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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Worsening Symptoms, "Dead Penis"
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<blockquote data-quote="Cataceous" data-source="post: 217162" data-attributes="member: 38109"><p>It's said, but rarely is it followed by an explanation. At the molecular level it's nonsense—we're using bioidentical testosterone. There's some plausibility in the argument that the lack of diurnal variation in serum levels when using products with long half-lives increases the amount needed by up to 20%. Beyond this there are vague implications that maybe higher doses somehow compensate for the disruption of other hormones by TRT. It seems dubious, though perhaps is true in some cases. There is a specific circumstance bolstered by theory: though ill-advised, it may be possible to alleviate symptoms of high estradiol with very high doses of testosterone. The reason it can work is that high serum levels of testosterone begin to saturate the aromatase enzyme, which in turn drives down the estradiol-to-testosterone ratio.</p><p></p><p>Learn from our mistakes. If you make frequent protocol changes then you can end up chasing your tail, never really figuring out what causes what. Reiterating previous advice: with the current protocol you want to ensure you've restored HPTA function and have peak testosterone at healthy levels. Then give it some time—at least another month or two.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 217162, member: 38109"] It's said, but rarely is it followed by an explanation. At the molecular level it's nonsense—we're using bioidentical testosterone. There's some plausibility in the argument that the lack of diurnal variation in serum levels when using products with long half-lives increases the amount needed by up to 20%. Beyond this there are vague implications that maybe higher doses somehow compensate for the disruption of other hormones by TRT. It seems dubious, though perhaps is true in some cases. There is a specific circumstance bolstered by theory: though ill-advised, it may be possible to alleviate symptoms of high estradiol with very high doses of testosterone. The reason it can work is that high serum levels of testosterone begin to saturate the aromatase enzyme, which in turn drives down the estradiol-to-testosterone ratio. Learn from our mistakes. If you make frequent protocol changes then you can end up chasing your tail, never really figuring out what causes what. Reiterating previous advice: with the current protocol you want to ensure you've restored HPTA function and have peak testosterone at healthy levels. Then give it some time—at least another month or two. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Worsening Symptoms, "Dead Penis"
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