Looking for published papers on trt+hcg + fsh

[hfbjr]

I'm currently on 60 mgs testosterone cyp x2 week, along with 1666 IU'S of HCG. I want to add fsh, but my fertility doc thinks it's too early, although he will go along with it, providing I can find some studies to show him. He also would like the studies to provide to my insurance company, which surprisingly, has been wonderful so far, covering my hcg.

Thank you so much

 

[Systemlord]

I want to add fsh, but my fertility doc thinks it's too early

I can find some studies to show him.

You shouldn't need studies to prove you're right, this is the doctor's specialty and there should be no doubt on the effectiveness of FSH on sperm parameters.

FSH dosage effect on conventional sperm parameters: a meta-analysis of randomized controlled studies - PMC

Follicle-stimulating hormone (FSH) represents a therapeutic option in normogonadotropic patients with idiopathic oligozoospermia. The aim of this review was to evaluate the possible dose- and drug-dependent efficacy of FSH treatment on conventional ...

www.ncbi.nlm.nih.gov

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[hfbjr]

Yes., it's my fertility doc. He wants data to show the insurance company, vs waiting down the road, as I'd like to stsrt it now. He's perfectly OK with starting it, bit says he needs something to present to them

 

[Vince]

Semen analysis results after adding FSH to TRT and hCG - Excel Male TRT Forum

So after 6 months of adding FSH to my TRT protocol I got a sperm analysis done. A quick background. My fertility was normal before TRT and went to zero when I started TRT without HCG. Adding HCG 500 IU 2x a week my sperm analysis results were: sperm count 2.1mm (normal >=20mm) total sperm...

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[hfbjr]

Thank you Vince

 

[hfbjr]

I'm looking for LDr. Larry lipshultz paper on it, but cannot locate it online

 

[Vince]

I'm looking for LDr. Larry lipshultz paper on it, but cannot locate it online

FSH and hCG dual therapy may result in the more rapid recovery of sperm to the ejaculate - Excel Male TRT Forum

024 Dual Therapy with rFSH and HCG Results in a Significantly Shorter Time to Return of Spermatogenesis than Combination HCG and Clomiphene (2021) K. Campbell, J. Sullivan, R. Valero Carrion, J. Kraus, B. Stocks, A. Lawrence, L. Lipshultz Introduction: The use of testosterone replacement...

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[hfbjr]

FSH and hCG dual therapy may result in the more rapid recovery of sperm to the ejaculate - Excel Male TRT Forum

024 Dual Therapy with rFSH and HCG Results in a Significantly Shorter Time to Return of Spermatogenesis than Combination HCG and Clomiphene (2021) K. Campbell, J. Sullivan, R. Valero Carrion, J. Kraus, B. Stocks, A. Lawrence, L. Lipshultz Introduction: The use of testosterone replacement...

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Vince, that is just what I needed. This will make my gf relieved, as we are both now seeing the same doc. Thanks a million.

 

[madman]

Vince, that is just what I needed. This will make my gf relieved, as we are both now seeing the same doc. Thanks a million.

Look over this thread!

Fertility maintenance or restoration in men before, during, and after TRT or AAS - Excel Male TRT Forum

Fertility Preservation in Hypogonadal Men (2018) Robert J. Carrasquillo and Ranjith Ramasamy Introduction Testicular failure is defined as the impairment or loss of both the endocrine functions of the testis (production of testosterone, or T) and exocrine function (production of...

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[madman]

Vince, that is just what I needed. This will make my gf relieved, as we are both now seeing the same doc. Thanks a million.

post #3

Restoring spermatogenesis in hypogonadotrophic hypogonadism - Excel Male Men's Health Forum

Hypogonadism is a deficiency in one of the testes’ two major functions: (a) testosterone secretion (endocrine function) and (b) spermatogenesis (reproductive function). The two types are known as primary (hypergonadotrophic) hypogonadism (testis failure) and secondary (hypogonadotrophic)...

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*The findings suggest that normal qualitative and quantitative sperm production is best maintained in the presence of both FSH- and LH-induced testosterone secretion. Human chorionic gonadotrophin (hCG) in conjunction with FSH is a common regimen for inducing spermatogenesis

*Although hMG has both FSH and LH activity, FSH activity predominates, and LH activity is so low that fertility requires a combination of hCG and hMG

*More recently, highly pure urinary FSH preparations have been created, with higher specific activity than hMG. Recombinant human FSH formulations have greater purity and specific activity than any urinary preparation and no inherent LH activity

*Typically, hCG alone at a dose of 1000IU on alternate days or twice weekly is usually used to start gonadotrophin therapy, with the dose titrated based on trough testosterone levels and testicular development

*Due to residual FSH secretion, spermatogenesis can be begun with hCG alone in most individuals with bigger testes at baseline

*Once there is a plateau in the response to hCG, which typically occurs at around 6 months, therapy with FSH (in one of the three forms described above) should be added at a dose of 75IU on 3 days per week. If sperm output and testicular growth remain suboptimal, the dose of FSH can be gradually increased to 150IU daily

*Gynaecomastia is the most prevalent side effect of gonadotrophin therapy and is caused by increased oestradiol release due to hCG activation of aromatase

*Pulsatile administration of GnRH, which can be via a programmable, portable mini-infusion pump, provides an alternative to gonadotrophin therapy. FSH–hCG therapy provides two advantages over GnRH therapy: subcutaneous delivery and greater efficacy in cases of GnRH receptor mutation (about 10% of normosmic congenital hypogonadotrophic hypogonadism)

 

[madman]

Vince, that is just what I needed. This will make my gf relieved, as we are both now seeing the same doc. Thanks a million.

Continuous Testosterone Therapy with Recombinant FSH & HCG Improves Semen Parameters - Excel Male TRT Forum

Continuous Testosterone Therapy with Recombinant FSH & HCG Improves Semen Parameters: A Pilot Study (2022) THakky, HShirazi, MChristensen, APastuszak Introduction Male hypogonadism is characterized by inadequate production of Testosterone (T) and a deficiency in spermatogenesis. The main...

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