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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why is my Estradiol levels off the charts?
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<blockquote data-quote="Cataceous" data-source="post: 272589" data-attributes="member: 38109"><p>Perform a retest, ideally with both LC/MS and immunoassay tests. I would never trust a lone, unconfirmed LC/MS estradiol measurement. Although this testing methodology is capable of high accuracy, it is also complicated and fiddly and sensitive to human error. If the high estradiol is confirmed then I would have concerns about maintaining it long-term. My understanding is that you are taking 160 mg of testosterone cypionate per week. This about double what a sensible starting dose should be. Cutting back to 2 x 40 mg per week would make the absolute level of estradiol less unreasonable. You should also retest total testosterone and measure free testosterone with equilibrium dialysis. Throw in SHBG too so you can calculate free testosterone as a backup.</p><p></p><p>A total testosterone of 559 ng/dL seems low for the dose. It could be inaccurate, or it could be reflecting low SHBG or fast absorption. Further testing can help to sort this out. As it is, your estradiol-to-testosterone ratio is close to 2%, extremely high compared to the top of the normal range, which is around 0.6%.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 272589, member: 38109"] Perform a retest, ideally with both LC/MS and immunoassay tests. I would never trust a lone, unconfirmed LC/MS estradiol measurement. Although this testing methodology is capable of high accuracy, it is also complicated and fiddly and sensitive to human error. If the high estradiol is confirmed then I would have concerns about maintaining it long-term. My understanding is that you are taking 160 mg of testosterone cypionate per week. This about double what a sensible starting dose should be. Cutting back to 2 x 40 mg per week would make the absolute level of estradiol less unreasonable. You should also retest total testosterone and measure free testosterone with equilibrium dialysis. Throw in SHBG too so you can calculate free testosterone as a backup. A total testosterone of 559 ng/dL seems low for the dose. It could be inaccurate, or it could be reflecting low SHBG or fast absorption. Further testing can help to sort this out. As it is, your estradiol-to-testosterone ratio is close to 2%, extremely high compared to the top of the normal range, which is around 0.6%. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why is my Estradiol levels off the charts?
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