3.5 years on TRT and feeling no effects. Time to give up?

It's been about three weeks and I feel OK. Still feeling indifferent on every topic of my life but that's been the norm for years......Still looking for relief.
 
Not feeling it! :(

Since it doesn't look like it has been said yet: Have you tried running higher numbers?

If my FT were a hair above 20, I don't think I'd be getting much out of TRT either. When FT is in upper 20s/low 30s is when I start to see benefits.

Also, why did you start TRT in the first place - what specific issues were you hoping it would address?
 
Trt definitely kills libido in a good number of men. I’ve seen it too many times and talked to several men stating the same.
 
I’d be curious to know this as well
I am currently on 500 hcg eod. And I feel much better than my testosterone protocol. Which I stopped earlier.

the thing is hcg used to work and not work I don’t know why but the last two weeks It was consistently working not sure why but these could be the reason:
1- when I mix hcg I used not to shake it so I rotate the bottle slowly. And when injecting the water inside just press on it.
But now I am super super gentle very gentle don’t even rotate it just move slowly to mix them and when I inject I let it drop down slowly and not just press quickly.

also I take vitamin k2, vitamin d, lysin, vitamin c and iron (to restore my irons level) not sure if they help if they do it could be k2 or vitamin c will check this later if it continues working.

I 100% convinced that hcg alone is more than enough if your leydig cell is still working.

no hematocrit issue, all hormone goes up smoothly not only testosterone. I only hope to see this continues (it’s been almost two successful week) and hope my leydig cell continue working.

my normal T is around 10 with hcg I reach 17. Which is good.
 
I also think there is a potential in clomid I did 25mg EOD and morning wood didn’t stop. Now I am testing if I take like once or two a week to see if it actually help a bit with hcg
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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