When to correctly test estradiol levels (the facts).

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SixHouse

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Posted about this last week and "Vince" the forum police gave incorrect information and then locked the thread. Pretty irresponsible thing to do when people's health is at stake, but cognitive dissonance is a ***** huh?

Saw an endocrinologist to get the facts. Problem is, we're all used to testing testosterone and estrogen levels at the same time. It was explained very logically to me that what I already suspected was true: When you're treating a "low" condition, testosterone for example, you should test at the low point, which is what we all do. On the flip side, when you're treating a "high" condition, for example prescribing anastrozole to combat HIGH estradiol, then you must test at the high point. Makes perfect sense since your concern is monitoring the high point.

Sadly the only accurate way to do this is to test estradiol levels separate from testosterone. I had my last blood draw for testosterone on my normal low day, then had separate blood drawn for estradiol on a day when we reasoned e2 would be highest.

Yes we should continue to have estradiol tested at the same time we test testosterone levels. It's always good to have a general sense of e2 levels. But if you're super sensitive to e2 and anastrozole like I am, you really need to do it separately if you want to be accurate.
 
Yes we should continue to have estradiol tested at the same time we test testosterone levels. It's always good to have a general sense of e2 levels. But if you're super sensitive to e2 and anastrozole like I am, you really need to do it separately if you want to be accurate.

This makes no sense. Estradiol comes from testosterone. The lower the T, the lower the estradiol. But, heck, you can really do anything you want. No one is telling you otherwise.

Checking both T and E2 at peak and trough would be best instead of one at a time on separate occasions. The healthy ratio should be above 14 (ng/dl of T divided by m=pg/ml of E2) from two small studies on fertility.
 
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Predict estradiol, DHT, and free testosterone levels based on total testosterone

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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