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Why testosterone boosts hematocrit
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<blockquote data-quote="Austinite" data-source="post: 2643" data-attributes="member: 11"><p>Hepcidin is a peptide that your liver produces. It exists to regulate iron metabolism. We're gonna come right back to hepcidin in a second...</p><p></p><p>You see, there's this protein called Ferroportin. It's job is to find cells that are holding/storing iron, and it dives inside and pulls the iron out of that cell. Now that iron is free and ready to be metabolized.</p><p></p><p>Hepcidin is released whenever your Ferroportin pulls too much iron from the cells. Hepcidin is the boss here. It's the 'master iron regulator' and wants to manage the iron so that you have a balance. So Hepcidin swims over to Ferroportin and puts handcuffs on it. Now Ferroportin is in jail and can't free anymore iron.</p><p></p><p>So what would happen if Hepcidin wasn't around to police Ferroportin? Well, Ferroportin would go nuts and start yanking all the iron out of every cell it can find. And you would end up with a whole bunch of iron in your body that's ready to be metabolized, even though it's supposed to be stored for emergencies. But wait... How is all this iron supposed to get around? It can't swim on it's own. They needs a vehicles. Are you thinking what I'm thinking? Oxygen! </p><p></p><p>Hemoglobin is the protein that lives inside of the red blood cells. It holds the oxygen that RBC's are transporting. That oxygen is like a magnet for iron. So when the red cells come around... iron hops inside the cell and binds to oxygen. Now we have oxygen, iron and hemoglobin all nice and cozy inside papa red cell. </p><p></p><p>There's a problem with this scenario, though. If Ferroportin is out of control and releasing a ton of iron, what happens when there's too much iron and not enough red cells (vehicles)? A phone call is made. "Hello? Houston! We have a problem!" (Houston is the red bone marrow that produces red cells). So this phone call is causing red bone marrow to produce a whole bunch of red cells so we can have enough vehicles to carry all this iron around. Non stop production. Millions by the second I tell ya, millions!</p><p></p><p>So now we have a ton of red cells. But hold on a minute... I know that my body didn't generate more veins to make room for all these cells. So what's going on? There must be a RIDICULOUS traffic jam in my blood. That's exactly what happened. Tons of red cells are swimming in the blood, only a lot slower than they should because of traffic. Man! My blood is jammed up and moving very slowly. Not cool!</p><p></p><p>Hmm. I remember that red cells also carry oxygen, does that mean my body is not getting oxygen fast enough? Yup! And I'm also going to have trouble breathing, causing even more problems. Oxygen deprivation also increases red cell production and inevitably, hematocrit (blood thickness) rises. </p><p></p><p>Any oxygen deprivation scenario will increase hematocrit. Sleep apnea, smoking, living in elevated areas, etc.. </p><p></p><p>Hope that helps.</p></blockquote><p></p>
[QUOTE="Austinite, post: 2643, member: 11"] Hepcidin is a peptide that your liver produces. It exists to regulate iron metabolism. We're gonna come right back to hepcidin in a second... You see, there's this protein called Ferroportin. It's job is to find cells that are holding/storing iron, and it dives inside and pulls the iron out of that cell. Now that iron is free and ready to be metabolized. Hepcidin is released whenever your Ferroportin pulls too much iron from the cells. Hepcidin is the boss here. It's the 'master iron regulator' and wants to manage the iron so that you have a balance. So Hepcidin swims over to Ferroportin and puts handcuffs on it. Now Ferroportin is in jail and can't free anymore iron. So what would happen if Hepcidin wasn't around to police Ferroportin? Well, Ferroportin would go nuts and start yanking all the iron out of every cell it can find. And you would end up with a whole bunch of iron in your body that's ready to be metabolized, even though it's supposed to be stored for emergencies. But wait... How is all this iron supposed to get around? It can't swim on it's own. They needs a vehicles. Are you thinking what I'm thinking? Oxygen! Hemoglobin is the protein that lives inside of the red blood cells. It holds the oxygen that RBC's are transporting. That oxygen is like a magnet for iron. So when the red cells come around... iron hops inside the cell and binds to oxygen. Now we have oxygen, iron and hemoglobin all nice and cozy inside papa red cell. There's a problem with this scenario, though. If Ferroportin is out of control and releasing a ton of iron, what happens when there's too much iron and not enough red cells (vehicles)? A phone call is made. "Hello? Houston! We have a problem!" (Houston is the red bone marrow that produces red cells). So this phone call is causing red bone marrow to produce a whole bunch of red cells so we can have enough vehicles to carry all this iron around. Non stop production. Millions by the second I tell ya, millions! So now we have a ton of red cells. But hold on a minute... I know that my body didn't generate more veins to make room for all these cells. So what's going on? There must be a RIDICULOUS traffic jam in my blood. That's exactly what happened. Tons of red cells are swimming in the blood, only a lot slower than they should because of traffic. Man! My blood is jammed up and moving very slowly. Not cool! Hmm. I remember that red cells also carry oxygen, does that mean my body is not getting oxygen fast enough? Yup! And I'm also going to have trouble breathing, causing even more problems. Oxygen deprivation also increases red cell production and inevitably, hematocrit (blood thickness) rises. Any oxygen deprivation scenario will increase hematocrit. Sleep apnea, smoking, living in elevated areas, etc.. Hope that helps. [/QUOTE]
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Why testosterone boosts hematocrit
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