Urology Times® is celebrating its 50th anniversary in 2022. To mark the occasion, we are highlighting 50 of the top innovations and developments that have transformed the field of urology over the past 50 years. In this installment, Amy Pearlman, MD, interviews Mohit Khera, MD, MBA, MPH on how advancements in testosterone therapy have changed treatment modalities across urology, providing patients with more efficacious, individualized care. Khera is a professor of urology and director of the Laboratory for Andrology Research, and director of the Executive Health Program at the McNair Medical Institute at Baylor College of Medicine in Houston, Texas. Pearlman is a clinical assistant professor of urology and the director of the Men’s Health Program at the Carver College of Medicine at the University of Iowa Health Care in Iowa City, Iowa.