Another clue as to why TSH doesn’t suppress with thyroid replacement therapy

Buy Lab Tests Online


In my case, FT3/FT4 levels are within range (upper limit of FT3) but the pituitary hormone TSH has not been responding to thyroid replacement as I previously posted on.

More investigation reveals that I carry the Thr92AlaD2 variant which predisposes me to a T4-T3 conversion defect (+/+ [C/C] for this SNP) via decreased DIO2 enzyme. This may be why some patients seem to fail T4 monotherapy. There may also be as-yet unknown thyroid hormone resistance selective pituitary variants in my genome that could be why my TSH hasn't suppressed on meds.

Combination (T4/T3) therapy is warranted, but at what ratio? NDT has a 4:1 T4 to T3 ratio and there is some dispute as to whether that is an optimal level for functioning (some say too much T3), as research suggests there is a wide variance in the ratio in humans.

Some people have dropped the dose of NDT and added T4 to adjust the ratio to a tolerable level. Lots of tweaking involved.

Bottom line: In addition to everything else discussed here, it would seem that individual thyroid genetics need to be taken into account as well.
Last edited:
Defy Medical TRT clinic doctor
Buy Lab Tests Online


bodybuilder test discounted labs
Defy Medical TRT clinic
Discounted Labs
cheap hcg viagra cialis
TRT in UK Balance my hormones
Testosterone books nelson vergel
Free Testosterone Book
Register on
Trimix HCG Offer Excelmale
Thumos USA men's mentoring and coaching
Testosterone TRT HRT Doctor Near Me
how to save your marriage

Online statistics

Members online
Guests online
Total visitors

Latest posts