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Why does testosterone therapy decrease HDL cholesterol in some men?
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<blockquote data-quote="Nelson Vergel" data-source="post: 272939" data-attributes="member: 3"><p><a href="https://www.excelmale.com/forum/attachments/hdl_cholesterol_chart-jpg.1062/" target="_blank"><img src="https://www.excelmale.com/forum/data/attachments/0/738-e5cb893bc98ab9ac3bb6c927885e2673.jpg" class="bbImage" alt="" data-url="https://www.excelmale.com/forum/data/attachments/0/738-e5cb893bc98ab9ac3bb6c927885e2673.jpg" style="" /></a></p><p></p><p>James Semmens et al.</p><p>Metabolism</p><p>Volume 32, Issue 5, May 1983, Pages 428–432</p><p>[h1]<strong>Abstract</strong>[/h1]</p><p>The significance of sex hormone levels in determining variation in high-density lipoprotein cholesterol (HDL-C) concentrations was studied in healthy Seventh Day Adventists (vegetarians) and Mormons. These groups were selected to avoid the confounding effects of alcohol consumption and cigarette smoking on HDL-C concentrations. Multivariate analysis showed that testosterone has a strong negative association with HDL-C in men (t = 3.99, P &lt; 0.001) and women (t = 2.04, P &lt; 0.05) when controlled for other variables including the concentration of sex-hormone-binding globulin (SHBG). Sex-hormone-binding globulin showed an independent positive association with HDL-C in men (P &lt; 0.001). We postulate that the <strong>sex hormones affect HDL-C levels by regulating the activities of two important enzymes involved in the production and catabolism of HDL, namely, lipoprotein lipase and hepatic endothelial lipase.</strong> Other factors contributing independently to variation in HDL-C levels in this study were, in men, age and triglyceride, and in women, apoprotein-HDL, triglyceride, systolic <strong><a href="https://www.discountedlabs.com/blog/free-testosterone-6-ways-to-boost-it" target="_blank">blood pressure</a></strong>, heart rate, body mass index, and triceps skinfold thickness. Plasma estradiol concentrations were not significantly associated in either sex.</p><p></p><p><a href="https://www.excelmale.com/forum/threads/testosterone-or-anastrozole-decreased-my-hdl-what-can-i-do.10323/" target="_blank">Testosterone (or Anastrozole?) Decreased my HDL: What Can I Do?</a></p><p></p><p><a href="https://www.excelmale.com/forum/threads/how-to-increase-good-cholesterol-hdl.2341/" target="_blank">How to Increase Good Cholesterol (HDL)</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 272939, member: 3"] [url=https://www.excelmale.com/forum/attachments/hdl_cholesterol_chart-jpg.1062/][img]https://www.excelmale.com/forum/data/attachments/0/738-e5cb893bc98ab9ac3bb6c927885e2673.jpg[/img][/url] James Semmens et al. Metabolism Volume 32, Issue 5, May 1983, Pages 428–432 [h1][b]Abstract[/b][/h1] The significance of sex hormone levels in determining variation in high-density lipoprotein cholesterol (HDL-C) concentrations was studied in healthy Seventh Day Adventists (vegetarians) and Mormons. These groups were selected to avoid the confounding effects of alcohol consumption and cigarette smoking on HDL-C concentrations. Multivariate analysis showed that testosterone has a strong negative association with HDL-C in men (t = 3.99, P < 0.001) and women (t = 2.04, P < 0.05) when controlled for other variables including the concentration of sex-hormone-binding globulin (SHBG). Sex-hormone-binding globulin showed an independent positive association with HDL-C in men (P < 0.001). We postulate that the [b]sex hormones affect HDL-C levels by regulating the activities of two important enzymes involved in the production and catabolism of HDL, namely, lipoprotein lipase and hepatic endothelial lipase.[/b] Other factors contributing independently to variation in HDL-C levels in this study were, in men, age and triglyceride, and in women, apoprotein-HDL, triglyceride, systolic [b][url=https://www.discountedlabs.com/blog/free-testosterone-6-ways-to-boost-it]blood pressure[/url][/b], heart rate, body mass index, and triceps skinfold thickness. Plasma estradiol concentrations were not significantly associated in either sex. [url=https://www.excelmale.com/forum/threads/testosterone-or-anastrozole-decreased-my-hdl-what-can-i-do.10323/]Testosterone (or Anastrozole?) Decreased my HDL: What Can I Do?[/url] [url=https://www.excelmale.com/forum/threads/how-to-increase-good-cholesterol-hdl.2341/]How to Increase Good Cholesterol (HDL)[/url] [/QUOTE]
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Why does testosterone therapy decrease HDL cholesterol in some men?
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