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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
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<blockquote data-quote="madman" data-source="post: 203202" data-attributes="member: 13851"><p>This is key:<strong><em> <u>long-term maintenance of sustained steady-state testosterone levels in the mid-normal range</u>, which leads to suppression of the endogenous activity of the HPG axis.</em></strong></p><p><strong><em></em></strong></p><p><strong><em><u>Topical gel formulations achieve a sustained mid-normal T level with a once-daily application</u> (8). While the topical gel results in less fluctuation of T levels between dosing intervals when compared to IM T, <u>the sustained T levels result in inhibition of HPG axis activity</u> (9). </em></strong>The inhibition of HPG axis activity is evidenced by the nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration (9).</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>Even once daily scrotal application (cream) can easily maintain steady-state mid-normal let alone high-normal physiological T levels.</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/absorption-of-testosterone-cream-via-scrotal-delivery-2018.23344/#post-200295[/URL]</p><p></p><p><em><strong>RESULTS</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Figure 1 shows the concentration profile in blood serum after administration of a 200-mg dose of testosterone via Topi-Pump and VersaBase</strong></em></p><p></p><p><strong><em>As shown in Figure 1, therapeutic levels were reached at 116 minutes and remained maintained to beyond 346 minutes. <u>Further evidence (unpublished internal data) suggests therapeutic concentrations (>1100 ng/dL) at up to 24 hours</u>. More research is needed to confirm these concentrations. Most importantly, the patient’s low testosterone symptoms resolved without adverse effects from the therapy.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 203202, member: 13851"] This is key:[B][I] [U]long-term maintenance of sustained steady-state testosterone levels in the mid-normal range[/U], which leads to suppression of the endogenous activity of the HPG axis. [U]Topical gel formulations achieve a sustained mid-normal T level with a once-daily application[/U] (8). While the topical gel results in less fluctuation of T levels between dosing intervals when compared to IM T, [U]the sustained T levels result in inhibition of HPG axis activity[/U] (9). [/I][/B]The inhibition of HPG axis activity is evidenced by the nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration (9). Even once daily scrotal application (cream) can easily maintain steady-state mid-normal let alone high-normal physiological T levels. [URL unfurl="true"]https://www.excelmale.com/forum/threads/absorption-of-testosterone-cream-via-scrotal-delivery-2018.23344/#post-200295[/URL] [I][B]RESULTS *Figure 1 shows the concentration profile in blood serum after administration of a 200-mg dose of testosterone via Topi-Pump and VersaBase[/B][/I] [B][I]As shown in Figure 1, therapeutic levels were reached at 116 minutes and remained maintained to beyond 346 minutes. [U]Further evidence (unpublished internal data) suggests therapeutic concentrations (>1100 ng/dL) at up to 24 hours[/U]. More research is needed to confirm these concentrations. Most importantly, the patient’s low testosterone symptoms resolved without adverse effects from the therapy.[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
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