Recent content by in_TRT

This might be a relevant discussion.. Calculate free testosterone with TruT by FPT

Agreed.. Hopefully accurate calculators based on experimental data can be published.. Like the discussion initiated in the other board: Calculate free testosterone with TruT by FPT

Free E2 measurement (by validated dialysis with LS MS/MS) might turn out to be important till we truly understand how the E2 binds to SHBG.

What about Free Estradiol in men?

The older papers have too many simplistic assumptions. I quote the text from figure 2 of the paper you cited: Figure 2. Bland–Altman plots comparing cFT (right) and RIA (left) against EqD. Mean bias is 0 [95% CI 29.4 to 29.4] for RIA and -19.4% [95% CI 45 to 6.1] for cFT. How do we reconcile...

Vermeulen was proposed on simplified assumptions before even the structure of SHBG was known..

Not so.. Figure 5 seems to show that there is no direct (linear) correlation. I may be wrong!!

This is the central problem. If the measurement (of total and free) is not precise then dosing becomes a trial and error. Either the person gets to supra-physiological or sub-therapeutic levels. Contributors to the substantial variation in on-treatment testosterone levels in men receiving...

Also ask, what laboratory assays will they use to determine total and free T levels.. Free T calculation will become important if SHBG levels change..