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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Wildly Different E2 Numbers - LabCorp vs. Quest
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<blockquote data-quote="jkozlow3" data-source="post: 126099" data-attributes="member: 20866"><p>Yes, BUT...</p><p></p><p>My Quest E2 was basically over the range a couple of months into TRT. Technically, my E2 was 39 on a trough day which was at the very top of the range. My ultra-sensitive result was WELL above the range. I also had another test result on a peak day (not trough day) of 46 with Quest that I didn't list in my original post. The 46 was done with immunoassay (non-sensitive) a couple of days before the 39 result. So I was getting results in the 39-46-54 range and was definitely "riding high" and above Quest's range.</p><p></p><p>At that point I started experimenting with Arimidex, shooting for the 20-30 sweet spot you read about everywhere.</p><p></p><p>Once I reached that sweet spot (24 with Quest), LabCorp had me at the very bottom of their E2 range. The LabCorp results were half the Quest values and I was at very different spots in the range.</p><p></p><p>So I brought my E2 down from 39 down to 24 with Arimidex on my Quest labs...this is roughly a 38% decrease in my E2. 39 is 62% higher than 24.</p><p></p><p>My LabCorp E2 was ~13. If we add 62% to this, my LabCorp E2 would have theoretically been ~21 without using an AI. If my labs had indicated an E2 value of 21, I would have NEVER started experimenting with an AI.</p><p></p><p>This is my point, and this is the problem. I don't expect LabCorp and Quest results to match identically but one lab shouldn't be giving me a result that is DOUBLE the other lab when they are using the same units and similar ranges. My Quest results led me to believe I had a potential E2 problem where as LabCorp would have likely led me to believe I most certainly did not.</p><p></p><p>If other men are using Quest exclusively, they could mistakenly be treating a non-existent E2 issue - just like I was. Then again, LabCorp could be the lab that is in error. Low E2 symptoms and high E2 symptoms are virtually identical for many men, so it's not that easy to go by symptoms alone.</p><p></p><p>The point of my thread was to raise awareness to this issue and to the discrepancy between the 2 labs - at least in my case. Perhaps something unique in my blood could cause a larger discrepancy or a false elevation that others may not experience. I have no idea. But in my case at least, something is wrong.</p><p></p><p>Could you imagine if you went to the doctor and they looked at your glucose or A1C and were told you had diabetes based on a lab result from Quest when LabCorp (had it been tested) would have given you a result that was well within range? You would be mistakenly diagnosed as a diabetic (assuming the lower LabCorp results were the accurate ones) and could end up on diabetes treatment for life. That's exactly what has happened here in my scenario. One lab caused me to seek E2 management - possibly due to erroneous results.</p><p></p><p>Again, I have no idea which lab is reporting the correct values, but I stand by my statement that this could potentially be a large problem for men on TRT if they aren't cross-referencing labs to ensure that they even have an E2 issue in the first place (according to more than one lab) before starting an AI.</p></blockquote><p></p>
[QUOTE="jkozlow3, post: 126099, member: 20866"] Yes, BUT... My Quest E2 was basically over the range a couple of months into TRT. Technically, my E2 was 39 on a trough day which was at the very top of the range. My ultra-sensitive result was WELL above the range. I also had another test result on a peak day (not trough day) of 46 with Quest that I didn't list in my original post. The 46 was done with immunoassay (non-sensitive) a couple of days before the 39 result. So I was getting results in the 39-46-54 range and was definitely "riding high" and above Quest's range. At that point I started experimenting with Arimidex, shooting for the 20-30 sweet spot you read about everywhere. Once I reached that sweet spot (24 with Quest), LabCorp had me at the very bottom of their E2 range. The LabCorp results were half the Quest values and I was at very different spots in the range. So I brought my E2 down from 39 down to 24 with Arimidex on my Quest labs...this is roughly a 38% decrease in my E2. 39 is 62% higher than 24. My LabCorp E2 was ~13. If we add 62% to this, my LabCorp E2 would have theoretically been ~21 without using an AI. If my labs had indicated an E2 value of 21, I would have NEVER started experimenting with an AI. This is my point, and this is the problem. I don't expect LabCorp and Quest results to match identically but one lab shouldn't be giving me a result that is DOUBLE the other lab when they are using the same units and similar ranges. My Quest results led me to believe I had a potential E2 problem where as LabCorp would have likely led me to believe I most certainly did not. If other men are using Quest exclusively, they could mistakenly be treating a non-existent E2 issue - just like I was. Then again, LabCorp could be the lab that is in error. Low E2 symptoms and high E2 symptoms are virtually identical for many men, so it's not that easy to go by symptoms alone. The point of my thread was to raise awareness to this issue and to the discrepancy between the 2 labs - at least in my case. Perhaps something unique in my blood could cause a larger discrepancy or a false elevation that others may not experience. I have no idea. But in my case at least, something is wrong. Could you imagine if you went to the doctor and they looked at your glucose or A1C and were told you had diabetes based on a lab result from Quest when LabCorp (had it been tested) would have given you a result that was well within range? You would be mistakenly diagnosed as a diabetic (assuming the lower LabCorp results were the accurate ones) and could end up on diabetes treatment for life. That's exactly what has happened here in my scenario. One lab caused me to seek E2 management - possibly due to erroneous results. Again, I have no idea which lab is reporting the correct values, but I stand by my statement that this could potentially be a large problem for men on TRT if they aren't cross-referencing labs to ensure that they even have an E2 issue in the first place (according to more than one lab) before starting an AI. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Wildly Different E2 Numbers - LabCorp vs. Quest
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