Testosterone/Estradiol Ratio

JA Battle

Active Member
(a) 17‐α‐estradiol (17aE2) is a relatively “non‐feminizing” estrogen which shows reduced activation of classical estrogen receptors compared with 17‐β‐estradiol (Anstead et al., 1997). Harrison et al. (2014) reported that in UM‐HET3 mice fed 4.8 mg 17aE2/kg (4.8 ppm) diet from 10 months of age, median male lifespans increased 12% (p = 0.0012, pooled across the three sites), while 17aE2 did not alter female lifespan. Strong et al. (2016) showed that using a threefold higher dose (14.4 ppm) from 10 months of age, pooled median male lifespans increased 19% (p < 0.001); the 90% lifespan increased 12%, but females still did not benefit. Thus, only males were tested in the present study. To determine whether 17aE2 treatment is effective when initiated in older mice, males were treated beginning at 16 or 20 months of age, choosing middle age, and early old age before many natural deaths.

I feel like it’s crazy that I inject estrogen but I’m going in for 24mcg estradiol valerate daily bloodwork on Monday. I don’t think it moved my e2 level much. I think I still have low e symptoms. But before I change dosage I must know for sure. I’m testing trough and 5 hours after injection to see if there is any fluctuation with such a tiny dose of the valerate ester. Valerate has a shorter half life than enanthate but longer half life that propionate.
 

Cataceous

Well-Known Member
I feel like it’s crazy that I inject estrogen but I’m going in for 24mcg estradiol valerate daily bloodwork on Monday. ...
I wouldn't hesitate to do this if I had inadequate aromatization. A lot better control than trying to get it indirectly through hCG.
 

Match

New Member
Isso era geralmente 70 mcg EOD, cerca de um quarto de miligrama por semana.
T 637 e Estradiol 32. Penso usar Anastrozol 0,5mg por semana. O que acha? SHBG meio alto 62 nomol / l (nao sei que relalçao tem com Estradiol)
 
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Cataceous

Well-Known Member
T 637 e Estradiol 32. Penso usar Anastrozol 0,05mg por semana. O que acha? SHBG meio alto 62 nomol/l (nao sei que relalçao tem com Estradiol)
T 637 and Estradiol 32. I plan to use Anastrozole 0.05mg per week. What do you think? SHBG medium high 62 nomol / l (I don't know what relationship it has with Estradiol)
I would not use an aromatase inhibitor. Testosterone and estradiol are well balanced. If you're having symptoms of low testosterone due to your high SHBG then you should look into Natesto. This product supplements your existing testosterone and it might lower SHBG a little.
 

Match

New Member
Natesto é associado de T em gel nasal, ok? 11mg, me parece.
Mas requer receita médica, ok?
Quanto ao SHBG, reduzindo um pouco o Estradiol com IA não reduz tb SHBG?
 

Cataceous

Well-Known Member
Natesto is associated with T in nasal gel, ok? 11mg, it seems to me.
But it requires a prescription, okay?
As for SHBG, reducing Estradiol with AI a little does not reduce tb SHBG?
Yes, Natesto does need a prescription. I would not attempt to use an AI to manage SHBG, particularly when starting from a healthy normal level of estradiol. At least for me, modest changes in estradiol don't have much effect. Only when estradiol was undetectable did my SHBG also crash.
 

Match

New Member
OK. É que Estradiol tb talvez um pouco acima. T / E 637/32 = 19
Mandei já 0,5mg de Anastrozol e manter só uma vez por semana, pra ver o que ocorre
 

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