Is Metformin a Miracle Drug ? : Nelson Vergel Explains

Nelson Vergel · Oct 15, 2017

Jay Campbell invited me to present a review of relevant data on the use of Metformin in men with and without diabetes. I hope you enjoy the work I put into explaining the data to clarify the myths and facts about this old drug that is creating so much interest in the anti-aging world.

Guided_by_Voices · Oct 22, 2017

Nelson,

Thanks a lot for putting this together. I made it all the way through and I learned a lot. A few comments:
- I think the question on whether it is beneficial for “non-diabetics” needs to take into account that the damage from diabetes has been shown to start well before blood sugar rises into “diabetic ranges”, and even before it starts to rise at all due to the insulin rise shown in the work of Dr. Kraft.
- If it turns out to have an mTOR inhibiting affect beyond what would come from its inhibition of insulin, then that could make it a sort of poor man’s rapamycin.
- There seems to be a lot of reports online that is has a pro-erectile affect beyond what could be accounted for in its well-studies actions, so that is likely to be of interest to many here.
- It will be interesting to see the results of the TAME study, although for the type of health events they are looking for, 5 years is a fairly short period of time to expect to see a large impact, but it will be interesting to see anyway.

I’m on a lower dose than discussed here and I am cycling it so that I take it primarily around higher carb meals and away from my heaviest activity days, so I’m interested to see how it goes. I’m also hoping for a noticeable anti-inflammatory effect for my knees so we will see. I'll be looking forward to the peptide discussion.

Howardb · Nov 11, 2017

Metformin to Augment Strength Training Effective Response in Seniors (MASTERS): study protocol for a randomized controlled trial

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-1932-5

Study has potential potential to make Metformin the new crack for 60+. Personally, I'm finding it is making me weaker in the gym and sleepy afterwards. Some research suggests it might suppress mitochondrial ATP production in muscles by as much as half which would explain. Met does suppress cravings for me. It becomes a pro/con trade off. I like Guided_by_Voices approach of lowering dose and cycling to avoid taking it before heavy workout days. Interested in how that is going or what others are doing.

OMI100 · Nov 15, 2017

Which type is more effective. ER or standard?

Jack Newell · Nov 15, 2017

ER 100% Much less gastrointestinal issues.

LTChris · Nov 22, 2017

Has anyone use metformin specifically for Gut issues? Such as IBS or bloating issues. I have some gut health problems and wonder if that might be worth looking into? Or if I could even get prescribed for such a reason?

FeelingLost · Nov 22, 2017

I recently read metformin can help reduce Glucose Serum. Can anyone confirm that?
How can I decide of metformin is something I should try?
I am not diabetic in fact over the last year I droped my A1c from 6.4 to 5.5 could metformin still help me get my Glucose/HDL/LDL under control?

lipids:
https://c1.staticflickr.com/5/4581/38574292171_8e3c15dfed_z.jpg

Nelson Vergel · Nov 22, 2017

It is not a toxic drug although it is contraindicated in people with kidney dysfunction. You can always try it and make sure you run a CBC and lipid panel before you do and after 8 weeks.

Nelson Vergel · Dec 18, 2017

I really like this guy's videos. Simple but comprehensive.

5337 · Jun 14, 2018

Nelson Vergel said:
It is not a toxic drug although it is contraindicated in people with kidney dysfunction. You can always try it and make sure you run a CBC and lipid panel before you do and after 8 weeks.

Nelson, you still taking this? Anyone else for that matter, Still working well??

Nelson Vergel · Jun 14, 2018

5337 said:
Nelson, you still taking this? Anyone else for that matter, Still working well??

Yes. I found a solution to my body aches that were induced by an interaction of Metformin with one of my meds: creatine.

My IBS is great and I like how less bloated I feel.

5337 · Jun 15, 2018

Cool, Thanks Nelson. I will give it a shot and see how it goes.

Nelson Vergel · Jun 15, 2018

5337 said:
Cool, Thanks Nelson. I will give it a shot and see how it goes.

Make sure you take a good B-100 complex

I use this one

5337 · Jun 15, 2018

Nelson Vergel said:
Make sure you take a good B-100 complex

I use this one

Thanks Nelson! I actually take a B12 inj every 2 weeks (no particular reason). My Doc offered it because of the IM TRT but obviously it doesn't have B1-6 in it. I'll buy some.

5337 · Jun 15, 2018

Looks like my multi isn't

too bad either. I went ahead and ordered the one you mentioned above though.

5337 · Jun 15, 2018

Rainbow light men's

Nelson Vergel · Aug 23, 2022

Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial

Men with obesity tend to be insulin resistant and often have low-normal testosterone concentrations. We conducted a clinical trial aimed to evaluate p…

www.sciencedirect.com

Fernando Almaguer · Aug 23, 2022

Nelson Vergel said:
Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial

Men with obesity tend to be insulin resistant and often have low-normal testosterone concentrations. We conducted a clinical trial aimed to evaluate p…

www.sciencedirect.com

So basically it does what it is meant to do. Lower Glucose/ Hba1c and insulin resistance?

I take it on days I do not train. After high carb meals also. 500- 750 mg.

sammmy · Aug 23, 2022

Metformin reduced by half the ER visits and hospitalizations in obese patients with COVID-19 (immunocompromised and heart failure patients excluded from study). The study did not have statistical power to make conclusions about covid deaths (too few in the study probably because of the patient selection criteria).

The proposed effect of metformin is anti-viral and anti-inflammatory.

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19

Nelson Vergel · Aug 24, 2022

Metformin, testosterone therapies lower risk for certain hormone-related cancers in men

In a large cohort of men, pre‐diagnostic use of metformin and testosterone replacement therapy was associated with lower incidence of prostate and colorectal cancers, but not male breast cancer, according to research.“The greatest reduced risks of prostate and colorectal cancers were observed...

www.healio.com