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For some people losing weight is very hard.  My wife for instance is very experienced with diets as she is a former IFBB Pro in the heavy weight BB division.  She has been on diets all her life.  But as she ages nothing seems to work.  She cut all see oils years ago, has been on keto most of her life, goes to the gym 4-5 tims a week, etc etc.  She has a leptin issue and can't control her hunger.   She insisted on doing this stuff and it has so far worked pretty well.  

Side effects occur in almost anything we take.  I took the supplement cissus and ended up in the hospital with pancreatitis.  Like all supplements and medications, buyer beware.  The incident of pancreatitis is rare with this semaglutide, but if you are one of the ones who get it, the incidence is too high.  Metformin for me works very well.  I can take 500mg/d and drop 10 lbs in a few week, eating the same calories. I will not be trying semaglutide anytime soon.