay the same. So, the effect is not necessarily from tamoxifen. SHBG would have increased no matter how you increased T/E2.

The problem with SERMs is that the current offerings (tamoxifen/clomiphene) only increase SHBG by up to 30% in studies. For a guy suffering with SHBG between 8-13 nmol/L, we're talking about a difference of a paltry +3 nmol/L. That's essentially irrelevant. The kind of increase we're looking...

I would mirror ERO's assertion. If you have genetically low SHBG: T3 will absolutely not increase it, clomid will absolutely not increase it, diet will absolutely not increase it and estrogen will absolutely not increase it. Nothing will increase it. Production is genetically limited. It's...

That sounds insane to me. 5-10 lbs. of muscle in a single year? Jesus. It would take me 5-10 years to build 5-10 lbs. of muscle. I once had a trainer tell me that we were going to lose an inch off of my waist (not even starting out large) per week. Man, I've never laughed so hard in my...

Calories and effort shouldn't make that much ofa difference in sustained workout progress. If you're young, slim and lift weights in any generally proper way, you should gain muscle. Men in prison with very less than ideal conditions gain muscle. High stress, low sleep, no control over diet...

For those that said they gained muscle with low SHBG: Did you become muscular or just "gain muscle?" I've been able to gain strength in the gym. No doubt about that. It's very slow. Almost as if I'm female. However, zero... and I mean ZERO size gains have ever come my way. I still have my...

Many suggest Clomid for low SHBG cases. One of its isomers acts as an estrogen receptor agonist. The biggest hole in this theory, for me, is that if having excessive estradiol isn't upping SHBG production, why would a mild estrogen receptor agonist? The crux of the low SHBG issue is that...

Low SHBG is its own issue, irrespective of other hormones. SHBG is a stand-alone hormone with its own receptor (SHBG-R) as well as a transport and storage mechanism for every major steroid hormone. To say low SHBG is no big deal is the same as saying low vitamin D is no big deal as long as you...

MENT is not a hair safe drug. I don't know why you'd switch to this after having to drop your T.

Technically, the clear vial is the wrong one to use. Testosterone is light sensitive and is often dispensed with a "protect from light" warning. One is supposed to store it in the original box. If one does not, and the vial is clear, you could lose potency. However, I've never seen a source...

What is the dose that you consider to be high? I tried 50mg every three days SQ, but that gave me insane prostate issues. Like actual semen coming out before a piss. So, instead of battling high E2 sides, I was battling high FT sides! Injecting insulin is VERY different than injecting an...

I'm rogue, too. My 200 mg/wk is not prescribed. You say Dr. Saya consents to anastrozole only when you feel you need it. What exactly to do you feel that lets you know that your estrogen is too high? At 200 mg/wk, I feel nothing from T. Not even a single boner. So, toying with anastrozole...

There's a big difference between your experience, Vince, and the experiences of the majority of men with low SHBG. For the majority of men, there is no cure. Just ask ERO, or a number of members of Dr. John's own messageboard. Your case is interesting because you "feel it" and then you bottom...

I keep hearing people say that there are medications that can increase SHBG. When questioned, they back down. Are there actually any medications that reliably increase SHBG? - Estrogen is out of the question, because all of us with low SHBG already have high estrogen to begin with. The liver...

Here's a better explanation of the problem: I cross the FT threshold even at a tiny, tiny dose of testosterone: If anyone thinks this is "awesome," I think you need to turn in your bro card.

James, The reason for taking HIGHER doses of testosterone with low SHBG is that the leading theory for why SHBG is so vital is that it acts as a promoter of signaling at the androgen receptor and is vital for update of T in certain tissues. If you can't get proper AR signaling because you lack...

Vince, Did you actually start out with low SHBG? Specifically, did you have low T and low SHBG where the low SHBG persisted when your T became normal [(600 - 900ng/dl) with low SHBG (< 20 pg/mL)?] Or, did you develop your low SHBG as a symptom of your 150-200mg/wk T dosing? These are two...

I used GH stimulating peptides. They don't work. SHBG is the same after 2x daily dosing of 100 mcg ipamorelin and mod GRF-129. My source is that ultra-reputable one that everyone knows about. I see people raving about great sleep and 10 years coming off of their face. Bullshit and...

This thread got way off topic. Does anyone have any clues as to how one can increase SHBG output to normal levels, or how to use normal TRT doses in combination with chronically low SHBG?

I've been lifting on an off with incredible FT values, but low SHBG. Like ERO, I eat 3,000 calories per day. I'm 185 lbs @ 16% BF, but all of the calories go straight to my gut. Not even to "fat" -- but just straight to the gut. I am FAT-FREE on arms and legs and face. How people end up with...

I bumped my T up from 80mg/wk to 200mg per week. With a >5% FT ratio, I'm going to have insane FT values. Having insane free testosterone might be the only way to make low SHBG work, per some people who have found success.