I'm very sensitive to high estradiol (anything >35), especially the classic negative effects on well being. However, in the rare instances that my estradiol is low, I've definitely used topical estradiol cream. It fixes my low estradiol symptoms, also related to well being, in very short order.
Regarding libido, I'm not sure my estradiol levels really affect that. My desire for sex is pretty much constant no matter what. However, my ability to get and maintain an erection, and quality of orgasm is greatly impacted when estradiol is either high or low.