Official Natesto Thread

Buy Lab Tests Online
Defy Medical TRT clinic doctor

TLawyer

Active Member
We want to test at peak when using Natesto.

Maximum concentration (Cmax) is achieved within approximately 40 minutes.

I would have blood drawn 1 hr post-dose.

Even then if you just started I would give it some time to see how your body reacts before rushing to get labs.


Figure 1: Mean Serum Total Testosterone Concentrations on Day 90 in Patients Following NATESTO 22.0 mg Daily Administered at 9 p.m. and 7 a.m. (N=122) and 33.0 mg Daily Administered at 9 p.m., 7 a.m. and 1 p.m. (N=151)
View attachment 19041


Recommended Dose and Dosage Adjustment


The recommended starting dose of NATESTO (testosterone) is 11.0 mg of testosterone (1 actuation per nostril) administered intranasally twice daily for a total daily dose of 22.0 mg.

To ensure proper dosing, serum total testosterone concentrations should be measured after initiation of therapy to ensure that the desired concentrations (300 to 1050 ng/dL) are achieved.
The NATESTO dose can be adjusted at least 30 days after starting treatment based on the serum total testosterone concentrations from a single blood draw, taken 20 minutes to 2 hours after morning administration of NATESTO. If the total testosterone measurement is less than 300 ng/dL, the daily testosterone dose may be increased from 22.0 mg (twice daily administration) to 33.0 mg (thrice daily administration), as instructed by a physician.

Serum total testosterone concentrations should be checked periodically. The following rules should be applied:

* For patients on 22.0 mg (twice daily administration):
If the measured serum total testosterone concentration from the single morning blood draw is less than 300 ng/dL, the daily dose of NATESTO may be increased from 22.0 mg (twice daily administration) to 33.0 mg (thrice daily administration);

*For patients on 33.0 mg (thrice daily administration): If the measured serum total testosterone concentration from the single morning blood draw is consistently less than 300 ng/dL, or if a desired clinical response is not achieved, NATESTO should be discontinued and an alternative treatment should be considered.

*If a post-dose morning total testosterone concentration consistently exceeds 1050 ng/dL, NATESTO should be discontinued.
What's your thought process on waiting until getting tested? If it's short-lived and doesn't build up in your system, it would seem like you could get tested after one dose and get an accurate read of what level you can expect to hit going forward.
 

Willyt

Active Member
Having experimented with Natesto, I can certainly see its appeal as the most minimally disruptive form of TRT. And if it works for you great.

However, I keep coming back to the long-term challenges with Natesto or any nasal form of TRT. The recommended 3x daily (each nostril) means over 1,000 nasal squirts per nostril each year. TRT is a lifetime commitment. Taken over 20 years, you're looking at squirting that stuff into your nasal membranes over 20,000 times.

My concern is not with the effort of 3x daily, but rather the long-term health of your nasal membrane. Even after absorption, the membrane is bathing in that gel for 24/7. My intuition tells me that is probably not a good idea. Could this damage your smell or taste over a period of years?

Here are the ingredients of Natesto:
  • Testosterone (4.5% concentration)
  • Castor oil (solvent)
  • Oleoyl polyoxylglyceride (wetting agent)
  • Colloidal silicon dioxide (viscosity increasing agent)
 

CKO

Member
TLawyer, thanks for trying this combination. I've been considering going back on in enclomiphene and had wondered if they would allow someone to try nasal application at the same time. I'll be curious to watch your results and subjective outcomes. My labs always looked great on enclomiphene, but the subjective benefits were not there for me. Wondering if this is a viable option.
 

TLawyer

Active Member
TLawyer, thanks for trying this combination. I've been considering going back on in enclomiphene and had wondered if they would allow someone to try nasal application at the same time. I'll be curious to watch your results and subjective outcomes. My labs always looked great on enclomiphene, but the subjective benefits were not there for me. Wondering if this is a viable option.
Well, I actually took my last dose of Enclomiphene 5 days ago and have been going just with the nasal gel (3 applications per day, 10 mg total each application). I just wanted to see what the nasal gel would do alone. So far, seems ok. I feel a little lower than when on the Enclomiphene as well, but normal. I'm going to try going with this for a few weeks, take labs, and then re-assess whether to add back in the Enclomiphene.
 

TLawyer

Active Member
Having experimented with Natesto, I can certainly see its appeal as the most minimally disruptive form of TRT. And if it works for you great.

However, I keep coming back to the long-term challenges with Natesto or any nasal form of TRT. The recommended 3x daily (each nostril) means over 1,000 nasal squirts per nostril each year. TRT is a lifetime commitment. Taken over 20 years, you're looking at squirting that stuff into your nasal membranes over 20,000 times.

My concern is not with the effort of 3x daily, but rather the long-term health of your nasal membrane. Even after absorption, the membrane is bathing in that gel for 24/7. My intuition tells me that is probably not a good idea. Could this damage your smell or taste over a period of years?

Here are the ingredients of Natesto:
  • Testosterone (4.5% concentration)
  • Castor oil (solvent)
  • Oleoyl polyoxylglyceride (wetting agent)
  • Colloidal silicon dioxide (viscosity increasing agent)
Certainly a valid concern and one that is on my mind. One thought I have is to actually get the more concentrated gel from Empower that is 10 mg, or double the Natesto dosage. That would at least cut down on the amount of some of the gel. It’s currently 8 clicks with the 5 mg, so I should be able to go with 4 clicks with the 10 mg (unless I am thinking about it wrong). I think that’s cheaper as well.
 

madman

Super Moderator
What's your thought process on waiting until getting tested? If it's short-lived and doesn't build up in your system, it would seem like you could get tested after one dose and get an accurate read of what level you can expect to hit going forward.

Of course, you can get blood work done right away to see what peak levels are achieved post-application.

Would rather wait a few weeks to see how you feel overall let alone get into a groove using the applicator.
 
Buy Lab Tests Online

Sponsors

bodybuilder test discounted labs
Defy Medical Telemedicine hormones
Discounted lab tests
TRT in UK Balance my hormones
Testosterone books nelson vergel
Free Testosterone Book
Register on ExcelMale.com
Trimix HCG Offer Excelmale
Thumos USA men's mentoring and coaching
Testosterone TRT HRT Doctor Near Me

Online statistics

Members online
13
Guests online
5
Total visitors
18

Latest posts

Top