Saul, My wife is receiving care at Defy with Dr. Saya for about 6 months.  She is on Testosterone cream, progesterone, dhea and natures thyroid. She is 51 and generally in good shape.  First, she has been happy with Dr. Saya and Defy as far as knowledge, care, service, etc.  What she hasn't had is a big change in how she feels.  There has been a significant improvement in wetness during sex which used to be a problem and no longer is.  However as far as body composition, sex drive, and feeling any better, she feels like the changes have not been very noticeable or significant in any way.  She is contemplating getting off some of these medications but is giving it another few months.  I hope this helps.