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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Why is HCG Important for Men on Testosterone Replacement Therapy?
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<blockquote data-quote="Nelson Vergel" data-source="post: 52172" data-attributes="member: 3"><p><span style="font-size: 15px"><span style="font-family: 'Georgia'"><span style="color: rgb(0, 0, 0)">Excellent observation. Evolution has made it possible to get every hormone axis to self-regulate depending on the amount of hormones in it. It was never intended to get hormones supplied from the outside world. The downregulation of the HPTA shuts down LH and FSH with obvious physiological disadvantages like low or no fertility. Replacing T via physiologic TRT normalizes only one hormone while leaving LH, FSH, pregnenolone and progesterone low or nil. DHT and E2 remain OK since they are downstream of T. If the body was just slowing down production of all those suppressed hormones to adjust them due to less need for them, why would the axis keep an important hormone like FSH shut down. That hormone ensures the survival of our species via sperm production. If this self-regulation was just part of homeostasis, then all organ functions would eventually be normalized (including testicular sperm production). We can speculate all day since we have hardly any data on the subject.</span></span></span></p><p></p><p><span style="font-size: 15px"><span style="font-family: 'Georgia'"><span style="color: #000000">There are references showing that LH itself may also have other roles since LH receptors are everywhere including the brain. Unfortunately, we do not have any scientific information of what happens to those receptor with long term LH shutdown. The same thing can be said about the shut down of pregnenolone and progesterone. Those two hormones have some limited references about their role in men's health:</span></span></span></p><p></p><p><span style="font-size: 15px"><span style="font-family: 'Georgia'"><span style="color: #000000"> </span><a href="https://www.excelmale.com/forum/showthread.php?7580-Pregnenolone-101-What-You-Need-to-Know-About-this-Precursor-Hormone" target="_blank">Pregnenolone 101: What You Need to Know About this Precursor Hormone</a> <span style="color: #000000">and </span></span></span></p><p></p><p><span style="font-size: 15px"><span style="font-family: 'Georgia'"><a href="https://www.excelmale.com/forum/showthread.php?6701-Progesterone" target="_blank">Progesterone in Men</a></span></span></p><p></p><p><span style="font-size: 15px"><span style="font-family: 'Georgia'"><span style="color: rgb(0, 0, 0)">This is an emerging field and we hope to see more studies that actually provide solid data on issues surrounding long term shut down of the HPTA and upstream steroid hormones caused by TRT.&</span></span></span></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 52172, member: 3"] [SIZE=15px][FONT=Georgia][COLOR=rgb(0, 0, 0)]Excellent observation. Evolution has made it possible to get every hormone axis to self-regulate depending on the amount of hormones in it. It was never intended to get hormones supplied from the outside world. The downregulation of the HPTA shuts down LH and FSH with obvious physiological disadvantages like low or no fertility. Replacing T via physiologic TRT normalizes only one hormone while leaving LH, FSH, pregnenolone and progesterone low or nil. DHT and E2 remain OK since they are downstream of T. If the body was just slowing down production of all those suppressed hormones to adjust them due to less need for them, why would the axis keep an important hormone like FSH shut down. That hormone ensures the survival of our species via sperm production. If this self-regulation was just part of homeostasis, then all organ functions would eventually be normalized (including testicular sperm production). We can speculate all day since we have hardly any data on the subject.[/COLOR][/FONT][/SIZE] [SIZE=15px][FONT=Georgia][COLOR=#000000]There are references showing that LH itself may also have other roles since LH receptors are everywhere including the brain. Unfortunately, we do not have any scientific information of what happens to those receptor with long term LH shutdown. The same thing can be said about the shut down of pregnenolone and progesterone. Those two hormones have some limited references about their role in men's health:[/COLOR][/FONT][/SIZE] [SIZE=15px][FONT=Georgia][COLOR=#000000] [/COLOR][URL="https://www.excelmale.com/forum/showthread.php?7580-Pregnenolone-101-What-You-Need-to-Know-About-this-Precursor-Hormone"]Pregnenolone 101: What You Need to Know About this Precursor Hormone[/URL] [COLOR=#000000]and [/COLOR][/FONT][/SIZE] [SIZE=15px][FONT=Georgia][URL="https://www.excelmale.com/forum/showthread.php?6701-Progesterone"]Progesterone in Men[/URL][/FONT][/SIZE] [SIZE=15px][FONT=Georgia][COLOR=rgb(0, 0, 0)]This is an emerging field and we hope to see more studies that actually provide solid data on issues surrounding long term shut down of the HPTA and upstream steroid hormones caused by TRT.&[/COLOR][/FONT][/SIZE] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Why is HCG Important for Men on Testosterone Replacement Therapy?
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