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You should never take a drug, a supplement, anything, that you aren't comfortable with. However, there is a significant long-term risk in not controlling blood sugar levels. I don't use Meformin, but did use Berberine for a time - was pleased, but decided to set it aside and increase my activity levels to see if (one last try) would bring things into line. They did respond. I would have turned to Metformin had those efforts failed as I strongly feel the benefits it can achieve outweigh potential risks.