Axiron: Single testosterone measurement may lead to poor dose adjustment

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Nelson Vergel

Utility of a Single Serum Testosterone Measurement to Determine Response to Topical Testosterone Replacement in Hypogonadal Men[h=2]Current Medical Research and Opinion.Oct 2015[/b]

Objective: To evaluate the utility of single serum testosterone measurements in patients receiving transdermal testosterone therapy.
Research Design and Methods: Data were from an open-label, 120-day, multi-center titration trial in androgen-deficient men receiving an initial daily dose of 60 mg testosterone (testosterone topical solution 2%) applied to axillae (30 mg/axilla). Average concentration (C[SUB]avg[/SUB]) of serum testosterone (TT) was determined on days 15, 60, and 120; doses were adjusted to maintain normal C[SUB]avg[/SUB] (300-1050 ng/dL [10.4-36.4 nmol/L]). Accuracy of single serum TT measurements (2, 4, 8, 12, 16, and 20 hours post-dose) was assessed in patients with C[SUB]avg[/SUB] TT within and below (<300 ng/dL [<10.4 nmol/L]) the normal range.
Clinical Trial Registration: – NCT00702650
Main Outcome Measure: Serum testosterone levels.
Results: In patients with normal C[SUB]avg[/SUB] (n=85), 79% to 92% had serum testosterone levels within normal range 2, 4, 8, 12, 16, and 20 hours post-dose; significant effects of time post-dose single testosterone measurement accuracy (P=0.01) were observed: testing accuracy peaked 4 to 8 hours post-dose and tapered ∼16 hours post-dose. In 28/63 instances with low C[SUB]avg[/SUB] TT throughout the study a normal 2-hour serum TT level was observed. The average percentage (across all days) of discordant results between C[SUB]avg[/SUB] (<300 ng/dL [<10.4 nmol/L]) and single serum TT measurements (300-1050 ng/dL [10.4-36.4 nmol/L]) declined with increasing time from dose application (44% at 2 hours, 38% at 4 hours, 22% at 8 hours, 3% at 16 hours).
Conclusions: Reliance on a single serum testosterone measurement to determine the need for dose adjustment of testosterone topical solution 2% may lead clinicians to change the dose unnecessarily, or alternatively, not increase the dose when necessary. The results reported here are limited to testosterone topical solution 2% and may not be applicable to other topical agents.
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