Heart Rate Variability

[Nelson Vergel]

According to multiple sources, beta-blockers have been shown to increase heart rate variability (HRV) in patients with heart failure and other conditions [1, 2, 3, 4, 5]. Beta-blockers slow down the heart rate by blocking the effects of the hormone epinephrine (adrenaline), causing the heart to beat more slowly and with less force [10]. This reduction in heart rate is thought to allow for greater variability in the time between heartbeats, leading to an increase in HRV [3]. However, it should be noted that the effect of beta-blockers on HRV may vary depending on the patient's condition and the specific medication used [1, 2].


Nebivolol is considered a unique beta-blocker due to its ability to improve nitric oxide (NO) bioavailability and release, leading to better heart rate variability (HRV) and endothelial function compared to other beta-blockers [1]. In contrast to other beta-blockers, nebivolol does not inhibit the increase in heart rate typically seen with exercise, allowing for improved HRV and autonomic function in patients with heart failure [1]. Additionally, nebivolol is shown to have an effect on small muscular arteries, increasing pulse pressure amplification and reducing wave reflection, possibly due to increased NO levels [4]. Nebivolol has been demonstrated to reduce heart rate and increase ejection fraction, decrease left ventricular end-diastolic pressure, pulmonary capillary pressure, and peripheral vascular resistance in patients with Class I-II heart failure patients with an ejection fraction lower than 24% [8]. Overall, nebivolol may be a better beta-blocker to improve HRV due to its unique NO-mediated effects and lack of inhibition of exercise-induced heart rate increase.

 

[tareload]

AI prompt engineering: Google it

I am quite aware of it. Doesn't address the database from which the large language model draws information. Largely separate issue.

 

[BigTex]

OK, what is this ChatGPT?.....OK, Isigned u for an account and will play with this.

 

[tareload]

OK, what is this ChatGPT?.....OK, Isigned u for an account and will play with this.

Thread 'Chat GPT - What AI has to say about dosing' Chat GPT - What AI has to say about dosing

See post here from Wolfram

 

[tareload]

Post in thread 'Chat GPT - What AI has to say about dosing' Chat GPT - What AI has to say about dosing

This one specifically.

 

[BigTex]

Thread 'Chat GPT - What AI has to say about dosing' Chat GPT - What AI has to say about dosing

See post here from Wolfram

The make it sound pretty simple huh?

 

[tareload]

The make it sound pretty simple huh?

Complexity is in the eye of the beholder.

 

[BigTex]

I played with this a little yesterday and see that undergraduates might be able to use this to write reports, especially with some of the crap the English department has them do on books. Might be better than Cliff Notes.

I kind of like this disclaimer:

While we have safeguards in place, the system may occasionally generate incorrect or misleading information and produce offensive or biased content. It is not intended to give advice.

 

[BigTex]

WOW! It could also be used when doing tests in exercise science.

I still remember this from my masters degree exercise physiology final -

Explain the sliding filament theory:

The sliding filament theory is a scientific explanation of how muscles generate force and contract. It is widely accepted by scientists and forms the basis for our understanding of muscle physiology.

According to the sliding filament theory, muscle contraction occurs when the thin filaments (made of actin) slide past the thick filaments (made of myosin) within muscle fibers, resulting in the shortening of the muscle.

The process of muscle contraction is initiated by a signal from the nervous system, which causes the release of calcium ions within the muscle fibers. These calcium ions bind to the protein complex called troponin, which is located on the thin filaments.

As the troponin binds with calcium ions, it undergoes a conformational change, which causes the tropomyosin (a protein that covers the actin binding sites) to move away from the myosin-binding sites on the actin. This exposes the binding sites on the actin, allowing the myosin heads to bind to them.

Once the myosin heads bind to the actin, they undergo a conformational change, which pulls the thin filaments towards the center of the sarcomere (the functional unit of muscle fibers). This shortens the sarcomere, resulting in the overall contraction of the muscle fiber.

This process is repeated numerous times as the myosin heads continue to bind to the actin and pull the thin filaments towards the center of the sarcomere until the muscle is fully contracted. The sliding filament theory provides a detailed explanation of the molecular mechanisms that underlie muscle contraction and helps scientists understand the physiological basis of muscular diseases and disorders.

Holy crap, I figure I could write a book using this.

Just tried something else......it writes code!

I do see a tint of biase in some of the stuff written.