People lay a lot on "Studies suggest"...which is so very flawed. Of the guys I can think of on this forum that use Metformin I can't think of one that has experienced an increase in SHBG.I have seen people say that studies suggest Metformin raises SHBG but I haven’t seen anyone say that Metformin actually raises SHBG through their own experience. My SHBG ranges from 8.9 to 11. Has anyone seen their SHBG raise as a result from taking Metformin?
The article states that "Production Signals: Estradiol, triiodothyronine (T3)".
I wonder how much this all affects SHBG, to what degree?T3 has a lot stronger effect on stamina than free testosterone. If you have low T3, increasing it will have a stronger effect on "feeling good" than a drop in free testosterone would have on "not feeling good".
Most good docs know that it is better to improve low thyroid first and then go for TRT if needed.
TRT also decreases thyroid binding globulin, by the way. That is why it is important to have a doctor that knows how to treat hypothyroidism and hypogonadism if you have both issues.
Does Testosterone Replacement Affect the Thyroid?
IMO we all tend to overlook the possibility that one thing, Metformin, had noting to do with the other thing, eliminating your acne. Metformin should have lowered your blood glucose, maybe that was it?I did full blood work right before taking Metformin. In 2 more weeks it will have been a month on Metformin. I am going to test Total T, Free T, SHBG and a few other things.
What I find really interesting is Metformin eliminated TRT induced acne. I don’t know why, maybe it lowered my free T.
It had zero effect on raising mine and I have never seen anyone say it has on any TRT forum, either. The idea comes from the thought that I'd a guy has low SHBG then he must be fat and diabetic or pre diabetic, there for Metformin should "fix"him.I have seen people say that studies suggest Metformin raises SHBG but I haven’t seen anyone say that Metformin actually raises SHBG through their own experience. My SHBG ranges from 8.9 to 11. Has anyone seen their SHBG raise as a result from taking Metformin?