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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why many lower their dose on ED injections
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<blockquote data-quote="madman" data-source="post: 217836" data-attributes="member: 13851"><p>As I have stated numerous times on the forum men on trt can easily achieve a high-end/high FT running a TT 1000 ng/dL even someone with high/highish SHBG.</p><p></p><p>Everyone needs to keep in mind that during the 24hr circadian rhythm of a healthy young male testosterone levels will start to increase gradually between 1-2 am reaching a peak around 8 am and this <strong><em>peak is short-lived </em></strong>as levels will start to decline over the following hours well into the afternoon/early evening reaching a trough around 7-8 pm.</p><p></p><p>Fluctuations from peak--->trough would be around 20-25%</p><p></p><p>Natural endogenous testosterone secretion is pulsatile and diurnal.</p><p></p><p>[ATTACH=full]19807[/ATTACH]</p><p>[ATTACH=full]19808[/ATTACH]</p><p></p><p></p><p></p><p>Not only have we shut down the HPG-axis through the use of exogenous T but more importantly many are forcing T levels well beyond what the body could or would ever produce endogenously let alone in their PRIME (early teens/the late 20s).</p><p></p><p>Top it off that these are steady-state levels 24/7!</p><p></p><p>No comparison between running a steady-state TT 1000+ ng/dL vs hitting a natty short-lived peak of 1000+ ng/dL.</p><p></p><p>Gets even nuttier when you have guys running absurd TT 1500+ ng/dL with FT 50-60+ ng/dL on dailies!</p><p></p><p>I believe many (myself included) do better running higher-end FT levels 20-30 ng/dL but even then we have to keep peak--->trough in mind whether injecting once weekly, twice-weekly (every 3.5 days), M/W/F, EOD, or daily.</p><p></p><p>Comes down to the individual.</p><p></p><p>Highly doubt most men need to be running absurd trough FT levels 50-60+ ng/dL to benefit from trt.</p><p></p><p>I would say many of these men CHOOSE/WANT as opposed to need.</p><p></p><p>Let alone many have dysfunctional thyroid/adrenals or other underlying issues that have absolutely nothing to do with testosterone.</p><p></p><p>As we all very well know having healthy T levels is only one piece of the puzzle.</p><p></p><p>Unfortunately too many are jacked up on T from the get-go let alone have that neanderthal mentality that more T is better.</p><p></p><p>As we say the best piece of advice is to start low and slow on a T-only protocol as we want to see how your body reacts let alone give the protocol enough time before claiming it was a success or failure.</p><p></p><p>Invest enough time to see how your body reacts to T let alone how you truly feel overall regarding relief/improvement of low-T symptoms before jacking up your dose.</p><p></p><p>Lab work is critical.</p><p></p><p>Always keep peak--->trough levels in mind.</p><p></p><p>Use accurate assays so you know where your trough TT, FT, and estradiol truly sit.</p><p></p><p>Although symptom relief is what truly matters lab work is critical as not only do we want to see where said protocol (dose T/injection frequency) has ones trough TT/FT level let alone other hormones but also to keep an eye on the impact it has on overall blood markers as we are not only trying to relieve/improve symptoms of low-t but also to minimize/avoid any potential negative effects on overall health especially long-term.</p><p></p><p>Regarding reference ranges, they are not set in stone and should be used as a guideline to give us an idea of where hormones/blood markers sit as levels could very well be too high or low resulting in negative effects.</p><p></p><p>There is nothing wrong with one running TT/FT level above range as long as you feel well overall and your blood markers are healthy.</p><p></p><p>No one is saying you have to keep your levels in a set range as the goal is to achieve the beneficial effects of having healthy FT levels while making sure overall health is maintained long term.</p><p></p><p>Do what you feel is best for you!</p><p></p><p></p><p><strong><em>*The goal of trt is to replace physiological levels of testosterone through the use of exogenous testosterone in order to achieve a healthy TT/FT level which will result in the relief/improvement of low-t symptoms while at the same time minimizing/avoiding any potential side effects (cosmetic/overall health) while keeping blood markers healthy long-term</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 217836, member: 13851"] As I have stated numerous times on the forum men on trt can easily achieve a high-end/high FT running a TT 1000 ng/dL even someone with high/highish SHBG. Everyone needs to keep in mind that during the 24hr circadian rhythm of a healthy young male testosterone levels will start to increase gradually between 1-2 am reaching a peak around 8 am and this [B][I]peak is short-lived [/I][/B]as levels will start to decline over the following hours well into the afternoon/early evening reaching a trough around 7-8 pm. Fluctuations from peak--->trough would be around 20-25% Natural endogenous testosterone secretion is pulsatile and diurnal. [ATTACH type="full" alt="Screenshot (11013).png"]19807[/ATTACH] [ATTACH type="full" alt="Screenshot (11014).png"]19808[/ATTACH] Not only have we shut down the HPG-axis through the use of exogenous T but more importantly many are forcing T levels well beyond what the body could or would ever produce endogenously let alone in their PRIME (early teens/the late 20s). Top it off that these are steady-state levels 24/7! No comparison between running a steady-state TT 1000+ ng/dL vs hitting a natty short-lived peak of 1000+ ng/dL. Gets even nuttier when you have guys running absurd TT 1500+ ng/dL with FT 50-60+ ng/dL on dailies! I believe many (myself included) do better running higher-end FT levels 20-30 ng/dL but even then we have to keep peak--->trough in mind whether injecting once weekly, twice-weekly (every 3.5 days), M/W/F, EOD, or daily. Comes down to the individual. Highly doubt most men need to be running absurd trough FT levels 50-60+ ng/dL to benefit from trt. I would say many of these men CHOOSE/WANT as opposed to need. Let alone many have dysfunctional thyroid/adrenals or other underlying issues that have absolutely nothing to do with testosterone. As we all very well know having healthy T levels is only one piece of the puzzle. Unfortunately too many are jacked up on T from the get-go let alone have that neanderthal mentality that more T is better. As we say the best piece of advice is to start low and slow on a T-only protocol as we want to see how your body reacts let alone give the protocol enough time before claiming it was a success or failure. Invest enough time to see how your body reacts to T let alone how you truly feel overall regarding relief/improvement of low-T symptoms before jacking up your dose. Lab work is critical. Always keep peak--->trough levels in mind. Use accurate assays so you know where your trough TT, FT, and estradiol truly sit. Although symptom relief is what truly matters lab work is critical as not only do we want to see where said protocol (dose T/injection frequency) has ones trough TT/FT level let alone other hormones but also to keep an eye on the impact it has on overall blood markers as we are not only trying to relieve/improve symptoms of low-t but also to minimize/avoid any potential negative effects on overall health especially long-term. Regarding reference ranges, they are not set in stone and should be used as a guideline to give us an idea of where hormones/blood markers sit as levels could very well be too high or low resulting in negative effects. There is nothing wrong with one running TT/FT level above range as long as you feel well overall and your blood markers are healthy. No one is saying you have to keep your levels in a set range as the goal is to achieve the beneficial effects of having healthy FT levels while making sure overall health is maintained long term. Do what you feel is best for you! [B][I]*The goal of trt is to replace physiological levels of testosterone through the use of exogenous testosterone in order to achieve a healthy TT/FT level which will result in the relief/improvement of low-t symptoms while at the same time minimizing/avoiding any potential side effects (cosmetic/overall health) while keeping blood markers healthy long-term[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why many lower their dose on ED injections
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