I was having sore nipples for about 3 weeks after starting. this has subsided.But think it might be elevated E2, since I have not lost any fat aroung my midsection in spite of eating well and increasing exercise
Sometimes when initiating GH therapy water retention results. It's basically the body shifting water between compartments. It evens out.I have searched a lot for studies that explain why water retention is so much more common in some men than others when starting testosterone replacement. I have only found one that was done in men with low thyroid function who were exposed to growth hormone alone, testosterone alone and GH+T combination. They speculate that either GH or testosterone may affect water balance (increasing water outside the cells or extracellular water) by an effect on kidney tubules.
I have been reading a few bodybuilding sites that say that increasing water intake may help decrease water retention. Also, some bodybuilders use diuretics once in a while to decrease water retention.
I find that when I consume more carbs than I should, my water retention considerably goes up. Eating meats, eggs, dark green vegetables, nuts, etc and avoiding sweets, sodas, white breads/crackers, high salt consumption and pasta also help me not hold water so much. Cardio also helps me lower water retention considerably.
Jill is certainly correct. Just changing hormone levels can bring on untoward--or beneficial--side effects. Like dropping a pebble in a pond, things even out. We may see some initial nipple tenderness, water retention, increased (or decreased) libido....all temporary, and just because levels are changing. Who remembers puberty?Awh great news! You nailed this right on the head Nelson. The RN from Defy responded back to me and said the same exact thing.......with some of us starting TRT causes a sensitivity to the hormone Aldosterone which regulates sodium retention. If you are one of these guys (like me), the start of TRT can cause the sensitivity to Aldosterone....., which begins to have difficulty regulating sodium, which causes water retention. The good news she says....(just like the study referenced by Nelson) is this usually subsides itself in the next couple of weeks (maybe up to two months) after initial flare up. She offered to prescribe a diuretic for the next 30 days for relief until it subsides itself. Nelson, thanks again for sharing the info......this helped be well informed when the RN from Defy contacted me. Thanks again.