madman
Super Moderator
In conclusion, all together, our results suggest the possibility that the persistently high E2 levels associated with obesity leads to ESR1 downregulation in adipocytes and reduced E2 sensitivity, which in turn results in attenuated fat mass loss in response to T therapy. Oestrogen resistance induced obesity was first described in a man with an inactivating mutation of the ESR1 [10]. Lack of E2 action predispose to metabolic syndrome, type 2 diabetes and cardiovascular events [6], conditions that affect both genders [8]. The identification of optimum serum E2 associated with the best E2 sensitivity and body composition profile is of clinical relevance, especially considering its influence on the response to hormone therapy as observed in our study. This is the first study showing: (1) the optimum E2 levels
associated with better body composition in HG men, (2) the existence of different E2 sensitivity based on circulating E2 and (3) its influence on the response to T therapy. Prospective investigations with a bigger sample size are needed to confirm our observation and to explore consequences of E2 resistance among individuals with hyperestrogenemia.
associated with better body composition in HG men, (2) the existence of different E2 sensitivity based on circulating E2 and (3) its influence on the response to T therapy. Prospective investigations with a bigger sample size are needed to confirm our observation and to explore consequences of E2 resistance among individuals with hyperestrogenemia.
